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Noroviruses: State of the Art

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Abstract

Noroviruses are a common cause of both endemic and epidemic gastroenteritis. These highly infectious viruses usually cause self-limited disease, but chronic infections occur in highly immunocompromised patients and unusual manifestations are also being described in some populations. Histoblood-group antigen expression is now recognized as an important susceptibility factor for many norovirus strains, but a correlate of acquired immunity to infection or illness has not yet been identified. Currently, treatment and prevention strategies rely on non-specific measures. However, virus-like particles containing capsid antigens are undergoing evaluation as a vaccine candidate for illness prevention. This article reviews the biologic properties, epidemiology, clinical features, host susceptibility, diagnosis, and treatment and prevention of norovirus infection.

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Acknowledgements

This work was performed with support from the National Institutes of Health (N01-AI-25465, P01-AI-057788, M01-RR-00188, P30-DK-56338, and U54-AI-057156). The contents are solely the responsibility of the author and do not necessarily represent the official views of the NIH.

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  1. Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, MS BCM 280, Houston, TX, 77030, USA

    Robert L. Atmar

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Atmar, R.L. Noroviruses: State of the Art. Food Environ Virol 2, 117–126 (2010). https://doi.org/10.1007/s12560-010-9038-1

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