Skip to main content

Advertisement

Log in

Mammary ductoscopy: current issues and perspectives

  • Review Article
  • Published:
Breast Cancer Aims and scope Submit manuscript

Abstract

Until recently, the mammary duct had not been directly observed in vivo. Starting with the success of Teboul et al., studies of mammary ductoscopy (MD) for nipple discharge have been performed in Japan and other East Asian countries. Ductal lavage screening trials for breast cancer started in the 2000s. Concurrently, the number of English-language articles about MD increased. Sixty-nine English-language and 74 Japanese-language papers published in the last 19 years were reviewed. Important reports and studies were analyzed. MD has undergone significant technological development, and studies of MD have taken place in many countries. As a result, endoscopic images of the mammary duct have developed, and the endoscopic diagnosis for nipple discharge has become possible. MD-guided biopsy and surgery have been studied. Findings of MD are useful for diagnosing intraductal lesions with nipple discharge. As a result, MD has reduced the number and extent of microdochectomies. MD is also helpful in guiding breast-conserving surgery. Many pioneers have tried direct biopsy or interventions under MD, but further developments are necessary for its practical use.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

MD:

Mammary ductoscopy

References

  1. Teboul M. Echo-histological “acino-ductal analysis”. Preliminary results. Ultrasound Med Biol. 1988;14(1):89–95.

    Article  PubMed  Google Scholar 

  2. Makita M, Sakamoto G, Namba K, et al. Mammary ductoscopy. Jpn J Breast Cancer. 1989;4(4):571–5.

    Google Scholar 

  3. Berna JD, Garcia-Medina V, Kuni CC. Ductoscopy: a new technique for ductal exploration. Eur J Radiol. 1991;12:127–9.

    Article  PubMed  CAS  Google Scholar 

  4. Okazaki A, Okazaki M, Asaishi K, et al. Fiberoptic ductoscopy of the breast: a new diagnostic procedure for nipple discharge. Jpn J Clin Oncol. 1991;21(3):188–93.

    PubMed  CAS  Google Scholar 

  5. Japanese Association of Mammary Ductoscopy. Endoscopic classification of intraductal lesions. In: Proceedings of 6th annual meeting of Japanese Association of Mammary Ductoscopy; 2001.

  6. Makita M, Akiyama F, Gomi N, et al. Endoscopic classification of intraductal lesions and histological diagnosis. Breast Cancer. 2002;9(3):220–5.

    Article  PubMed  Google Scholar 

  7. Matsunaga T, Ohta D, Misaka T, et al. Mammary ductoscopy for diagnosis and treatment of intraductal lesions of the breast. Breast Cancer. 2001;18(3):213–21.

    Article  Google Scholar 

  8. Okazaki A, Hirata K, Okazaki K, et al. Nipple discharge disorders: current diagnostic management and the role of fiber-ductoscopy. Eur Radiol. 1999;9:583–90.

    Article  PubMed  CAS  Google Scholar 

  9. Shen KW, Wu J, Lu JS, et al. Fiberoptic ductoscopy for patients with nipple discharge. Cancer. 2000;89(7):1512–9.

    Article  PubMed  CAS  Google Scholar 

  10. Dooley WC, Ljung B-M, Veronesi U, et al. Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. J Natl Cancer Inst. 2001;93(21):1624–32.

    Article  PubMed  CAS  Google Scholar 

  11. Love SM, Barsky SH. Breast-duct endoscopy to study stages of cancerous breast disease. Lancet. 1996;348:997–9.

    Article  PubMed  CAS  Google Scholar 

  12. Sauter ER, Ehya H, Schlatter L, et al. Ductoscopic cytology to detect breast cancer. Cancer J. 2004;10(1):33–41.

    Article  PubMed  Google Scholar 

  13. Badve S, Wiley E, Rodriguez N, et al. Assessment of utility of ductal lavage and ductoscopy in breast cancer-A retrospective analysis of mastectomy specimens. Mod Pathol. 2003;16(3):206–9.

    Article  PubMed  Google Scholar 

  14. Beechey-Newman N, Kulkarni D, et al. Breast duct microendoscopy in nipple discharge: microbrush improves cytology. Surg Endosc. 2005;19(12):1648–51.

    Article  PubMed  CAS  Google Scholar 

  15. Namba k, Sakamoto G, Akiyama F, et al. Intraductal biopsy of the breast (I.D.B.B) for intraductal lesions––a case of breast cancer diagnosed by I.D.B.B. Jpn J Breast Cancer. 1989;4(2):253–8.

    Google Scholar 

  16. Makita M, Sakamoto G, Akiyama F, et al. Duct endoscopy and endoscopic biopsy in the evaluation of nipple discharge. Breast Cancer Res Treat. 1991;18(3):179–87.

    Article  PubMed  CAS  Google Scholar 

  17. Matsunaga T, Kawakami Y, Namba K, et al. Intraductal biopsy for diagnosis and treatment of intraductal lesions of the breast. Cancer. 2004;101(10):2164–9.

    Article  PubMed  Google Scholar 

  18. Sharma R, Dietz J, Wright H, et al. Comparative analysis of minimally invasive microductectomy versus major duct excision in patients with pathologic nipple discharge. Surgery. 2005;138(4):591–7.

    Article  PubMed  Google Scholar 

  19. Dietz JR, Crowe JP, Grundfest S, et al. Directed duct excision by using mammary ductoscopy in patients with pathologic nipple discharge. Surgery. 2002;132(4):582–8.

    Article  PubMed  Google Scholar 

  20. Moncrief RM, Nayar R, Diez LK, et al. A comparison of ductoscopy-guided and conventional surgical excision in women with spontaneous nipple discharge. Ann Surg. 2005;24(4):575–81.

    Article  Google Scholar 

  21. Escobar PF, Baynes D, Crowe JP. Ductoscopy-assisted microdochectomy. Int J Fertil. 2004;49(5):222–4.

    Google Scholar 

  22. Dooley WC. Routine operative breast endoscopy for bloody nipple discharge. Ann Surg Oncol. 2002;9(9):920–3.

    Article  PubMed  Google Scholar 

  23. Kim JA, Crowe JP, Woletz J, et al. Prospective study of intraoperative mammary ductoscopy in patients undergoing partial mastectomy for breast cancer. Am J Surg. 2004;188:411–4.

    Article  PubMed  Google Scholar 

  24. Fukuda Y, Kawano Y, Tanikawa Y, Oba M, Koyama M, Takagi H, et al. In vivo imaging of the dendritic arbors of layer V pyramidal cells in the cerebral cortex using a laser scanning microscope with a stick-type objective lens. Neurosci Lett. 2006;400(1–2):53–7.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ken Uchida.

About this article

Cite this article

Uchida, K., Fukushima, H., Toriumi, Y. et al. Mammary ductoscopy: current issues and perspectives. Breast Cancer 16, 93–96 (2009). https://doi.org/10.1007/s12282-008-0083-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12282-008-0083-7

Keywords

Navigation