Abstract
Proteoglycans mediate diverse cellular processes by interacting with a variety of protein ligands. Some of these interactions depend on the proteoglycan core protein, but most involve electrostatic interactions with the glycosaminoglycan chains attached to the core protein (Jackson et al., 1991; Kjellén and Lindahl, 1991; Esko, 1991). These latter interactions depend on the composition and arrangement of monosaccharide residues in the chains, which in turn depend on the glycosyltransferases, sulfotransferases, and epimerases that catalyze chain polymerization and modification. Thus, the biological activity of proteoglycans is intimately related to the regulation of glycosaminoglycan biosynthesis.
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© 1992 Springer Science+Business Media New York
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Esko, J.D. (1992). Animal Cell Mutants Defective in Heparan Sulfate Polymerization. In: Lane, D.A., Björk, I., Lindahl, U. (eds) Heparin and Related Polysaccharides. Advances in Experimental Medicine and Biology, vol 313. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2444-5_10
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DOI: https://doi.org/10.1007/978-1-4899-2444-5_10
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