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Human dermal matrix scaffold augmentation for large and massive rotator cuff repairs: preliminary clinical and MRI results at 1-year follow-up

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Abstract

The high incidence of recurrent tendon tears after repair of massive cuff lesions is prompting the research of materials aimed at mechanically or biologically reinforcing the tendon. Among the materials studied upto now, the extracellular matrix (ECM) scaffolds of human origin have proved to be the safest and most efficient, but the current laws about grafts and transplants preclude their use in Europe. In order to overcome this condition in 2006, we started a project regarding the production of an ECM scaffold of human origin which could be implanted in Europe too. In 2009, the clinical study began with the implantation of dermal matrix scaffolds in 7 middle-aged patients affected with large/massive cuff lesions and tendon degeneration. Out of 5 cases, followed for at least 1 year in which the scaffold was employed as an augmentation device, there were 3 patients with complete healing, 1 partial re-tear, and 1 total recurrence. The absence of adverse inflammatory or septic complications allows to continue this line of research with a prospective controlled study in order to define the real advantages and correct indications offered by scaffold application.

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Conflict of interest

The authors declare that they have no conflict of interest related to the publication of this manuscript. The authors FM and BE are among the inventors of the patent on the decellularization method that was applied on the human dermis.

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Authors and Affiliations

  1. Shoulder and Elbow Unit, Rizzoli Orthopaedic Institute, via Pupilli 1, Bologna, Italy

    Roberto Rotini, Alessandro Marinelli, Enrico Guerra & Graziano Bettelli

  2. IRCCS Clinical Institute Humanitas, via Manzoni 56, 20089, Milan, Rozzano, Italy

    Alessandro Castagna

  3. Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy

    Milena Fini

  4. Burn Intensive Care Unit and “Regione Emilia Romagna” Skin Bank, Bufalini Hospital, viale Ghirotti 286, 47023, Cesena, Italy

    Elena Bondioli

  5. Department of Radiology, Rizzoli Orthopaedic Institute, via Pupilli 1, 40136, Bologna, Italy

    Maurizio Busacca

Authors
  1. Roberto Rotini
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  2. Alessandro Marinelli
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  3. Enrico Guerra
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  4. Graziano Bettelli
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  5. Alessandro Castagna
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  6. Milena Fini
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  7. Elena Bondioli
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  8. Maurizio Busacca
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Correspondence to Roberto Rotini.

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Rotini, R., Marinelli, A., Guerra, E. et al. Human dermal matrix scaffold augmentation for large and massive rotator cuff repairs: preliminary clinical and MRI results at 1-year follow-up. Musculoskelet Surg 95 (Suppl 1), 13–23 (2011). https://doi.org/10.1007/s12306-011-0141-8

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  • DOI: https://doi.org/10.1007/s12306-011-0141-8

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