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Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

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Abstract

Objective

The current study was conducted to compare the diagnostic accuracy between 18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT), and conventional imaging (CI) for the staging and re-staging of patients with rhabdomyosarcomas.

Methods

Thirty-five patients who underwent FDG PET/CT prior to treatment were evaluated retrospectively. CI methods consisted of 99mTc-hydroxymethylene diphosphonate bone scintigraphy, chest radiograph, whole body CT, and magnetic resonance imaging of the primary site. The images were reviewed and two boardcertified radiologists reached a diagnostic consensus. Tumor stage was confirmed by histological examination and/or follow-up examinations.

Results

Interpretation on the basis of FDG PET/CT, and CI, diagnostic accuracies of the T and N stages were similar. Using FDG PET/CT, the M stage was correctly assigned in 31 patients (89%), whereas the accuracy of CI in M stage was 63%. TNM stage was correctly assessed with FDG PET/CT in 30 of 35 patients (86%) and with CI in 19 of 35 patients (54%). The overall TNM staging and M staging accuracies of FDG PET/CT were significantly higher than that of CI (P < 0.01).

Conclusions

FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.

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Authors and Affiliations

  1. Department of Radiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan

    Ukihide Tateishi & Tomio Inoue

  2. Division of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan

    Ako Hosono & Atsushi Makimoto

  3. Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Yuki Nakamoto & Tsuyoshi Suga

  4. Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Tomohiro Kaneta & Hiroshi Fukuda

  5. PET Center, Dokkyo Medical University, Tochigi, Japan

    Koji Murakami

  6. Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

    Takashi Terauchi & Edmund E. Kim

Authors
  1. Ukihide Tateishi
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  2. Ako Hosono
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  3. Atsushi Makimoto
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  4. Yuki Nakamoto
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  5. Tomohiro Kaneta
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  6. Hiroshi Fukuda
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  7. Koji Murakami
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  8. Takashi Terauchi
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  9. Tsuyoshi Suga
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  10. Tomio Inoue
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  11. Edmund E. Kim
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Corresponding author

Correspondence to Ukihide Tateishi.

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Tateishi, U., Hosono, A., Makimoto, A. et al. Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma. Ann Nucl Med 23, 155–161 (2009). https://doi.org/10.1007/s12149-008-0219-z

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  • DOI: https://doi.org/10.1007/s12149-008-0219-z

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