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The Contribution of the Neural Crest to the Vertebrate Body

  • Chapter
Book cover Neural Crest Induction and Differentiation

Part of the book series: Advances in Experimental Medicine and Biology ((volume 589))

Abstract

As a transitory structure providing adult tissues of the vertebrates with very diverse cell types, the neural crest (NC) has attracted for long the interest of developmental biologists and is still the subject of ongoing research in a variety of animal models. Here we review a number of data from in vivo cell tracing and in vitro single cell culture experiments, which gained new insights on the mechanisms of cell migration, proliferation and differentiation during NC ontogeny. We put emphasis on the role of Hox genes, morphogens and interactions with neighbouring tissues in specifying and patterning the skeletogenic NC cells in the head. We also include advances made towards characterizing multipotent stem cells in the early NC as well as in various NC derivatives in embryos and even in adult.

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Authors and Affiliations

  1. Laboratoire d’Embryologie Cellulaire et Moléculaire, CNRS UMR 7128, 49 bis, avenue de la Belle Gabrielle, 94736, Nogent-sur-Marne Cedex, France

    Elisabeth Dupin, Sophie Creuzet & Nicole M. Le Douarin

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  1. Elisabeth Dupin
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  2. Sophie Creuzet
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  3. Nicole M. Le Douarin
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Correspondence to Nicole M. Le Douarin .

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  1. Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Jean-Pierre Saint-Jeannet Ph.D.

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Dupin, E., Creuzet, S., Le Douarin, N.M. (2006). The Contribution of the Neural Crest to the Vertebrate Body. In: Saint-Jeannet, JP. (eds) Neural Crest Induction and Differentiation. Advances in Experimental Medicine and Biology, vol 589. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-46954-6_6

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