Skip to main content

Advertisement

SpringerLink
Log in

Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography

  • Original Article
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

To evaluate the role of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in intravascular large B-cell lymphoma (IVLBCL), we retrospectively analyzed four consecutive IVLBCL patients receiving FDG-PET before treatment between May 2006 and November 2007. Patients were two men and two women (median age 62 years, range 54–76 years). All patients received bone marrow biopsies and random skin biopsies and two of the four patients underwent renal biopsy for diagnosis. Accuracy of FDG-PET for the detection of organ involvements was analyzed by comparing results of pathological findings. Concordant results with respect to bone marrow involvement were accurately obtained for two patients. Skin and renal involvements were undetectable by FDG-PET regardless of positive pathological findings. One patient with a false-negative FDG-PET result showed fewer lymphoma cells in the bone marrow specimen than patients with concordant FDG-PET results. These results suggest false-negative results for some types of organ involvement. Careful interpretation of the results of FDG-PET in IVLBCL is thus required.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol. 2007;25:571–8.

    Article  PubMed  Google Scholar 

  2. Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, et al. Revised response criteria for malignant lymphoma. J Clin Oncol. 2007;25:579–86.

    Article  PubMed  Google Scholar 

  3. Gatter KC, Warnke RA. Intravascular large B-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization: pathology and genetics of tumors of haematopoietic and lymphoid tissues. Lyon: IARC;2001. pp. 177–8.

    Google Scholar 

  4. Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, et al. Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol. 2007;25:3168–73.

    Article  PubMed  Google Scholar 

  5. Wirth A, Seymour JF, Hicks RJ, Ware R, Fisher R, Prince M, et al. Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin’s disease and non-Hodgkin’s lymphoma. Am J Med. 2002;112:262–8.

    Article  PubMed  Google Scholar 

  6. Hernandez-Maraver D, Hernandez-Navarro F, Gomez-Leon N, Coya J, Rodriguez-Vigil B, Madero R, et al. Positron emission tomography/computed tomography: diagnostic accuracy in lymphoma. Br J Haematol. 2006;135:293–302.

    Article  PubMed  Google Scholar 

  7. Elstrom R, Guan L, Baker G, Nakhoda K, Vergilio JA, Zhuang H, et al. Utility of FDG-PET scanning in lymphoma by WHO classification. Blood. 2003;101:3875–6.

    Article  CAS  PubMed  Google Scholar 

  8. Odawara J, Asada N, Aoki T, Yamakura M, Takeuchi M, Ohuchi T, et al. 18F-Fluorodeoxyglucose positron emission tomography for evaluation of intravascular large B-cell lymphoma. Br J Haematol. 2007;136:684.

    Article  PubMed  Google Scholar 

  9. Lannoo L, Smets S, Steenkiste E, Delforge M, Moerman P, Stroobants S, et al. Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET. Acta Clin Belg. 2007;62:187–90.

    Article  CAS  PubMed  Google Scholar 

  10. Hoshino A, Kawada E, Ukita T, Itoh K, Sakamoto H, Fujita K, et al. Usefulness of FDG-PET to diagnose intravascular lymphomatosis presenting as fever of unknown origin. Am J Hematol. 2004;76:236–9.

    Article  CAS  PubMed  Google Scholar 

  11. Hofman MS, Fields P, Yung L, Mikhaeel NG, Ireland R, Nunan T. Meningeal recurrence of intravascular large B-cell lymphoma: early diagnosis with PET-CT. Br J Haematol. 2007;137:386.

    Article  PubMed  Google Scholar 

  12. Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru J, et al. Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood. 2007;109:478–85.

    Article  CAS  PubMed  Google Scholar 

  13. Gill S, Melosky B, Haley L, ChanYan C. Use of random skin biopsy to diagnose intravascular lymphoma presenting as fever of unknown origin. Am J Med. 2003;114:56–8.

    Article  PubMed  Google Scholar 

  14. Asada N, Odawara J, Kimura S, Aoki T, Kamakura M, Takeuchi M, et al. Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc. 2007;82:1525–7.

    Article  PubMed  Google Scholar 

  15. Seam P, Juweid ME, Cheson BD. The role of FDG-PET scans in patients with lymphoma. Blood. 2007;110:3507–16.

    Article  CAS  PubMed  Google Scholar 

  16. Rosenbaum SJ, Lind T, Antoch G, Bockisch A. False-positive FDG PET uptake–the role of PET/CT. Eur Radiol. 2006;16:1054–65.

    Article  PubMed  Google Scholar 

  17. Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, et al. A retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapies as reported by the IVL study group in Japan. J Clin Oncol. 2008 (in press)

  18. Wu SJ, Chou WC, Ko BS, Tien HF. Severe pulmonary complications after initial treatment with Rituximab for the Asian-variant of intravascular lymphoma. Haematologica. 2007;92:141–2.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan

    Kazuyuki Shimada, Hiroshi Kosugi, Yoshitsugu Koyama, Nobuaki Suzuki & Masaaki Yuge

  2. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Kazuyuki Shimada, Hiroto Narimatsu, Tomoki Naoe & Tomohiro Kinoshita

  3. Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan

    Satoko Shimada & Shigeo Nakamura

  4. Department of Radiology, Kizawa Memorial Hospital, Minokamo, Japan

    Hironori Nishibori

  5. Department of Pathology, Ogaki Municipal Hospital, Ogaki, Japan

    Yosuke Iwata

Authors
  1. Kazuyuki Shimada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Kosugi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Satoko Shimada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hiroto Narimatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshitsugu Koyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nobuaki Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masaaki Yuge
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hironori Nishibori
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yosuke Iwata
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shigeo Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Tomoki Naoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Tomohiro Kinoshita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kazuyuki Shimada.

About this article

Cite this article

Shimada, K., Kosugi, H., Shimada, S. et al. Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography. Int J Hematol 88, 149–153 (2008). https://doi.org/10.1007/s12185-008-0102-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12185-008-0102-7

Keywords

Search

Navigation