Abstract
Until recently, the mammary duct had not been directly observed in vivo. Starting with the success of Teboul et al., studies of mammary ductoscopy (MD) for nipple discharge have been performed in Japan and other East Asian countries. Ductal lavage screening trials for breast cancer started in the 2000s. Concurrently, the number of English-language articles about MD increased. Sixty-nine English-language and 74 Japanese-language papers published in the last 19 years were reviewed. Important reports and studies were analyzed. MD has undergone significant technological development, and studies of MD have taken place in many countries. As a result, endoscopic images of the mammary duct have developed, and the endoscopic diagnosis for nipple discharge has become possible. MD-guided biopsy and surgery have been studied. Findings of MD are useful for diagnosing intraductal lesions with nipple discharge. As a result, MD has reduced the number and extent of microdochectomies. MD is also helpful in guiding breast-conserving surgery. Many pioneers have tried direct biopsy or interventions under MD, but further developments are necessary for its practical use.
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Abbreviations
- MD:
-
Mammary ductoscopy
References
Teboul M. Echo-histological “acino-ductal analysis”. Preliminary results. Ultrasound Med Biol. 1988;14(1):89–95.
Makita M, Sakamoto G, Namba K, et al. Mammary ductoscopy. Jpn J Breast Cancer. 1989;4(4):571–5.
Berna JD, Garcia-Medina V, Kuni CC. Ductoscopy: a new technique for ductal exploration. Eur J Radiol. 1991;12:127–9.
Okazaki A, Okazaki M, Asaishi K, et al. Fiberoptic ductoscopy of the breast: a new diagnostic procedure for nipple discharge. Jpn J Clin Oncol. 1991;21(3):188–93.
Japanese Association of Mammary Ductoscopy. Endoscopic classification of intraductal lesions. In: Proceedings of 6th annual meeting of Japanese Association of Mammary Ductoscopy; 2001.
Makita M, Akiyama F, Gomi N, et al. Endoscopic classification of intraductal lesions and histological diagnosis. Breast Cancer. 2002;9(3):220–5.
Matsunaga T, Ohta D, Misaka T, et al. Mammary ductoscopy for diagnosis and treatment of intraductal lesions of the breast. Breast Cancer. 2001;18(3):213–21.
Okazaki A, Hirata K, Okazaki K, et al. Nipple discharge disorders: current diagnostic management and the role of fiber-ductoscopy. Eur Radiol. 1999;9:583–90.
Shen KW, Wu J, Lu JS, et al. Fiberoptic ductoscopy for patients with nipple discharge. Cancer. 2000;89(7):1512–9.
Dooley WC, Ljung B-M, Veronesi U, et al. Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. J Natl Cancer Inst. 2001;93(21):1624–32.
Love SM, Barsky SH. Breast-duct endoscopy to study stages of cancerous breast disease. Lancet. 1996;348:997–9.
Sauter ER, Ehya H, Schlatter L, et al. Ductoscopic cytology to detect breast cancer. Cancer J. 2004;10(1):33–41.
Badve S, Wiley E, Rodriguez N, et al. Assessment of utility of ductal lavage and ductoscopy in breast cancer-A retrospective analysis of mastectomy specimens. Mod Pathol. 2003;16(3):206–9.
Beechey-Newman N, Kulkarni D, et al. Breast duct microendoscopy in nipple discharge: microbrush improves cytology. Surg Endosc. 2005;19(12):1648–51.
Namba k, Sakamoto G, Akiyama F, et al. Intraductal biopsy of the breast (I.D.B.B) for intraductal lesions––a case of breast cancer diagnosed by I.D.B.B. Jpn J Breast Cancer. 1989;4(2):253–8.
Makita M, Sakamoto G, Akiyama F, et al. Duct endoscopy and endoscopic biopsy in the evaluation of nipple discharge. Breast Cancer Res Treat. 1991;18(3):179–87.
Matsunaga T, Kawakami Y, Namba K, et al. Intraductal biopsy for diagnosis and treatment of intraductal lesions of the breast. Cancer. 2004;101(10):2164–9.
Sharma R, Dietz J, Wright H, et al. Comparative analysis of minimally invasive microductectomy versus major duct excision in patients with pathologic nipple discharge. Surgery. 2005;138(4):591–7.
Dietz JR, Crowe JP, Grundfest S, et al. Directed duct excision by using mammary ductoscopy in patients with pathologic nipple discharge. Surgery. 2002;132(4):582–8.
Moncrief RM, Nayar R, Diez LK, et al. A comparison of ductoscopy-guided and conventional surgical excision in women with spontaneous nipple discharge. Ann Surg. 2005;24(4):575–81.
Escobar PF, Baynes D, Crowe JP. Ductoscopy-assisted microdochectomy. Int J Fertil. 2004;49(5):222–4.
Dooley WC. Routine operative breast endoscopy for bloody nipple discharge. Ann Surg Oncol. 2002;9(9):920–3.
Kim JA, Crowe JP, Woletz J, et al. Prospective study of intraoperative mammary ductoscopy in patients undergoing partial mastectomy for breast cancer. Am J Surg. 2004;188:411–4.
Fukuda Y, Kawano Y, Tanikawa Y, Oba M, Koyama M, Takagi H, et al. In vivo imaging of the dendritic arbors of layer V pyramidal cells in the cerebral cortex using a laser scanning microscope with a stick-type objective lens. Neurosci Lett. 2006;400(1–2):53–7.
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Uchida, K., Fukushima, H., Toriumi, Y. et al. Mammary ductoscopy: current issues and perspectives. Breast Cancer 16, 93–96 (2009). https://doi.org/10.1007/s12282-008-0083-7
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DOI: https://doi.org/10.1007/s12282-008-0083-7