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Glioblastomas with oligodendroglial component-common origin of the different histological parts and genetic subclassification

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An Erratum to this article was published on 01 June 2011

Abstract

Background

Glioblastomas are the most common and most malignant brain tumors in adults. A small subgroup of glioblastomas contains areas with histological features of oligodendroglial differentiation (GBMO). Our objective was to genetically characterize the oligodendroglial and the astrocytic parts of GBMOs and correlate morphologic and genetic features with clinical data.

Methods

The oligodendroglial and the “classic” glioblastoma parts of 13 GBMO were analyzed separately by interphase fluoreszence in situ hybridization (FISH) on paraffin sections using a custom probe set (regions 1p, 1q, 7q, 10q, 17p, 19q, cen18, 21q) and by comparative genomic hybridization (CGH) of microdissected paraffin embedded tumor tissue.

Results

We identified four distinct genetic subtypes in 13 GBMOs: an “astrocytic” subtype (9/13) characterized by +7/-10; an “oligodendroglial” subtype with -1p/-19q (1/13); an “intermediate” subtype showing +7/-1p (1/13), and an “other” subtype having none of the former aberrations typical for gliomas (2/13). The different histological tumor parts of GBMO revealed common genetic changes in all tumors and showed additional aberrations specific for each part.

Conclusion

Our findings demonstrate the monoclonal origin of GBMO followed by the development of the astrocytic and oligodendroglial components. The diagnostic determination of the genetic signatures may allow for a better prognostication of the patients.

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Acknowledgement

This work was supported by a research grant from the Interdisziplinäres Zentrum für Klinische Forschung (IZKF) at the Medizinische Fakultät der Friedrich-Schiller-Universität Jena, Germany.

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Author notes

  1. Martin Klink

    Present address: Deutscher Wetterdienst, 14473, Potsdam, Germany

  2. Karen Stout-Weider

    Present address: Charité-Universitätsmedizin Berlin, Institut für Medizinische Genetik, Augustenburger Platz 1, 13353, Berlin, Germany

Authors and Affiliations

  1. Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany

    Barbara Klink, Ben Schlingelhof, Martin Klink, Karen Stout-Weider & Evelin Schrock

  2. Institut für Pathologie, Medizinische Fakultät, Friedrich-Schiller Universität Jena, Ziegelmühlenweg 1, 07743, Jena, Germany

    Stephan Patt

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Correspondence to Barbara Klink.

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This paper is a reprint from ‘Glioblastomas with oligodendroglial component-common origin of the different histological parts and genetic subclassification, Barbara Klink, Ben Schlingelhof, Martin Klink, Karen Stout-Weider, Stephan Patt, Evelin Schrock’ originally published in Analytical Cellular Pathology/Cellular Oncology, Volume 33, number 1, 2010, pp. 37–54, IOS Press.

An erratum to this article can be found at http://dx.doi.org/10.1007/s13402-011-0055-3

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Klink, B., Schlingelhof, B., Klink, M. et al. Glioblastomas with oligodendroglial component-common origin of the different histological parts and genetic subclassification. Cell Oncol. 34, 261–275 (2011). https://doi.org/10.1007/s13402-011-0034-8

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