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ADHD and nutritional supplements

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Current Attention Disorders Reports

Abstract

Many children with attention-deficit/hyperactivity disorder (ADHD) use nutritional therapies (supplements and elimination diets) as a treatment strategy. This article reviews the use of supplements in ADHD. Several nutrients have known roles in the support of brain function. Nutrient sufficiency during brain development is critical. Because 1) data indicate that many American schoolchildren do not meet nutritional recommendations, 2) the prefrontal cortex continues to develop into young adulthood, and 3) ADHD symptoms are thought to arise from inefficient functioning of the prefrontal cortex and its connections, the role of nutritional supplements in childhood ADHD is important to consider.

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References and Recommended Reading

  1. Bryan J, Osendarp S, Hughes D, et al.: Nutrients for cognitive development in school-aged children. Nutr Rev 2004, 62:295–306.

    Article  PubMed  Google Scholar 

  2. Munoz KA, Krebs-Smith SM, Ballard-Barbash R, et al.: Food intakes of US children and adolescents compared with recommendations. Pediatrics 1997, 100:323–329.

    Article  PubMed  CAS  Google Scholar 

  3. Kaplan BJ, McNicol J, Conte RA, et al.: Overall nutrient intake of preschool hyperactive and normal boys. J Abnorm Child Psychol 1989, 17:127–132.

    Article  PubMed  CAS  Google Scholar 

  4. Wolraich ML, Lindgren SD, Stumbo PJ, et al.: Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children. N Engl J Med 1994, 330:301–307.

    Article  PubMed  CAS  Google Scholar 

  5. Wolraich ML, Wilson DB, White JW: The effect of sugar on behavior or cognition in children. A meta-analysis. JAMA 1995, 274:1617–1621.

    Article  PubMed  CAS  Google Scholar 

  6. Fischer K, Colombani PC, Langhans W, et al.: Carbohydrate to protein ratio in food and cognitive performance in the morning. Physiol Behav 2002, 75:411–423.

    Article  PubMed  CAS  Google Scholar 

  7. Nabb S, Benton D: The influence on cognition of the interaction between the macro-nutrient content of breakfast and glucose tolerance. Physiol Behav 2006, 87:16–23.

    Article  PubMed  CAS  Google Scholar 

  8. Conners CK: Feeding the Brain: How Foods Affect Children. Reading, MA: Perseus Books; 1989.

    Google Scholar 

  9. Girardi NL, Shaywitz SE, Shaywitz BA, et al.: Blunted catecholamine response after glucose ingestion in children with attention deficit disorder. Pediatr Res 1995, 38:539–542.

    Article  PubMed  CAS  Google Scholar 

  10. Arnold LE: Alternative treatments for adults with attention-deficit hyperactivity disorder (ADHD). Ann N Y Acad Sci 2001, 931:310–341.

    Article  PubMed  CAS  Google Scholar 

  11. McCann JC, Ames BN: An overview of evidence for a causal relationship between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr 2007, 85:931–945.

    PubMed  CAS  Google Scholar 

  12. McCann JC, Hudes M, Ames BN: An overview of evidence for a causal relationship between direct availability of choline during development and cognitive function in offspring. Neurosci Biobehav Rev 2006, 30:696–712.

    Article  PubMed  CAS  Google Scholar 

  13. McCann JC, Ames BN: Is docosahexanoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005, 82:281–295.

    PubMed  CAS  Google Scholar 

  14. Benton D: Micro-nutrient supplementation and the intelligence of children. Neurosci Biobehav Rev 2001, 25:297–309.

    Article  PubMed  CAS  Google Scholar 

  15. Schoenthaler SJ, Bier ID, Young K, et al.: The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren: a randomized, double-blind placebo-controlled trial. J Altern Compliment Med 2000, 6:19–29.

    Article  CAS  Google Scholar 

  16. Osendarp SJ, Baghurst KI, Bryan J, et al.: Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. Am J Clin Nutr 2007, 86:1082–1093.

    PubMed  CAS  Google Scholar 

  17. Schoenthaler SJ, Moody JM, Pankow LD: Applied nutrition and behavior. J Appl Nutr 1991, 43:31–39.

    Google Scholar 

  18. Schoenthaler SJ, Amos SP, Doraz WE, et al.: Controlled trial of vitamin-mineral supplementation on violent and non-violent antisocial behavior among incarcerated juveniles. J Nutr Environ Med 1997, 7:343–352.

    Article  Google Scholar 

  19. Gesch CB, Hammond SM, Hampson SE, et al.: Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behavior of young adult prisoners. Br J Psychaitry 2002, 181:22–28.

    Article  Google Scholar 

  20. Starobrat-Hermelin B, Kozielec T: The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 1997, 10:149–156.

    PubMed  CAS  Google Scholar 

  21. Toren P, Eldar S, Sela BA, et al.: Zinc deficiency in attention-deficit hyperactivity disorder. Biol Psychiatry 1996, 40:1308–1310.

    Article  PubMed  CAS  Google Scholar 

  22. Arnold LE, DiSilvestro RA: Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2005, 15:619–627.

    Article  PubMed  Google Scholar 

  23. Arnold LE, Bozzolo H, Holloway J, et al.: Serum zinc correlates with parent- and teacher-rated inattention in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2005, 15:628–636.

    Article  PubMed  Google Scholar 

  24. Weber W, Newmark S: Complementary and alternative medical therapies for attention-deficit/hyperactivity disorder and autism. Pediatr Clin North Am 2007, 54:983–1006.

    Article  PubMed  Google Scholar 

  25. Akhondzadeh S, Mohammadi MR, Khademi M: Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry 2004, 4:9–14.

    Article  PubMed  Google Scholar 

  26. Nogovitsina OR, Levitina EV: Neurological aspect of clinical symptoms, pathophysiology and correction in attention deficit hyperactivity disorder [in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova 2006, 106:17–20.

    PubMed  CAS  Google Scholar 

  27. Mousain-Bosc M, Roche M, Polge A, et al.: Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnes Res 2006, 19:46–52.

    PubMed  CAS  Google Scholar 

  28. Konofal E, Lecendreux M, Arnulf, I, et al.: Iron deficiency in children with attention deficit hyperactivity disorder. Arch Pediatr Adolesc Med 2004, 158:1113–1115.

    Article  PubMed  Google Scholar 

  29. Harding KL, Judah RD, Gant C: Outcome-based comparison of Ritalin versus food-supplement treated children with AD/HD. Altern Med Rev 2003, 8:319–330.

    PubMed  Google Scholar 

  30. Gadoth N: On fish oil and omega-3 supplementation in children: the role of such supplementation on attention and cognitive dysfunction. Brain Dev 2008, 30:309–312.

    Article  PubMed  Google Scholar 

  31. Hallahan B, Garland MR: Essential fatty acids and their role in the treatment of impulsivity disorders. Prostaglandins Leukot Essent Fatty Acids 2004, 71:211–216.

    Article  PubMed  CAS  Google Scholar 

  32. Tassoni D, Kaur G, Weisinger RS, et al.: The role of eicosanoids in the brain. Asia Pac J Clin Nutr 2008, 17:220–228.

    PubMed  CAS  Google Scholar 

  33. Antalis CJ, Stevens LJ, Campbell M, et al.: Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2006, 75:299–308.

    Article  PubMed  CAS  Google Scholar 

  34. Colter AL, Cutler C, Meckling KA: Fatty acid status and behavioral symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008, 7:8–18.

    Article  PubMed  CAS  Google Scholar 

  35. Burgess JR, Stevens L, Zhang W, et al.: Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am J Clin Nutr 2000, 71S:327S–330S.

    Google Scholar 

  36. Stevens LJ, Zentall SS, Abate ML, et al.: Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav 1996, 59:915–920.

    Article  PubMed  CAS  Google Scholar 

  37. Arnold LE, Kleykamp D, Votolano NA, et al.: Gammalinolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine. Biol Psychiatry 1989, 25:222–228.

    Article  PubMed  CAS  Google Scholar 

  38. Voigt RG, Llorente AM, Jensen CL, et al.: A randomized, double-blind, placebo-controlled trial of docosahexanoic acid supplementation in children with attention-deficit/ hyperactivity disorder. J Pediatr 2001, 139:189–196.

    Article  PubMed  CAS  Google Scholar 

  39. Richardson AJ, Montgomery P: The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005, 115:1360–1366.

    Article  PubMed  Google Scholar 

  40. Richardson AJ, Puri BK: A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry 2002, 26:233–239.

    Article  PubMed  CAS  Google Scholar 

  41. Sinn N, Bryan J: Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD. J Dev Behav Pediatr 2007, 28:82–91.

    Article  PubMed  Google Scholar 

  42. Stevens LJ, Zhang W, Peck L, et al.: EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 2003, 38:1007–1021.

    Article  PubMed  CAS  Google Scholar 

  43. Colombo J, Kannass KN, Shaddy DJ, et al.: Maternal DHA and the development of attention in infancy and toddler-hood. Child Dev 2004, 75:1254–1267.

    Article  PubMed  Google Scholar 

  44. Torrioloa MG, Vernacotola S, Peruzzi L, et al.: A doubleblind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Am J Med Genetics A 2008, 146A:803–812.

    Article  Google Scholar 

  45. Van Oudheusden LJ, Scholte HR: Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2002, 67:33–38.

    Article  PubMed  Google Scholar 

  46. Arnold LE, Amato A, Bozzolo H, et al.: Acetyl-L-carnitine in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial. J Child Adolesc Psychopharmacol 2007, 17:791–802.

    Article  PubMed  Google Scholar 

  47. Trebaticka J, Kopasova S, Hradecna Z, et al.: Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur Child Adolesc Psychiatry 2006, 15:329–335.

    Article  PubMed  Google Scholar 

  48. Chovanova Z, Muchova J, Sivonova M, et al.: Effect of polyphenolic extract, pycnogenol, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder. Free Radic Res 2006, 40:1003–1010.

    Article  PubMed  CAS  Google Scholar 

  49. Dvorakova M, Jezova D, Blazicek P, et al.: Urinary catecholamines in children with attention deficit hyperactivity disorder (ADHD): modulation by a polyphenolic extract from pine bark (pycnogenolR). Nutr Neurosci 2007, 10:151–157.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Marianne M. Glanzman.

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Glanzman, M.M. ADHD and nutritional supplements. Curr Atten Disord Rep 1, 75–81 (2009). https://doi.org/10.1007/s12618-009-0011-6

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  • DOI: https://doi.org/10.1007/s12618-009-0011-6

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