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High Width Variability during Spiral Drawing: Further Evidence of Cerebellar Dysfunction in Essential Tremor

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Abstract

Essential tremor (ET) is among the most prevalent neurological diseases, yet the location of the primary disease substrate continues to be a matter of debate. The presence of intention tremor and mild gait ataxia suggests an underlying abnormality of the cerebellum and/or cerebellar pathways. Uncovering additional signs of cerebellar dysfunction would further substantiate the proposition that ET is a disease of the cerebellar system. We evaluated 145 ET cases and 34 normal controls clinically and by computerized spiral analysis. Spiral analysis is a program that objectively characterizes kinematic and physiologic features of hand-drawn spirals using specific calculated spiral indices that correlate with spiral shape and motor execution. We used the spiral width variability index (SWVI), a measure of loop-to-loop spiral width variation with the influence of tremor removed, as a metric of drawing ataxia. The SWVI was higher in cases than controls (0.91 ± 1.94, median = 0.46 vs. 0.40 ± 0.29, median = 0.30, p < 0.001). Cases with higher SWVI also had greater intention tremor during the finger–nose–finger maneuver, r = 0.27, p = 0.001), and cases with intention tremor of the head had the highest SWVI (1.57 ± 3.44, median = 0.51, p < 0.001). There was a modest association between SWVI and number of missteps during tandem gait (r = 0.16, p = 0.06). The primary anatomical substrate for ET continues to be a matter of speculation, yet these and other clinical data lend support to the notion that there is an underlying abnormality of the cerebellum and/or its pathways.

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Acknowledgments

R01 NS042859 from the National Institutes of Health (Bethesda, MD, USA; EDL) and support from the Parkinson Disease Foundation (New York, NY, USA; CWH, SLP).

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Correspondence to Elan D. Louis.

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Louis, E.D., Gillman, A., Boschung, S. et al. High Width Variability during Spiral Drawing: Further Evidence of Cerebellar Dysfunction in Essential Tremor. Cerebellum 11, 872–879 (2012). https://doi.org/10.1007/s12311-011-0352-4

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