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Developmental comorbidity in attention-deficit/hyperactivity disorder

  • Review Article
  • Published:
ADHD Attention Deficit and Hyperactivity Disorders

Abstract

With the present review, we intend to highlight the importance of considering the age- and development-dependent occurrence of comorbidity in ADHD and to outline distinct trajectories of symptom progression with possible impact on course and outcome of ADHD. The review will focus on introducing the concepts of “developmental epidemiology” and “developmental comorbidity”. Psychiatric and non-psychiatric age-dependent comorbidity can be seen in the majority of children, adolescents and adults with ADHD, resulting in a severe impairment of everyday life with considerable functional and psychosocial problems. Concerning the temporal order of occurrence, psychiatric conditions may be present before the appearance of first definite ADHD symptoms (“pre-comorbidity”, such as temperament factors, sleep disturbance, autism spectrum disorders and atopic eczema). They may coincide with the time when ADHD symptoms reach a clinically significant level (“simultaneous comorbidity”: enuresis, encopresis, developmental dyslexia). The majority of comorbidity, however, appears after the onset of ADHD in the course of disease (“post-comorbidity”: tic disorder, depression and suicidality, anxiety disorders, obsessive compulsive disorder, bipolar disorder, conduct and substance use disorders, obesity and personality disorders). The aetio-pathophysiology of ADHD and its comorbid disorders and also the nature of comorbidity itself being highly heterogeneous, we additionally discuss possible models of comorbidity. In the future, longitudinal data on distinct patterns of symptom and comorbidity progression would help to refine disease classification systems, strengthen the power of future genetic studies and finally allow for more specific treatment strategies.

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References

  • Acosta MT, Castellanos FX, Bolton KL, Balog JZ, Eagen P, Nee L, Jones J, Palacio L, Sarampote C, Russell HF, Berg K, Arcos-Burgos M, Muenke M (2008) Latent class subtyping of attention-deficit/hyperactivity disorder and comorbid conditions. J Am Acad Child Adolesc Psychiatry 47:797–807

    Article  PubMed  Google Scholar 

  • Adler LA, Liebowitz M, Kronenberger W, Qiao M, Rubin R, Hollandbeck M, Deldar A, Schuh K, Durell T (2009) Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder and comorbid social anxiety disorder. Depress Anxiety 26:212–221

    Article  CAS  PubMed  Google Scholar 

  • Agranat-Meged A, Ghanadri Y, Eisenberg I, Ben Neriah Z, Kieselstein-Gross E, Mitrani-Rosenbaum S (2008) Attention deficit hyperactivity disorder in obese melanocortin-4-receptor (MC4R) deficient subjects: a newly described expression of MC4R deficiency. Am J Med Genet B Neuropsychiatr Genet 147B:1547–1553

    Article  CAS  PubMed  Google Scholar 

  • Altfas JR (2002) Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry 2:9

    Article  PubMed  Google Scholar 

  • Angold A, Costello EJ (1993) Depressive comorbidity in children and adolescents: empirical, theoretical and methodological issues. Am J Psychiatry 150:1779–1791

    CAS  PubMed  Google Scholar 

  • Angold A, Costello EJ, Erkanli A (1999) Comorbidity. J Child Psychol Psychiatry 40:57–87

    Article  CAS  PubMed  Google Scholar 

  • Anney RJL, Lasky-Su J, O’Dúshláine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vásquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M (2008) Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. Am J Med Genet B Neuropsychiatr Genet 147B:1369–1378

    Article  CAS  PubMed  Google Scholar 

  • Arnold PD, Ickowicz A, Chen S, Schachar R (2005) Attention-deficit hyperactivity disorder with and without obsessive-compulsive behaviours: clinical characteristics, cognitive assessment, and risk factors. Can J Psychiatry 50:59–66

    PubMed  Google Scholar 

  • August GJ (1990) Comorbidity of ADHD and reading disability among clinic-referred children. J Abnorm Child Psychol 18:29–45

    Article  CAS  PubMed  Google Scholar 

  • Babinski LM, Hartsough CS, Lambert NM (1999) Childhood conduct problems, hyperactivity-impulsivity and inattention as predictors of adult criminal activity. J Child Psychol Psychiatry 40:347–355

    Article  CAS  PubMed  Google Scholar 

  • Baeyens D, Roeyers H, Hoebeke P, Verté S, Van Hoecke E, Walle JV (2004) Attention deficit/hyperactivity disorder in children with nocturnal enuresis. J Urol 171:2576–2579

    Article  PubMed  Google Scholar 

  • Baeyens D, Roeyers H, D’Haese L, Pieters F, Hoebeke P, Vande Walle J (2006) The prevalence of ADHD in children with enuresis: comparison between a tertiary and non-tertiary care sample. Acta Paediatr 95:347–352

    Article  PubMed  Google Scholar 

  • Baeyens D, Roeyers H, Van Erdeghem S, Hoebeke P, Vande Walle J (2007) The prevalence of attention deficit-hyperactivity disorder in children with nonmonosymptomatic nocturnal enuresis: a 4-year followup study. J Urol 178:2616–2620

    Article  PubMed  Google Scholar 

  • Bailey JN, Ornitz EM, Gehricke JG, Gabikian P, Russell AT, Smalley SL (1999) Transmission of primary nocturnal enuresis and attention deficit hyperactivity disorder. Acta Paediatr 88:1364–1368

    Article  CAS  PubMed  Google Scholar 

  • Banaschewski T, Hollis C, Oosterlaan J, Roeyers H, Rubia K, Willcutt E, Taylor E (2005) Towards an understanding of unique and shared pathways in the psychopathophysiology of ADHD. Dev Sci 8:132–140

    Article  PubMed  Google Scholar 

  • Banaschewski T, Neale BM, Rothenberger A, Roessner V (2007) Comorbidity of tic disorders & ADHD: conceptual and methodological considerations. Eur Child Adolesc Psychiatry 1:5–14 Review

    Article  Google Scholar 

  • Banerjee TD, Middleton F, Faraone SV (2007) Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 96:1269–1274

    Article  PubMed  Google Scholar 

  • Barkley RA (2006) Attention-deficit hyperactivity disorder: a handbook for diagnosis and treatment. Guilford Press, New York

    Google Scholar 

  • Barkley RA, Fischer M, Edelbrock CS, Smallish L (1990) The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry 29:546–557

    Article  CAS  PubMed  Google Scholar 

  • Bernardi S, Cortese S, Solanto M, Hollander E, Pallanti S (2010) Bipolar disorder, comorbid attention deficit hyperactivity disorder. A distinct clinical phenotype? Clinical characteristics and temperamental traits. World J Biol Psychiatry 11:656–666

    Article  PubMed  Google Scholar 

  • Biederman J (1990) Attention deficit hyperactivity disorder. Annu Clin Psychiatry 3:9–22

    Article  Google Scholar 

  • Biederman J, Faraone SV (2005) Attention-deficit hyperactivity disorder. Lancet 366:237–248

    Article  PubMed  Google Scholar 

  • Biederman J, Newcorn J, Sprich S (1991a) Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry 148:564–577

    CAS  PubMed  Google Scholar 

  • Biederman J, Faraone SV, Keenan K, Steingard R, Tsuang MT (1991b) Familial association between attention deficit disorder and anxiety disorders. Am J Psychiatry 148:251–256

    CAS  PubMed  Google Scholar 

  • Biederman J, Faraone SV, Keenan K, Benjamin J, Krifcher B, Moore C et al (1992) Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder: patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples. Arch Gen Psychiatry 49:728–738

    CAS  PubMed  Google Scholar 

  • Biederman J, Wilens T, Mick E, Milberger S, Spencer TJ, Faraone SV (1995a) Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry 152:1652–1658

    CAS  PubMed  Google Scholar 

  • Biederman J, Rosenbaum JF, Chaloff J, Kagan J (1995b) Behavioural inhibition as a risk factor for anxiety disorders. In: March JS (ed) Anxiety disorders in children and adolescents. The Guilford Press, New York, pp 61–81

    Google Scholar 

  • Biederman J, Wozniak J, Kiely K, Ablon S, Faraone S, Mick E, Mundy E, Kraus I (1995c) CBCL clinical scales discriminate prepubertal children with structured interview-derived diagnosis of mania from those with ADHD. J Am Acad Child Adolesc Psychiatry 34:464–471

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Faraone S, Mick E, Lelon E (1995d) Psychiatric comorbidity among referred juveniles with major depression: fact or artifact? J Am Acad Child Adolesc Psychiatry 34:579–590

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Faraone SV, Milberger S, Curtis S, Chen L, Marrs A, Ouellette C, Moore P, Spencer T (1996) Predictors of persistence and remission of ADHD: results from a four year prospective follow-up study of ADHD children. J Am Acad Child Adolesc Psychiatry 35:343–351

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Mick E, Faraone SV (1998) Depression in attention deficit hyperactivity disorder (ADHD) children: “true” depression or demoralization? J Affect Disord 47:113–122

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Faraone SV, Monuteaux MC, Bober M, Cadogen E (2004) Gender effects on attention-deficit/hyperactivity disorder in adults, revisited. Biol Psychiatry 55:692–700

    Article  PubMed  Google Scholar 

  • Biederman J, Monuteaux MC, Mick E, Spencer T, Wilens TE, Silva JM, Snyder LE, Faraone SV (2006) Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med 36:167–179

    Article  PubMed  Google Scholar 

  • Biederman J, Ball SW, Monuteaux MC, Mick E, Spencer TJ, Mc-Creary M, Cote M, Faraone SV (2008a) New insights into the comorbidity between ADHD and major depression in adolescent and young adult females. J Am Acad Child Adolesc Psychiatry 47:426–434

    Article  PubMed  Google Scholar 

  • Biederman J, Monuteaux MC, Spencer T, Wilens TE, Macpherson HA, Faraone SV (2008b) Stimulant therapy and risk for subsequent substance use disorders in male adults with ADHD: a naturalistic controlled 10-year follow-up study. Am J Psychiatry 165:597–603

    Article  PubMed  Google Scholar 

  • Biederman J, Petty CR, Monuteaux MC, Evans M, Parcell T, Faraone SV, Wozniak J (2009) The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis. J Clin Psychiatry 70:732–740

    Article  PubMed  Google Scholar 

  • Biederman J, Petty CR, Evans M, Small J, Faraone SV (2010) How persistent is ADHD? A controlled 10-year follow-up study of boys with ADHD. Psychiatry Res 177:299–304

    Article  PubMed  Google Scholar 

  • Blackman JA, Gurka MJ (2007) Developmental and behavioural comorbidity of asthma in children. J Dev Behav Pediatr 28:92–99

    Article  PubMed  Google Scholar 

  • Blackman GL, Ostrander R, Herman KC (2005) Children with ADHD and depression: a multisource, multimethod assessment of clinical, social, and academic functioning. J Atten Disord 8:195–207

    Article  PubMed  Google Scholar 

  • Bloch MH, Panza KE, Landeros-Weisenberger A, Leckman JF (2009) Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. J Am Acad Child Adolesc Psychiatry 48:884–893

    Article  PubMed  Google Scholar 

  • Bowen R, Chavira DA, Bailey K, Stein MT, Stein MB (2008) Nature of anxiety comorbid with attention deficit hyperactivity disorder in children from a pediatric primary care setting. Psychiatry Res 15(157):201–209

    Article  Google Scholar 

  • Braaten EB, Biederman J, Monuteaux MC, Mick E, Calhoun E, Cattan G et al (2003) Revisiting the association between attention-deficit/hyperactivity disorder and anxiety disorders: a familial risk analysis. Biol Psychiatry 53:93–99

    Article  PubMed  Google Scholar 

  • Brookshire BL, Butler IJ, Ewing-Cobbs L, Fletcher JM (1994) Neuropsychological characteristics of children with Tourette syndrome: evidence for a nonverbal learning disability? J Clin Exp Neuropsychol 16:289–302

    Article  CAS  PubMed  Google Scholar 

  • Brown CS (1991) Treatment of attention deficit hyperactivity disorder: a critical review. Drug Intell Clin Pharmacol 25:1207–1213

    CAS  Google Scholar 

  • Cardona F, Romano A, Bollea L, Chiarotti F (2004) Psychopathological problems in children affected by tic disorders—study on a large Italian population. Eur Child Adolesc Psychiatry 13:166–171

    Article  PubMed  Google Scholar 

  • Castellanos FX, Tannock R (2002) Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 3:617–628

    CAS  PubMed  Google Scholar 

  • Chang K, Nayar D, Howe M, Rana M (2009) Atomoxetine as an adjunct therapy in the treatment of comorbid attention-deficit/hyperactivity disorder in children and adolescents with bipolar I or II disorder. J Child Adolesc Psychopharmacol 19:547–551

    Article  PubMed  Google Scholar 

  • Cho SC, Kim JW, Choi HJ, Kim BN, Shin MS, Lee JH, Kim EH (2008) Associations between symptoms of attention deficit hyperactivity disorder, depression, and suicide in Korean female adolescents. Depress Anxiety 25:E142–E146

    Article  PubMed  Google Scholar 

  • Christiansen H, Chen W, Oades RD, Asherson P, Taylor EA, Lasky-Su J, Zhou K, Banaschewski T, Buschgens C, Franke B, Gabriels I, Manor I, Marco R, Müller UC, Mulligan A, Psychogiou L, Rommelse NN, Uebel H, Buitelaar J, Ebstein RP, Eisenberg J, Gill M, Miranda A, Mulas F, Roeyers H, Rothenberger A, Sergeant JA, Sonuga-Barke EJ, Steinhausen HC, Thompson M, Faraone SV (2008) Co-transmission of conduct problems with attention-deficit/hyperactivity disorder: familial evidence for a distinct disorder. J Neural Transm 115:163–175

    Article  CAS  PubMed  Google Scholar 

  • Cohen DJ, Brunn RD, Leckman JF (1988) Tourette’s syndrome and tic disorders. Wiley, New York

    Google Scholar 

  • Comings DE (1995) Role of genetic factors in depression based on studies of Tourette syndrome and ADHD probands and their relatives. Am J Med Genet 60:111–121

    Article  CAS  PubMed  Google Scholar 

  • Connor DF, Steeber J, McBurnett K (2010) A review of attention-deficit/hyperactivity disorder complicated by symptoms of oppositional defiant disorder or conduct disorder. J Dev Behav Pediatr JDBP 31:427–440

    Article  Google Scholar 

  • Cooperation-Group MTA- (1999a) A 14-month randomized clinical trial oftreatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56:1073–1086

    Article  Google Scholar 

  • Cooperation-Group MTA- (1999b) Moderators and mediators of treatment response for children with attention deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1088–1096

    Article  Google Scholar 

  • Corbett BA, Constantine LJ, Hendren R, Rocke D, Ozonoff S (2009) Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Res 166:210–222

    Article  PubMed  Google Scholar 

  • Corkum MA, Tannock R, Moldofsky H (1998) Sleep disturbances in children with attention-de.cit/hyperactivit y disorder. J Am Acad Child Adolesc Psychiatry 37:637–646

    Article  CAS  PubMed  Google Scholar 

  • Corkum P, Moldofsky H, Hogg-Johnson S, Humphries T, Tannock R (1999) Sleep problems in children with attention-deficit/hyperactivity disorder: impact of subtype, comorbidity and stimulant medication. J Am Acad Child Adolesc Psychiatry 38:1285–1293

    Article  CAS  PubMed  Google Scholar 

  • Cortese S, Faraone SV, Konofal E, Lecendreux M (2009) Sleep in children with attention-deficit/hyperactivity disorder: meta-analysis of subjective and objective studies. J Am Acad Child Adolesc Psychiatry 48:894–908

    Article  PubMed  Google Scholar 

  • Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A (2003) Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry 60:837–844

    Article  PubMed  Google Scholar 

  • Crimmins CR, Rathbun SR, Husmann DA (2003) Management of urinary incontinence and nocturnal enuresis in attention-deficit hyperactivity disorder. J Urol 170:1347–1350

    Article  CAS  PubMed  Google Scholar 

  • Davis C (2010) Attention-deficit/hyperactivity disorder: associations with overeating and obesity. Curr Psychiatr Rep 15 Jul 2010. [Epub ahead of print]

  • Daviss WB, Weinman DR, Diler RS, Birmaher B (2006) Risk factors for co-morbid depression in adolscents with ADHD. Poster presented at 53rd Annual Meeting of the American Academy of Child and Adolescent Psychiatry, San Diego, CA (abstract)

  • Daviss WB, Birmaher B, Diler RS, Mintz J (2008) Does pharmacotherapy for attention-deficit/hyperactivity disorder predict risk of later major depression? J Child Adolesc Psychopharmacol 18:257–264

    Article  PubMed  Google Scholar 

  • Diler RS, Uguz S, Seydaoglu G, Erol N, Avci A (2007) Differentiating bipolar disorder in Turkish prepubertal children with attention-deficit hyperactivity disorder. Bipolar Disord 9:243–251

    Article  PubMed  Google Scholar 

  • Döpfner M, Fröhlich J, Lehmkuhl G (2000) Hyperkinetische Störungen. Leitfaden Kinder- und Jugendpsychotherapie, Bd.1. Hogrefe, Göttingen

    Google Scholar 

  • Dopheide JA, Pliszka SR (2009) Attention-deficit-hyperactivity disorder: an update. Pharmacotherapy 29:656–679

    Article  PubMed  Google Scholar 

  • Drabick DA, Gadow KD, Sprafkin J (2006) Co-occurrence of conduct disorder and depression in a clinic-based sample of boys with ADHD. J Child Psychol Psychiatry 47:766–774

    Article  PubMed  Google Scholar 

  • Egger J, Carter CM, Graham PJ, Gumley D, Soothill JF (1985) Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet 1:540–545

    Article  CAS  PubMed  Google Scholar 

  • Egger J, Stolla A, McEwen LM (1992) Controlled trial of hyposensitisation in children with food-induced hyperkinetic syndrome. Lancet 339:1150–1153

    Article  CAS  PubMed  Google Scholar 

  • Elia J, Takeda T, Deberardinis R, Burke J, Accardo J, Ambrosini PJ, Blum NJ, Brown LW, Lantieri F, Berrettini W, Devoto M, Hakonarson H (2009) Nocturnal enuresis: a suggestive endophenotype marker for a subgroup of inattentive attention-deficit/hyperactivity disorder. J Pediatr 155:239.e5–244.e5

    Google Scholar 

  • European Food Safety Authority (2008) Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) on a request from the Commission on the results of the study by McCann et al. (2007) on the effect of some colours and sodium benzoate on children’s behaviour. EFSA J 660:1–54

    Google Scholar 

  • Fallgatter AJ, Jacob CP (2009) Comorbidity of substance use disorders and attention-deficit hyperactivity disorders: pathogenesis and therapy. Der Nervenarzt 80:1015–1021

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Biederman J (1997) Do attention deficit hyperactivity disorder and major depression share familial risk factors? J Nerv Ment Disord 185:533–541

    Article  CAS  Google Scholar 

  • Faraone SV, Biederman J, Jetton JG, Tsuang MT (1997a) Attention deficit disorder and conduct disorder: longitudinal evidence for a familial subtype. Psychol Med 27:291–300

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Biederman J, Mennin D, Wozniak J, Spencer T (1997b) Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype? J Am Acad Child Adolescent Psychiatry 36:1378–1387

    Article  CAS  Google Scholar 

  • Faraone SV, Tsuang MT, Tsuang DW (1999) Genetics and mental disorders: a guide for students, clinicians, and researchers. Guilford Press, New York

    Google Scholar 

  • Faraone SV, Biederman J, Monuteaux MC (2000) Attentiondeficit disorder and conduct disorder in girls: evidence for a familial subtype. Biol Psychiatry 48:21–29

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Biederman J, Monuteaux MC (2001) Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype? J Affect Disord 64:19–26

    Article  CAS  PubMed  Google Scholar 

  • Findling RL, Short EJ, McNamara NK, Demeter CA, Stansbrey RJ, Gracious BL, Whipkey R, Manos MJ, Calabrese JR (2007) Methylphenidate in the treatment of children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 46:1445–1453

    Article  PubMed  Google Scholar 

  • Fleming J, Levy L (2002) Eating disorders in women with AD/HD. In: Quinn PO, Nadeau KG (eds) Gender issues and AD/HD: research, diagnosis, and treatment. Advantage Books, Silver Springs, pp 411–426

    Google Scholar 

  • Flory K, Milich R, Lynam DR, Leukefeld C, Clayton R (2003) Relation between childhood disruptive behaviour disorders and substance use and dependence symptoms in young adulthood: individuals with symptoms of attention-deficit/hyperactivity disorder and conduct disorder are uniquely at risk. Psychol Addict Behav 17:151–158

    Article  PubMed  Google Scholar 

  • Fossati A, Novella L, Donati D, Donini M, Maffei C (2002) History of childhood attention deficit/hyperactivity disorder symptoms and borderline personality disorder: a controlled study. Compr Psychiatry 43:369–377

    Article  PubMed  Google Scholar 

  • Fox NA, Henderson HA (1999) Does infancy matter? Predicting social behaviour from infant temperament. Infant Behav Dev 22:445–455

    Article  Google Scholar 

  • Freeman RD, The Tourette Syndrome International Database Consortium (2007) Answers from a world-wide clinical dataset on Tourette syndrome. Eur Child Adolesc Psychiatry 16(Suppl 1):15–23

    Article  PubMed  Google Scholar 

  • Freitag CM (2007) The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry 12:2–22

    Article  CAS  PubMed  Google Scholar 

  • Freitag CM, Rohde L, Lempp T, Romanos M (2010) Phenotypic and measurement influences on heritability estimates in childhood ADHD. Eur Child Adolesc Psychiatry 19:311–323

    Article  PubMed  Google Scholar 

  • Frodl T (2010) Comorbidity of ADHD and substance use disorder (SUD): a neuroimaging perspective. J Atten Disord (May 21) [Epub ahead of print]

  • Gadow KD, Nolan EE, Sverd J, Sprafkin J, Schwartz J (2002) Anxiety and depression symptoms and response to methylphenidate in children with attention-deficit hyperactivity disorder and tic disorder. J Clin Psychopharmacol 22:267–274

    Article  CAS  PubMed  Google Scholar 

  • Gadow KD, Devincent CJ, Drabick DA (2008) Oppositional defiant disorder as a clinical phenotype in children with autism spectrum disorder. J Autism Dev Disord 38:1302–1310

    Article  PubMed  Google Scholar 

  • Gayán J, Willcutt EG, Fisher SE, Francks C, Cardon LR, Olson RK, Pennington BF, Smith SD, Monaco AP, DeFries JC (2005) Bivariate linkage scan for reading disability and attention-deficit/hyperactivity disorder localizes pleiotropic loci. J Child Psychol Psychiatry 46:1045–1056

    Article  PubMed  Google Scholar 

  • Geller D, Biederman J, Faraone SV, Frazier J, Coffey BJ, Kim G, Bellordre CA (2000) Clinical correlates of obsessive compulsive disorder in children and adolescents referred to specialized and non-specialized clinical settings. Depress Anxiety 11:163–168

    Article  CAS  PubMed  Google Scholar 

  • Geller B, Zimerman B, Williams M et al (2002a) DSM-IV mania symptoms in a prepubertal and early onset bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 12:11–25

    Article  PubMed  Google Scholar 

  • Geller DA, Biederman J, Faraone SV, Cradock K, Hagermoser L, Zaman N, Frazier JA, Coffey BJ, Spencer TJ (2002b) Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: fact or artifact? J Am Acad Child Adolesc Psychiatry 41:52–58

    Article  PubMed  Google Scholar 

  • Geller DA, Coffey B, Faraone S, Hagermoser L, Zaman NK, Farrell CL et al (2003) Does comorbid attention-deficit/hyperactivity disorder impact the clinical expression of pediatric obsessive-compulsive disorder? CNS Spectr 8:259–264

    PubMed  Google Scholar 

  • Geller D, Donnelly C, Lopez F, Rubin R, Newcorn J, Sutton V, Bakken R, Paczkowski M, Kelsey D, Sumner C (2007a) Atomoxetine treatment for pediatric patients with attention-deficit/hyperactivity disorder with comorbid anxiety disorder. J Am Acad Child Adolesc Psychiatry 46:1119–1127

    Article  PubMed  Google Scholar 

  • Geller D, Petty C, Vivas F, Johnson J, Pauls D, Biederman J (2007b) Further evidence for co-segregation between pediatric obsessive compulsive disorder and attention deficit hyperactivity disorder: a familial risk analysis. Biol Psychiatry 61:1388–1394

    Article  PubMed  Google Scholar 

  • Ghanizadeh A (2010) Comorbidity of enuresis in children with attention-deficit/hyperactivity disorder. J Atten Disord 13:464–467

    Article  PubMed  Google Scholar 

  • Gilger JW, Pennington BF, DeFries JC (1992) A twin study of the aetiology of comorbidity: attention-deficit hyperactivity disorder and dyslexia. J Am Acad Child Adolesc Psychiatry 31:343–348

    Article  CAS  PubMed  Google Scholar 

  • Gillberg C, Gillberg IC, Rasmussen P, Kadesjo B, Soderstrom H, Rastam M, Johnson M, Rothenberger A, Niklasson L (2004) Co-existing disorders in ADHD—implications for diagnosis and intervention. Eur Child Adolesc Psychiatry 13:180–192

    Article  Google Scholar 

  • Gordon SM, Tulak F, Troncale J (2004) Prevalence and characteristics of adolescents patients with co-occurring ADHD and substance dependence. J Addict Dis 23:31–40

    Article  PubMed  Google Scholar 

  • Gorman EB, Klorman R, Thatcher JE, Borgstedt AD (2006) Effects of methylphenidate on subtypes of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45:808–816

    Article  PubMed  Google Scholar 

  • Grados MA, Mathews CA (2008) Latent class analysis of Gilles de la Tourette syndrome using comorbidity: clinical and genetic implications. Biol Psychiatry 64:219–225

    Article  PubMed  Google Scholar 

  • Grados MA, Mathews CA (2009) Clinical phenomenology and phenotype variability in Tourette syndrome. J Psychosom Res 67:491–496

    Article  PubMed  Google Scholar 

  • Greven C, Harlaar H, Plomin R (2009) Genetic overlap between ADHD and reading is driven by inattentiveness and its relations to aspects of reading, rather than by hyperactivity-impulsivity. Abstract. ADHD 1:119

    Google Scholar 

  • Groman SM, James AS, Jentsch JD (2009) Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder. Neurosci Biobehav Rev 33:690–698

    Article  PubMed  Google Scholar 

  • Guttmann-Steinmetz S, Gadow KD, Devincent CJ (2009) Oppositional defiant and conduct disorder behaviours in boys with autism spectrum disorder with and without attention-deficit hyperactivity disorder versus several comparison samples. J Autism Dev Disord 39:976–985

    Article  PubMed  Google Scholar 

  • Guttmann-Steinmetz S, Gadow KD, Devincent CJ, Crowell J (2010) Anxiety symptoms in boys with autism spectrum disorder, attention-deficit hyperactivity disorder, or chronic multiple tic disorder and community controls. J Autism Dev Disord Feb 9 [Epub ahead of print]

  • Hebebrand J, Dempfle A, Saar K, Thiele H, Herpertz-Dahlmann B, Linder M, Kiefl H, Remschmidt H, Hemminger U, Warnke A, Knölker U, Heiser P, Friedel S, Hinney A, Schäfer H, Nürnberg P, Konrad K (2006) A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs. Mol Psychiatry 11:196–205

    Google Scholar 

  • Hesslinger B, Tebartz van Elst L, Mochan F, Ebert D (2003) A psychopathological study into the relationship between attention deficit hyperactivity disorder in adult patients and recurrent brief depression. Acta Psychiatr Scand 107:385–389

    Article  CAS  PubMed  Google Scholar 

  • Himle MB, Woods DW (2005) An experimental evaluation of tic suppression and the tic rebound effect. Behav Res Ther 43:1443–1451

    Article  PubMed  Google Scholar 

  • Hirshfeld-Becker DR, Biederman J, Calltharp S, Rosenbaum ED, Faraone SV, Rosenbaum JF (2003) Behavioral inhibition and disinhibition as hypothesized precursors to psychopathology: implications for pediatric bipolar disorder. Biol Psychiatry 53:985–999 (review)

    Google Scholar 

  • Hoekstra PJ, Steenhuis MP, Troost PW, Korf J, Kallenberg CG, Minderaa RB (2004) Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioural problems in tic disorders. J Dev Behav Pediatr 25:272–279

    Article  PubMed  Google Scholar 

  • Holtkamp K, Konrad K, Müller B, Heussen N, Herpertz S, Herpertz-Dahlmann B, Hebebrand J (2004) Overweight and obesity in children with Attention-Deficit/Hyperactivity Disorder. Int J Obes 28:685–689

    Article  CAS  Google Scholar 

  • Holtmann M, Bölte S, Poustka F (2005) ADHD, Asperger syndrome, and high-functioning autism. J Am Acad Child Adolesc Psychiatry 44:1101

    Article  PubMed  Google Scholar 

  • Holtmann M, Bolte S, Poustka F (2007) Attention deficit hyperactivity disorder symptoms in pervasive developmental disorders: association with autistic behaviour domains and coexisting psychopathology. Psychopathology 40:172–177

    Article  PubMed  Google Scholar 

  • Holtmann M, Goth K, Wöckel L, Poustka F, Bölte S (2008) CBCL-pediatric bipolar disorder phenotype: severe ADHD or bipolar disorder? J Neural Transm 115:155–161

    Article  CAS  PubMed  Google Scholar 

  • Hudziak JJ, Heath AC, Madden PF, Reich W, Bucholz KK, Slutske W, Bierut LJ, Neuman RJ, Todd RD (1998) Latent class and factor analysis of DSM-IV ADHD: a twin study of female adolescents. J Am Acad Child Adolesc Psychiatry 37:848–857

    Article  CAS  PubMed  Google Scholar 

  • Huss M, Hölling H, Kurth BM, Schlack R (2008) How often are German children and adolescents diagnosed with ADHD? Prevalence based on the judgment of health care professionals: results of the German health and examination survey (KiGGS). Eur Child Adolesc Psychiatry (Suppl) 1:52–58

    Article  Google Scholar 

  • Jacob CP, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, Reif A, Walitza S, Romanos M, Strobel A, Brocke B, Schäfer H, Schmidtke A, Böning J, Lesch KP (2007) Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci 257:309–317

    Article  PubMed  Google Scholar 

  • Jain M, Palacio LG, Castellanos FX, Palacio JD, Pineda D, Restrepo MI, Muñoz JF, Lopera F, Wallis D, Berg K, Bailey-Wilson JE, Arcos-Burgos M, Muenke M (2007) Attention-deficit/hyperactivity disorder and comorbid disruptive behaviour disorders: evidence of pleiotropy and new susceptibility loci. Biol Psychiatry 61:1329–1339

    Article  CAS  PubMed  Google Scholar 

  • James A, Lai FH, Dahl C (2004) Attention deficit hyperactivity disorder and suicide: a review of possible associations. Acta Psychiatr Scand 110:408–415

    Article  CAS  PubMed  Google Scholar 

  • Jarrett MA, Ollendick TH (2008) A conceptual review of the comorbidity of attention-deficit/hyperactivity disorder and anxiety: implications for future research and practice. Clin Psychol Rev 28:1266–1280

    Article  PubMed  Google Scholar 

  • Jensen PS, Martin D, Cantwell DP (1997) Comorbidity in ADHD: Implications for research, practice, and DSM-IV. J Am Acad Child Adoles Psychiatry 36:1065–1079

    Article  CAS  Google Scholar 

  • Jensen PS, Hinshaw SP, Kraemer HC, Lenora N, Newcorn JH, Abikoff HB et al (2001) ADHD comorbidity findings from the MTA Study: Comparing comorbid subgroups. J Am Acad Child Adoles Psychiatry 40:147–158

    Article  CAS  Google Scholar 

  • Johnston BD, Wright JA (1993) Attentional dysfunction in children with encopresis. J Dev Behav Pediatr 14:381–385

    Article  CAS  PubMed  Google Scholar 

  • Katusic SK, Barbaresi WJ, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ (2005) Psychostimulant treatment and risk for substance abuse among young adults with a history of attention-deficit/hyperactivity disorder: a population-based, birth cohort study.

  • Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988

    Article  CAS  PubMed  Google Scholar 

  • Keenan K, Shaw DS (2003) Starting at the beginning: exploring the etiology of antisocial behavior in the first years of life. In: Lahey BB, Moffitt TE, Caspi A (eds) The causes of conduct disorder and serious delinquency. Guilford, New York, pp 153–181

    Google Scholar 

  • Kent L, Craddock N (2003) Is there a relationship between attention deficit hyperactivity disorder and bipolar disorder? J Affect Disord 73:211–221

    Article  PubMed  Google Scholar 

  • Kessler RC, Crum RM, Warner LA, Nelson CB, Schulenberg J, Anthony JC (1997) Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch Gen Psychiatry 54:313–321

    CAS  PubMed  Google Scholar 

  • Kessler R, Adler L, Barkley R, Biederman J, Conners C, Demler O, Faraone S, Greenhill L, Howes M, Secnik K, Spencer TJ, Ustun T, Walters E, Zaslavsky A (2006) The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163:716–723

    Article  PubMed  Google Scholar 

  • Keulers EH, Hendriksen JG, Feron FJ, Wassenberg R, Wuisman-Frerker MG, Jolles J, Vles JS (2007) Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: an unblinded clinical trial. Eur J Paediatr Neurol 11:21–28

    Article  PubMed  Google Scholar 

  • Khalifa N, von Knorring AL (2006) Psychopathology in a Swedish population of school children with tic disorders. J Am Acad Child Adolesc Psychiatry 45:1346–1353

    Article  PubMed  Google Scholar 

  • Kovacs M, Akiskal HS, Gatsonis C, Parrone PL (1994) Childhood-onset dysthymic disorder. Clinical features and prospective naturalistic outcome. Arch Gen Psychiatry 51:365–374

    CAS  PubMed  Google Scholar 

  • Kowatch RA, Youngstorm EA, Danielyan A, Findling RL (2005) Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord 4:483–496

    Article  Google Scholar 

  • Kuczenski R, Segal DS (2005) Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse. Biol Psychiatry 57:1391–1396

    Article  CAS  PubMed  Google Scholar 

  • Kunwar A, Dewan M, Faraone SV (2007) Treating common psychiatric disorders associated with attention-deficit/hyperactivity disorder. Exp Opin Pharmacother 8:555–562

    Article  CAS  Google Scholar 

  • Lahey BB, Loeber R, Quay HC, Applegate B, Shaffer D, Waldman I, Hart EL, McBurnett K, Frick PJ, Jensen PS, Dulcan MK, Canino G, Bird HR (1998) Validity of DSM-IV subtypes of conduct disorder based on age of onset. J Am Acad Child Adoles Psychiatry 37:435–442

    Article  CAS  Google Scholar 

  • Lahey BB, Loeber R, Burke JD, Applegate B (2005) Predicting future antisocial personality disorder in males from a clinical assessment in childhood. J Consult Clin Psychol 73:389–399

    Article  PubMed  Google Scholar 

  • Lampe K, Konrad K, Kroener S, Fast K, Kunert HJ, Herpertz SC (2007) Neuropsychological and behavioural disinhibition in adult ADHD compared to borderline personality disorder. Psychol Med 37:1717–1729

    Article  CAS  PubMed  Google Scholar 

  • Lara C, Fayyad J, de Graaf R, Kessler RC, Aguilar-Gaxiola S, Angermeyer M, Demytteneare K, de Girolamo G, Haro JM, Jin R, Karam EG, Lépine JP, Mora ME, Ormel J, Posada-Villa J, Sampson N (2009) Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey. Initiative Biol Psychiatry 65:46–54

    Google Scholar 

  • Lazar JW, Frank Y (1998) Frontal systems dysfunction in children with attention-deficit/hyperactivity disorder and learning disabilities. J Neuropsychiatry Clin Neurosci 10:160–167

    CAS  PubMed  Google Scholar 

  • Leckman JF (2003) Phenomenology of tics and natural history of tic disorders. Brain Dev 25(Suppl 1):24–28

    Google Scholar 

  • Lesch K-P, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Walitza S, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Romanos J, Gross-Lesch S, Zerlaut H, Wultsch T, Heinzel S, Fassnacht M, Fallgatter A, Allolio B, Schäfer H, Warnke A, Reif A, Ropers H-H, Ullmann R (2010) Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry (Mar 23) [Epub ahead of print]

  • Levy LD, Fleming JP, Klar D (2009) Treatment of refractory obesity in severely obese adults following management of newly diagnosed attention deficit hyperactivity disorder. Int J Obes (Lond) 33:326–334

    Article  CAS  Google Scholar 

  • Loeber R, Green SM, Keenan K, Lahey BB (1995) Which boys will fare worse? Early predictors of the onset of conduct disorder in a six-year longitudinal study. J Am Acad Child Adolesc Psychiatry 34:499–509

    Article  CAS  PubMed  Google Scholar 

  • Loeber R, Green SM, Lahey BB, Frick PJ, McBurnett K (2000) Findings on disruptive behaviour disorders from the first decade of the Developmental Trends Study. Clin Child Fam Psychol Rev 3:37–60

    Article  CAS  PubMed  Google Scholar 

  • Loeber R, Burke J, Pardini DA (2009) Perspectives on oppositional defiant disorder, conduct disorder, and psychopathic features. J Child Psychol Psychiatry 50:133–142

    Article  PubMed  Google Scholar 

  • Mague SD, Andersen SL, Carlezon WA (2005) Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats. Biol Psychiatry 57:120–125

    Article  CAS  PubMed  Google Scholar 

  • Mannuzza S, Klein RG, Addalli KA (1991) Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study. J Am Acad Child Adolesc Psychiatry 30:743–751

    Article  CAS  PubMed  Google Scholar 

  • Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M (1993) Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 50:565–576

    CAS  PubMed  Google Scholar 

  • Mannuzza S, Klein RG, Moulton JL (2003) Persistence of attention-deficit/hyperactivity disorder into adulthood: what have we learned from the prospective follow-up studies? J Attention Dis 7:93–100

    Article  Google Scholar 

  • Mannuzza S, Klein RG, Moulton JL (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Res 160:237–246

    Article  PubMed  Google Scholar 

  • Manor I, Gutnik I, Ben-Dor DH, Apter A, Sever J, Tyano S, Weizman A, Zalsman G (2010) Possible association between attention deficit hyperactivity disorder and attempted suicide in adolescents - a pilot study. Eur Psychiatry 25:146–150

    Article  CAS  PubMed  Google Scholar 

  • Marks DJ, Newcorn JH, Halperin JM (2001) Comorbidity in adults with attention-deficit/hyperactivity disorder. Ann N Y Acad Sci 931:216–238

    Article  CAS  PubMed  Google Scholar 

  • Martino D, Defazio G, Giovannoni G (2009) The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. J Psychosom Res 67:547–557

    Article  PubMed  Google Scholar 

  • Masi G, Millepiedi S, Mucci M, Bertini N, Pfanner C, Arcangeli F (2006) Comorbidity of obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents. Compr Psychiatry 47:42–47

    Article  PubMed  Google Scholar 

  • Mattis S, Papolos D, Luck D, Cockerham M, Thode HC Jr (2010) Neuropsychological factors differentiating treated children with pediatric bipolar disorder from those with attention-deficit/hyperactivity disorder. J Clin Exp Neuropsychol 5:1–11

    Article  Google Scholar 

  • McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, Kitchin E, Lok K, Porteous L, Prince E, Sonuga-Barke E, Warner JO, Stevenson J (2007) Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet 370:1560–1567

    Article  CAS  PubMed  Google Scholar 

  • McGough JJ, Smalley SL, McCracken JT, Yang M, Del’Homme M, Lynn DE, Loo S (2005) Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex families. Am J Psychiatry 162:1621–1627

    Article  PubMed  Google Scholar 

  • Mehler-Wex C, Scheuerpflug P, Peschke N, Roth M, Reitzle K, Warnke A (2005) Z [Encopresis–predictive factors and outcome] [Article in German]. Kinder Jugendpsychiatr Psychother 33:285–293

    Google Scholar 

  • Mick E, Faraone SV (2008) Genetics of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 17:261–284

    Article  PubMed  Google Scholar 

  • Milberger S, Biederman J, Faraone SV, Murphy J, Tsuang MT (1995) Attention deficit hyperactivity disorder and comorbid disorders: issues of overlapping symptoms. Am J Psychiatry 152:1793–1799

    CAS  PubMed  Google Scholar 

  • Milberger S, Biederman J, Faraone SV, Chen L, Jones J (1997) Further evidence of an association between attention-deficit/hyperactivity disorder and cigarette smoking. Findings from a high-risk sample of siblings. Am J Addict 6:205–217

    CAS  PubMed  Google Scholar 

  • Miller CJ, Flory JD, Miller SR, Harty SC, Newcorn JH, Halperin JM (2008) Childhood attention-deficit/hyperactivity disorder and the emergence of personality disorders in adolescence: a prospective follow-up study. J Clin Psychiatry 69:1477–1484

    Google Scholar 

  • Moffitt TE (1993) Adolescence-limited and lifecourse- persistent antisocial behavior: a developmental taxonomy. Psychol Rev 100:674–701

    Article  CAS  PubMed  Google Scholar 

  • Molina BSG, Flory K, Hinshaw SP, Greiner AR, Arnold LE, Swanson JM, Hechtman L, Jensen PS, Vitiello B, Hoza B, Pelham WE, Elliott GR, Wells KC, Abikoff HB, Gibbons RD, Marcus S, Conners CK, Epstein JN, Greenhill LL, March JS, Newcorn JH, Severe JB, Wigal T (2007) Delinquent behaviour and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effects. J Am Acad Child Adolesc Psychiatry 46:1028–1040

    Article  PubMed  Google Scholar 

  • Moore CM, Biederman J, Wozniak J, Mick E, Aleardi M, Wardrop M, Dougherty M, Harpold T, Hammerness P, Randall E, Renshaw PF (2006) Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study. Am J Psychiatry 163:316–318

    Article  PubMed  Google Scholar 

  • Mulligan A, Anney RJ, O’Regan M, Chen W, Butler L, Fitzgerald M, Buitelaar J, Steinhausen HC, Rothenberger A, Minderaa R, Nijmeijer J, Hoekstra PJ, Oades RD, Roeyers H, Buschgens C, Christiansen H, Franke B, Gabriels I, Hartman C, Kuntsi J, Marco R, Meidad S, Mueller U, Psychogiou L, Rommelse N, Thompson M, Uebel H, Banaschewski T, Ebstein R, Eisenberg J, Manor I, Miranda A, Mulas F, Sergeant J, Sonuga-Barke E, Asherson P, Faraone SV, Gill M (2009) Autism symptoms in Attention-Deficit/Hyperactivity Disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. J Autism Dev Disord 39:197–209

    Article  PubMed  Google Scholar 

  • Mustillo S, Worthman C, Erkanli A, Keeler G, Angold A, Costello EJ (2003) Obesity and psychiatric disorder: developmental trajectories. Pediatrics 111:851–859

    Article  PubMed  Google Scholar 

  • Neale MC, Kendler KS (1995) Models of comorbidity for multifactorial disorders. Am J Hum Genet 57:935–953

    CAS  PubMed  Google Scholar 

  • Neuman RJ, Todd RD, Heath AC, Reich W, Hudziak JJ, Bucholz KK, Madden PA, Begleiter H, Porjesz B, Kuperman S, Hesselbrock V, Reich T (1999) Evaluation of ADHD typology in three contrasting samples: a latent class approach. J Am Acad Child Adolesc Psychiatry 38:25–33

    Article  CAS  PubMed  Google Scholar 

  • Nierenberg AA, Miyahara S, Spencer T, Wisniewski SR, Otto MW, Simon N, Pollack MH, Ostacher MJ, Yan L, Siegel R, Sachs GS (2005) STEP-BD Investigators. Clinical and diagnostic implications of lifetime attentiondeficit/hyperactivity disorder comorbidity in adults with bipolar disorder. Biol Psychiatry 57:1467–1473

    Article  PubMed  Google Scholar 

  • Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJ (2005) Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 57:1224–1230

    Article  PubMed  Google Scholar 

  • Nock MK, Kazdin AE, Hiripi E, Kessler RC (2007) Lifetime prevalence, correlates, and persistence of oppositional defiant disorder: Results from the National Comorbidity Survey Replication. J Child Psychol Psychiatry 48:703–713

    Article  PubMed  Google Scholar 

  • Ollendick TH, Jarrett MA, Grills-Taquechel AE, Hovey LD, Wolff JC (2008) Comorbidity as a predictor and moderator of treatment outcome in youth with anxiety, affective, attention deficit/hyperactivity disorder, and oppositional/conduct disorders. Clin Psychol Rev 28:1447–1471

    Article  PubMed  Google Scholar 

  • Orth M, Rothwell JC (2009) Motor cortex excitability and comorbidity in Gilles de la Tourette syndrome. J Neurol Neurosurg Psychiatry 80:29–34

    Google Scholar 

  • Ostrander R, Crystal DS, August G (2006) Attention deficit-hyperactivity disorder, depression, and self- and other-assessments of social competence: a developmental study. J Abnorm Child Psychol 34:773–787

    Article  PubMed  Google Scholar 

  • Pagoto SL, Curtin C, Lemon SC, Bandini LG, Schneider KL, Bodenlos JS, Ma Y (2009) Association between adult attention deficit/hyperactivity disorder and obesity in the US population. Obesity (Silver Spring) 17:539–544

    Article  Google Scholar 

  • Paslakis G, Kiefer F, Diehl A, Alm B, Sobanski E (2010) Methylphenidate. Therapy option for adults with ADHD and comorbid substance use disorder? Der Nervenarzt 81:277–288

    Article  CAS  PubMed  Google Scholar 

  • Patterson GR, DeBaryshe BD, Ramsey E (1989) A developmental perspective on antisocial behaviour. Am Psychol 44:329–335

    Article  CAS  PubMed  Google Scholar 

  • Pauls DL, Leckman JF, Cohen DJ (1993) Familial relationship between Gilles de la Tourette’s syndrome, attention deficit disorder, learning disabilities, speech disorders, and stuttering. J Am Acad Child Adolesc Psychiatry 32:1044–1050

    Article  CAS  PubMed  Google Scholar 

  • Pelsser L, Buitelaar J, Savelkoul H (2009) ADHD as a (non) allergic hypersensitivity disorder: A hypothesis. Pediatr Allergy Immunol 20:107–112

    Article  PubMed  Google Scholar 

  • Pennington BF, Groisser D, Welsh MC (1993) Contrasting cognitive deficits in attention deficit hyperactivity disorder versus reading disability. Development Psychology 29:511–523

    Article  Google Scholar 

  • Peterson BS, Pine DS, Cohen P, Brook JS (2001) Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry 40:685–695

    Article  CAS  PubMed  Google Scholar 

  • Philipsen A, Limberger MF, Lieb K, Feige B, Kleindienst N, Ebner-Priemer U, Barth J, Schmahl C, Bohus M (2008) Attention-deficit hyperactivity disorder as a potentially aggravating factor in borderline personality disorder. Br J Psychiatry 192:118–123

    Article  PubMed  Google Scholar 

  • Plattner B, The SS, Kraemer HC, Williams RP, Bauer SM, Kindler J, Feucht M, Friedrich MH, Steiner H (2007) Suicidality, psychopathology, and gender in incarcerated adolescents in Austria. J Clin Psychiatry 68:1593–1600

    Article  PubMed  Google Scholar 

  • Pliszka SR (2000) Patterns of psychiatric comorbidity with attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 9:525–540

    CAS  PubMed  Google Scholar 

  • Plizka SR (1987) Tricyclic antidepressants in the treatment of children with attention deficit disorder. J Am Acad Child Adolesc Psychiatry 26:127–132

    Article  Google Scholar 

  • Plizka SR (1989) Effect of anxiety on cognition, behaviour and stimulant response in ADHD. J Am Acad Child Adolesc Psychiatry 28:882–887

    Article  Google Scholar 

  • Plizka SR (1992) Comorbidity of attention deficit hyperactivity disorder and overanxious disorder. J Am Acad Child Adolesc Psychiatry 31:197–203

    Article  Google Scholar 

  • Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis Am J Psychiatry 164:942–948

    Google Scholar 

  • Pomerleau OF, Downey KK, Stelson FW, Pomerleau CS (1995) Cigarette smoking in adult patients diagnosed with attention deficit hyperactivity disorder. J Subst Abuse 7:373–378

    Article  CAS  PubMed  Google Scholar 

  • Quinn PO (2008) Attention-deficit/hyperactivity disorder and its comorbidity in women and girls: an evolving picture. Curr Psychiatry Rep 10:419–423

    Article  PubMed  Google Scholar 

  • Randolph C, Hyde TM, Gold JM, Goldberg TE, Weinberger DR (1993) Tourette’s syndrome in monozygotic twins. Relationship of tic severity to neuropsychological function. Arch Neurol 50:725–728

    CAS  PubMed  Google Scholar 

  • Rasmussen ER, Todd RD, Neuman RJ, Heath AC, Reich W, Rohde LA (2002) Comparison of male adolescent-report of attention-deficit/hyperactivity disorder (ADHD) symptoms across two cultures using latent class and principal components analysis. J Child Psychol Psychiatry 43:797–805

    Google Scholar 

  • Rasmussen ER, Neuman RJ, Heath AC, Levy F, Hay DA, Todd RD (2004) Familial clustering of latent class and DSM-IV defined attention-deficit/hyperactivity disorder (ADHD) subtypes. J Child Psychol Psychiatry 45:589–598

    Article  PubMed  Google Scholar 

  • Remschmidt H (2003) Die Bedeutung von Entwicklungsprozessen für die Manifestation psychischer Störungen. In: Herpertz-Dahlmann B, Resch F, Schulte Markwort M, Warnke A (eds) Entwicklungspsychiatrie. Schattauer, Stuttgart, pp 257–268

    Google Scholar 

  • Rhee SH, Waldman I (2002) Genetic and environmental influences on antisocial behaviour: a meta-analysis of twin and adoption studies. Psychol Bull 128:490–529

    Article  PubMed  Google Scholar 

  • Rhee SH, Willcutt EG, Hartman CA, Pennington BF, DeFries JC (2008) Test of alternative hypotheses explaining the comorbidity between attention-deficit/hyperactivity disorder and conduct disorder. J Abnorm Child Psychol 36:29–40

    Article  PubMed  Google Scholar 

  • Robertson MM (2006) Attention deficit hyperactivity disorder, tics and Tourette’s syndrome: the relationship and treatment implications: a commentary. Eur Child Adolesc Psychiatry 15:1–11

    Article  PubMed  Google Scholar 

  • Robins LN, Price RK (1991) Adult disorders predicted by childhood conduct problems: Results from the NIMH Epidemiologic Catchment Area Project. Psychiatry 54:116–132

    CAS  PubMed  Google Scholar 

  • Robson WL, Jackson HP, Blackhurst D, Leung AK (1997) Enuresis in children with attention-deficit hyperactivity disorder. South Med J 90:503–505

    CAS  PubMed  Google Scholar 

  • Rodriguez A (2010) Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry 51:134–143

    Article  PubMed  Google Scholar 

  • Rodriguez A, Miettunen J, Henriksen TB, Olsen J, Obel C, Taanila A, Ebeling H, Linnet KM, Moilanen I, Järvelin MR (2008) Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes (Lond) 32:550–557

    Article  CAS  Google Scholar 

  • Roessner V, Robatzek M, Knapp G, Banaschewski T, Rothenberger A (2006) First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulants. Dev Med Child Neurol 48:616–621

    Article  PubMed  Google Scholar 

  • Roessner V, Becker A, Banaschewski T, Rothenberger A (2007) Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive Effects. J Abnorm Child Psychol 35:79–85

    Article  PubMed  Google Scholar 

  • Rohde P, Lewinsohn PM, Seeley JR (1991) Co-morbidity of unipolar depression: II. Co-morbidity with other mental disorders in adolescents and adults. J Abnorm Psychol 100:214–222

    Article  CAS  PubMed  Google Scholar 

  • Rohde P, Clarke GN, Lewinsohn PM, Seeley JR, Kaufman NK (2001) Impact of comorbidity on a cognitive-behavioural group treatment for adolescent depression. J Am Acad Child Adolesc Psychiatry 40:795–802

    Article  CAS  PubMed  Google Scholar 

  • Rolf J, Read PB (1984) Programs advancing developmental psychopathology. Child Dev 55:8–16

    Article  CAS  PubMed  Google Scholar 

  • Romanos M, Gerlach M, Warnke A, Schmitt J (2009) Association of attention-deficit/hyperactivity disorder and atopic eczema modified by sleep disturbance in a large population-based sample. J Epidemiol Community Health 64:269–273

    Article  PubMed  Google Scholar 

  • Rommelse NN, Franke B, Geurts HM, Hartman CA, Buitelaar JK (2010) Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry 19:281–295

    Article  PubMed  Google Scholar 

  • Rösler M, Retz W, Retz-Junginger P, Hengesch G, Schneider M, Supprian T, Schwitzgebel P, Pinhard K, Dovi-Akue N, Wender P, Thome J (2004) Prevalence of attention deficit-/hyperactivity disorder (ADHD) and comorbid disorders in young male prison inmates. Eur Arch Psychiatry Clin Neurosci 254:365–371

    Article  PubMed  Google Scholar 

  • Rutter M (1980) Developmental Psychiatry. Heinemann, London

    Google Scholar 

  • Rydén E, Thase ME, Stråht D, Aberg-Wistedt A, Bejerot S, Landén M (2009) A history of childhood attention-deficit hyperactivity disorder (ADHD) impacts clinical outcome in adult bipolar patients regardless of current ADHD. Acta Psychiatr Scand 120:239–246

    Article  PubMed  Google Scholar 

  • Sadeh A, Pergamin L, Bar-Haim Y (2006) Sleep in children with attention-deficit hyperactivity disorder: a meta-analysis of polysomnographic studies. Sleep medicine reviews 10:381–398

    Article  PubMed  Google Scholar 

  • Satterfield JH, Schell A (1997) A prospective study of hyperactive boys with conduct problems and normal boys: adolescent and adult criminality. J Am Acad Child Adolesc Psychiatry 36:1726–1735

    Article  CAS  PubMed  Google Scholar 

  • Schmitt J, Buske-Kirschbaum A, Rössner V. Is atopic disease a risk factor for attention-deficit/hyperactivity disorder? A systematic review. Allergy (in press)

  • Schmitt J, Chen C-M, Apfelbacher C, Romanos M, Heinrich J, and the LISA-plus Study Group Infant eczema, infant sleeping problems and mental health at age 10 years: The prospective birth-cohort study LISAplus. Allergy (in press)

  • Schmitt J, and Romanos M (2009) Lack of studies investigating the association of childhood eczema, sleeping problems, and attention-deficit/hyperactivity disorder. Pediatr Allergy Immunol.

  • Schmitt J, Romanos M, Pfennig A, Leopold K, Meurer M (2009a) Psychiatric comorbidity in adult eczema. Br J Dermatol 20:299–300

    Google Scholar 

  • Schmitt J, Romanos M, Schmitt NM, Meurer M, Kirch W (2009b) Atopic eczema and attention-deficit/hyperactivity disorder in a population-based sample of children and adolescents. JAMA 301:724–726

    Article  CAS  PubMed  Google Scholar 

  • Schmitt J, Apfelbacher C, Chen C-M, Romanos M, Sausenthaler S, Koletzko S, Bauer C-P, Hoffmann U, Krämer U, Berdel D, von Berg A, Wichmann H-E, Heinrich J, GINIpS Group (2010) Infant-onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention plus). J Allergy Clin Immunol 125:404–410

    Article  PubMed  Google Scholar 

  • Schneider J, Gadow KD, Crowell JA, Sprafkin J (2009) Anxiety in boys with attention-deficit/hyperactivity disorder with and without chronic multiple tic disorder. J Child Adolesc Psychopharmacol 19:737–748

    Article  PubMed  Google Scholar 

  • Schulte-Körne G, Warnke A, Remschmidt H (2006) [Genetics of dyslexia]. Z Kinder Jugendpsychiatr Psychother 34:435–444

    Google Scholar 

  • Schultz RT, Carter AS, Gladstone M, Scahill L, Leckman JF, Peterson BS, Zhang H, Cohen DJ, Pauls D (1998) Visual-motor integration functioning in children with Tourette syndrome. Neuropsychology 12:134–145

    Article  CAS  PubMed  Google Scholar 

  • Semiz UB, Basoglu C, Oner O, Munir KM, Ates A, Algul A, Ebrinc S, Cetin M (2008) Effects of diagnostic comorbidity and dimensional symptoms of attention-deficit-hyperactivity disorder in men with antisocial personality disorder. Aust N Z J Psychiatry 42:405–413

    Article  PubMed  Google Scholar 

  • Semrud-Clikeman M, Biederman J, Sprich-Buckminster S, Lehman BK, Faraone SV, Norman D (1992) Comorbidity between ADDH and learning disability: a review and report in a clinically referred sample. J Am Acad Child Adolesc Psychiatry 31:439–448

    Article  CAS  PubMed  Google Scholar 

  • Sevecke K, Lehmkuhl G, Krischer MK (2008) [Attention-deficit hyperactivity disorder and personality disorders in treated in-patient and incarcerated adolescents]. Prax Kinderpsychol Kinderpsychiatr 57:641–661

    Google Scholar 

  • Sharp SI, McQuillin A, Gurling HM (2009) Genetics of attention-deficit hyperactivity disorder (ADHD). Neuropharmacology 57:590–600

    Article  CAS  PubMed  Google Scholar 

  • Shreeram S, He JP, Kalaydjian A, Brothers S, Merikangas KR (2009) Prevalence of enuresis and its association with attention-deficit/hyperactivity disorder among US children: results from a nationally representative study. J Am Acad Child Adolesc Psychiatry 48:35–41

    Article  PubMed  Google Scholar 

  • Shulman ST (2009) Pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS): update. Curr Opin Pediatr 21:127–130

    Article  PubMed  Google Scholar 

  • Simon V, Czobor P, Bálint S, Mészáros A, Bitter I (2009) Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry 194:204–211

    Article  PubMed  Google Scholar 

  • Singh MK, DelBello MP, Kowatch RA, Strakowski SM (2006) Co-occurrence of bipolar and attention-deficit hyperactivity disorders in children. Bipolar Disord 8:710–720

    Article  PubMed  Google Scholar 

  • Smalley SL, Kustanovich V, Minassian SL, Stone JL, Ogdie MN, McGough JJ, McCracken JT, MacPhie IL, Francks C, Fisher SE, Cantor RM, Monaco AP, Nelson SF (2002) Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. Am J Hum Genet 71:959–963

    Article  PubMed  Google Scholar 

  • Smart D, Sanson A, Prior M (1996) Connections between reading disability and behaviour problems: testing temporal and causal hypotheses. J Abnorm Child Psychol 24:363–383

    Article  CAS  PubMed  Google Scholar 

  • Smoller JW, Tsuang MT (1998) Panic and phobic anxiety: defining phenotypes for genetic studies. Am J Psychiatry 155:1152–1162

    Google Scholar 

  • Snider LA, Swedo SE (2004) PANDAS: current status and directions for research. Mol Psychiatry 9:900–907

    Article  CAS  PubMed  Google Scholar 

  • Souza I, Pinheiro MA, Mattos P (2005) Anxiety disorders in an attention-deficit/hyperactivity disorder clinical sample. Arq Neuropsiquiatr 63:407–409

    PubMed  Google Scholar 

  • Spencer T, Biederman J, Harding M, Wilens T, Faraone S (1995) The relationship between tic disorders and Tourette’s syndrome revisited. J Am Acad Child Adolesc Psychiatry 34:1133–1139

    Article  CAS  PubMed  Google Scholar 

  • Spencer T, Biederman J, Harding M, O’Donnell D, Wilens T, Faraone S, Coffey B, Geller D (1998) Disentangling the overlap between Tourette’s disorder and ADHD. J Child Psychol Psychiatry 7:1037–1044

    Article  Google Scholar 

  • Spencer T, Biederman M, Coffey B, Geller D, Wilens T, Faraone S (1999) The 4–year course of tic disorders in boys with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:842–847

    Article  CAS  PubMed  Google Scholar 

  • Spencer TJ, Biederman J, Faraone S, Mick E, Coffey B, Geller D, Kagan J, Bearman SK, Wilens T (2001) Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD. Am J Psychiatry 158:611–617

    Article  CAS  PubMed  Google Scholar 

  • Steinhausen HC, Novik TS, Baldursson G, Curatolo P, Lorenzo MJ, Rodrigues Pereira R, Ralston SJ, ADORE RothenbergerA, Group Study (2006) Co-existing psychiatric problems in ADHD in the ADORE cohort. Eur Child Adolesc Psychiatry 15:i25–i29

    Article  PubMed  Google Scholar 

  • Sullivan MA, Rudnik-Levin F (2001) Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. Ann N Y Acad Sci 931:251–270

    Article  CAS  PubMed  Google Scholar 

  • Surman C, Adamson J, Petty C, Biederman J, Kenealy D, Levine M, Mick E, Faraone S (2009) Association between attention-deficit/hyperactivity disorder and sleep impairment in adulthood: evidence from a large controlled study. J Clin Psychiatry 70:1523–1529

    Article  PubMed  Google Scholar 

  • Swanson JM, Elliott GR, Greenhill LL, Wigal T, Arnold LE, Vitiello B, Hechtman L, Epstein JN, Pelham WE, Abikoff HB, Newcorn JH, Molina BSG, Hinshaw SP, Wells KC, Hoza B, Jensen PS, Gibbons RD, Hur K, Stehli A, Davies M, March JS, Conners CK, Caron M, Volkow ND (2007) Effects of stimulant medication on growth rates across 3 years in the MTA follow-up. J Am Acad Child Adolesc Psychiatry 46:1015–1027

    Article  PubMed  Google Scholar 

  • Tamam L, Tuglu C, Karatas G (2006) Adult attention-deficit/hyperactivity disorder in patients with bipolar I disorder in remission: preliminary study. Psychiatry Clin Neurosci 60:480–485

    Article  PubMed  Google Scholar 

  • Thapar A, Harrington R, McGuffin P (2001) Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. Br J Psychiatry 179:224–229

    Article  CAS  PubMed  Google Scholar 

  • Thunström M (2002) Severe sleep problems in infancy associated with subsequent development of attention-deficit/hyperactivity disorder at 5.5 years of age. Acta Paediatr 91:584–592

    Article  PubMed  Google Scholar 

  • Tillman R, Geller B, Craney JL, Bolhofner K, Williams M, Zimerman B, Frazier J, Beringer L (2003) Temperament and character factors in a prepubertal and early adolescent bipolar disorder phenotype compared to attention deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 13:531–543

    Article  PubMed  Google Scholar 

  • Todd RD, Rasmussen ER, Neuman RJ, Reich W, Hudziak JJ, Bucholz KK, Madden PA, Heath A (2001) Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins. Am J Psychiatry 158:1891–1898

    Article  CAS  PubMed  Google Scholar 

  • Van Ameringen M, Mancini C, Simpson W, Patterson B (2010) Adult Attention Deficit Hyperactivity Disorder in an Anxiety Disorders Population. CNS Neurosci Ther Apr 8 [Epub ahead of print]

  • Vance A, Harris K, Boots M, Talbot J, Karamitsios M (2003) Which anxiety disorders may differentiate attention deficit hyperactivity disorder, combined type with dysthymic disorder from attention deficit hyperactivity disorder, combined type alone? Aust N Z J Psychiatry 37:563–569

    Article  PubMed  Google Scholar 

  • Vermeiren R, De Clippele A, Deboutte D (2000) A descriptive survey of Flemish delinquent adolescents. J Adolesc 23:277–285

    Article  CAS  PubMed  Google Scholar 

  • Vloet TD, Konrad K, Herpertz SC, Matthias K, Polier GG, Herpertz-Dahlmann B (2010) Development of antisocial disorders–impact of the autonomic stress system]. Fortschr Neurol Psychiatr 78:131-138

    Google Scholar 

  • Volk HE, Todd RD (2007) Does the Child Behavior Checklist juvenile bipolar disorder phenotype identify bipolar disorder? Biol Psychiatry 62:115–120

    Article  PubMed  Google Scholar 

  • von Gontard A, Heron J, Joinson C (2010) Factors associated with low and high voiding frequency in children with diurnal urinary incontinence. BJU Int 105:396–401

    Article  Google Scholar 

  • Walitza S, Zellmann H, Irblich B, Lange KW, Tucha O, Hemminger U, Wucherer K, Rost V, Reinecker H, Wewetzer C, Warnke A (2008) Children and adolescents with obsessive-compulsive disorder and comorbid attention-deficit/hyperactivity disorder: preliminary results of a prospective follow-up study. J Neural Transm 115:187–190

    Article  CAS  PubMed  Google Scholar 

  • Walshaw PD, Alloy LB, Sabb FW (2010) Executive function in pediatric bipolar disorder and attention-deficit hyperactivity disorder: in search of distinct phenotypic profiles. Neuropsychol Rev 20:103–120

    Article  PubMed  Google Scholar 

  • Warnke A (1999) Reading and spelling disorders: clinical features and causes. Eur Child Adolesc Psychiatry 8:2–12

    Article  PubMed  Google Scholar 

  • Weiss G, Hechtman L, Milroy T, Perlman T (1885) Psychiatric status of hyperactives as adults: a controlled prospective 15-year follow-up of 63 hyperactive children. J Am Acad Child Psychiatry 24:211–220

    Google Scholar 

  • West AE, Schenkel LS, Pavuluri MN (2008) Early childhood temperament in pediatric bipolar disorder and attention deficit hyperactivity disorder. J Clin Psychol 64:402–421

    Article  PubMed  Google Scholar 

  • Wilens TE, Spencer T, Biederman J, Wozianek J (1995) Combined pharmacotherapy: an emerging trend in paediatric psychopharmacology. J Am Acad Child Adolesc Psychiatry 34:110–112

    Article  CAS  PubMed  Google Scholar 

  • Wilens TE, Biederman J, Brown S, Tanguay S, Monuteaux MC, Blake C, Spencer TJ (2002) Psychiatric comorbidity and functioning in clinically referred preschool children and schoolage youths with ADHD. J Am Acad Child Adolesc Psychiatry 41:262–268

    Article  PubMed  Google Scholar 

  • Wilens TE, Faraone SV, Biederman J, Gunawardene S (2003) Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics 111:179–185

    Article  PubMed  Google Scholar 

  • Willcutt EG, Pennington BF (2000) Comorbidity of reading disability and attention-deficit/hyperactivity disorder: differences by gender and subtype. J Learn Disabil 33:179–191

    Article  CAS  PubMed  Google Scholar 

  • Willcutt EG, Pennington BF, Boada R et al (2001) A comparison of the cognitive deficits in reading disability and attentiondeficit/hyperactivity disorder. J Abnorm Psychol 110:157–172

    Article  CAS  PubMed  Google Scholar 

  • Willcutt EG, Pennington BF, Olson RK, DeFries JC (2007) Understanding comorbidity: a twin study of reading disability and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 144B:709–714

    Article  PubMed  Google Scholar 

  • Wingo AP, Ghaemi SN (2007) A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder. J Clin Psychiatry 68:1776–1784 (review)

    Google Scholar 

  • Wozniak J, Biederman J, Mundy E, Mennin D, Faraone SV (1995) A pilot family study of childhood-onset mania. J Am Acad Child Adolesc Psychiatry 34:1577–1583

    Article  CAS  PubMed  Google Scholar 

  • Yerys BE, Wallace GL, Sokoloff JL, Shook DA, James JD, Kenworthy L (2009) Attention deficit/hyperactivity disorder symptoms moderate cognition and behaviour in children with autism spectrum disorders. Autism Res 2:322–333

    PubMed  Google Scholar 

  • Yordanova J, Dumais-Huber C, Rothenberger A, Woerner W (1997) Frontocortical activity in children with comorbidity of tic disorder and attention-deficit hyperactivity disorder. Biol Psychiatry 41:585–594

    Article  CAS  PubMed  Google Scholar 

  • Yordanova J, Heinrich H, Kolev V, Rothenberger A (2006) Increased event-related theta activity as a psychophysiological marker of comorbidity in children with tics and attention-deficit/hyperactivity disorders. Neuroimage 32:940–955

    Article  PubMed  Google Scholar 

  • Zepf FD (2009) Attention deficit-hyperactivity disorder and early-onset bipolar disorder: two facets of one entity? Dialogues Clin Neurosci 11:63–72

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstr. 15, 97080, Würzburg, Germany

    Regina Taurines, Tobias Renner, Andreas Warnke & Marcel Romanos

  2. Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, 01307, Dresden, Germany

    Jochen Schmitt

  3. Warwick Medical School, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK

    Alex Curtis Conner

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  1. Regina Taurines
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Taurines, R., Schmitt, J., Renner, T. et al. Developmental comorbidity in attention-deficit/hyperactivity disorder. ADHD Atten Def Hyp Disord 2, 267–289 (2010). https://doi.org/10.1007/s12402-010-0040-0

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