Abstract
The perineurioma is an infrequently encountered benign peripheral nerve sheath tumor composed of a clonal proliferation of perineurial cells. Rare cases of perineurioma have been reported in the oral cavity. An extraneural sclerosing perineurioma arising in the buccal mucosa of a 17-year-old male is presented. Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged around vascular channels. The tumor cells reveal positive immunostaining for epithelial membrane antigen (EMA), collagen type IV and vimentin, and negative immunostaining for S-100 protein, consistent with a perineurial origin. To the best of our knowledge, this case represents the first report of an extraneural sclerosing perineurioma involving the oral cavity.
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Acknowledgments
We acknowledge Dr. Christopher D.M. Fletcher, professor of pathology and director of surgical pathology, Brigham and Women’s Hospital, Boston, MA for his assistance in the histopathologic evaluation of this case. Additionally, we thank Ms. Anita Knighton and the laboratory staff in the Department of Pathology and Laboratory Medicine at Harvard Vanguard Medical Associates for technical expertise and Dr. George Gallagher and Dr. Devaki Sundararajan, Boston University School of Dental Medicine, for assistance with photomicroscopy.
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Noonan, V.L., Greene, D.J., Brodsky, G. et al. Extraneural Sclerosing Perineurioma of the Buccal Mucosa: A Case Report and Clinicopathologic Review. Head and Neck Pathol 4, 169–173 (2010). https://doi.org/10.1007/s12105-010-0175-5
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DOI: https://doi.org/10.1007/s12105-010-0175-5