Skip to main content

Asymmetric Stem Cell Division in Development and Cancer

  • Chapter
Asymmetric Cell Division

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 45))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akong K, McCartney BM, Peifer M (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev Biol 250:71–90.

    Article  PubMed  CAS  Google Scholar 

  • Albertson R, Doe CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 5:166–170.

    Article  PubMed  CAS  Google Scholar 

  • Al-Hajj M, Clarke MF (2004) Self-renewal and solid tumor stem cells. Oncogene 23:7274–7282.

    Article  PubMed  CAS  Google Scholar 

  • Arama E, Dickman D, Kinchie Z, Shearn A, Lev Z (2000) Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain. Oncogene 19:3706–3716.

    Article  PubMed  CAS  Google Scholar 

  • Bello BC, Hirth F, Gould AP (2003) A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis. Neuron 37:209–219.

    Article  PubMed  CAS  Google Scholar 

  • Bello B, Reichert H, Hirth F (2006) The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development 133:2639–2648.

    Article  PubMed  CAS  Google Scholar 

  • Betschinger J, Mechtler K, Knoblich JA (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124:1241–1253.

    Article  PubMed  CAS  Google Scholar 

  • Bossing T, Udolph G, Doe CQ, Technau GM (1996) The embryonic central nervous system lineages of Drosophila melanogaster. I. Neuroblast lineages derived from the ventral half of the neuroectoderm. Dev Biol 179:41–64.

    Article  PubMed  CAS  Google Scholar 

  • Brumby AM, Richardson HE (2003) scribble mutants cooperate with oncogenic RAs or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22:5769–5779.

    Article  PubMed  CAS  Google Scholar 

  • Brumby AM, Richardson HE (2005) Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer 5:626–639.

    Article  PubMed  CAS  Google Scholar 

  • Campos-Ortega JA, Hartenstein V (1997) The embryonic development of Drosophila melanogaster. Springer, Berlin Heidelberg New York.

    Google Scholar 

  • Caussinus E, Gonzalez C (2005) Induction of tumour growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37:1125–1129.

    Article  PubMed  CAS  Google Scholar 

  • Ceron J, Gonzalez C, Tejedor FJ (2001) Patterns of cell division and expression of asymmetric cell fate determinants in postembryonic neuroblast lineages of Drosophila. Dev Biol 230:125–138.

    Article  PubMed  CAS  Google Scholar 

  • Chia W, Yang X (2002) Asymmetric division of Drosophila neural progenitors. Curr Opin Genet Dev 12:459–464.

    Article  PubMed  CAS  Google Scholar 

  • Clarke MF, Fuller M (2006) Stem cells and cancer: two faces of eve. Cell 124:1111–1115.

    Article  PubMed  CAS  Google Scholar 

  • Eckfeldt CE, Mendenhall EM, Verfaillie CM (2005) The molecular repertoire of the ‘almighty’ stem cell. Nat Rev Mol Cell Bio 6:726–737.

    Article  CAS  Google Scholar 

  • Fomchenko EI, Holland EC (2005) Stem cells and brain cancer. Exp Cell Res 306:323–329.

    Article  PubMed  CAS  Google Scholar 

  • Fortini ME, Skupski MP, Boguski MS, Hariharan IK (2000) A survey of human disease gene counterparts in the Drosophila genome. J Cell Biol 150:F23–F30.

    Article  PubMed  CAS  Google Scholar 

  • Frank DJ, Edgar BA, Roth MB (2002) The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis. Development 129:399–407.

    PubMed  CAS  Google Scholar 

  • Fuse N, Hisata K, Katzen AL, Matsuzaki F (2003) Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions. Curr Biol 13:947–954.

    Article  PubMed  CAS  Google Scholar 

  • Gateff E (1978a) Malignant neoplasm of genetic origin in Drosophila melanogaster. Science 200:1449–1459.

    Article  Google Scholar 

  • Gateff E (1978b) The genetics and epigenetics of neoplasm in Drosophila. Biol Rev Camb Philos Soc 53:123–168.

    Article  PubMed  CAS  Google Scholar 

  • Gateff E, Schneidermann HA (1967) Developmental studies of a new mutant of Drosophila melanogaster lethal malignant brain tumor l(2) gl4. Am Zool 7:760.

    Google Scholar 

  • Gateff E, Loffler T, Wismar J (1993) A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene. Mech Dev 41:15–31.

    Article  PubMed  CAS  Google Scholar 

  • Grewal SS, Li L, Orian A, Eisenmann RN, Edgar BA (2005) Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat Cell Biol 7:295–302.

    Article  PubMed  CAS  Google Scholar 

  • Hahn WC, Weinberg RA (2002) Rules for making human tumor cells. N Engl J Med 347:1593–1603.

    Article  PubMed  CAS  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70.

    Article  PubMed  CAS  Google Scholar 

  • Harris H (2005) A long view of fashions in cancer research. BioEssays 27:833–838.

    Article  PubMed  Google Scholar 

  • Hawkins N, Garriga G (1998) Asymmetric cell division: from A to Z. Genes Dev 12:3625–3638.

    Article  PubMed  CAS  Google Scholar 

  • Humbert P, Russell S, Richardson H (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. BioEssays 25:542–553.

    Article  PubMed  CAS  Google Scholar 

  • Huttner WB, Kosodo Y (2005) Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. Curr Opin Cell Biol 17:648–657.

    Article  PubMed  CAS  Google Scholar 

  • Ito K, Hotta Y (1992) Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogaster. Dev Biol 149:134–148.

    Article  PubMed  CAS  Google Scholar 

  • Klezovitch O, Fernandez TE, Tapscott SJ, Vasioukhin V (2004) Loss of cell polarity causes severe brain dysplasia in lgl1 knockout mice. Genes Dev 18:559–571.

    Article  PubMed  CAS  Google Scholar 

  • Knoblich JA (2001) Asymmetric cell division during animal development. Nat Rev Mol Cell Biol 2:11–20.

    Article  PubMed  CAS  Google Scholar 

  • Lee T, Luo L (2001) Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci 24:251–254.

    Article  PubMed  CAS  Google Scholar 

  • Lee C-Y, Robinson KJ, Doe CQ (2006a) Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439:594–598.

    Article  PubMed  CAS  Google Scholar 

  • Lee CY, Wilkinson BD, Siegrist SE, Wharton RP, Doe CQ (2006b) Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev Cell 10:441–449.

    Article  PubMed  CAS  Google Scholar 

  • Lechler T, Fuchs E (2005) Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 437:275–280.

    Article  PubMed  Google Scholar 

  • Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN (2003) Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40:1105–1118.

    Article  PubMed  CAS  Google Scholar 

  • Li L, Vaessin H (2000) Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev 14:147–151.

    PubMed  CAS  Google Scholar 

  • Li L, Xie T (2005) Stem cell niche: structure and function. Annu Rev Cell Dev Biol. 21:605–631.

    Article  PubMed  CAS  Google Scholar 

  • Loop T, Leemans R, Stiefel U, Hermida L, Egger B, Xie F, Primig M, Certa U, Fischbach KF, Reichert H, Hirth F (2004) Transcriptional signature of an adult brain tumour in Drosophila. BMC Genomics 5:24.

    Article  PubMed  Google Scholar 

  • Marignani PA (2005) LKB1, the multitasking tumour suppressor kinase. J Clin Pathol 58:15–19.

    Article  PubMed  CAS  Google Scholar 

  • Maurange C, Gould AP (2005) Brainy but not too brainy: starting and stopping neuroblast divisions in Drosophila. Trends Neurosci 28:30–36.

    Article  PubMed  CAS  Google Scholar 

  • Mechler BM, McGinnis W, Gehring WJ (1985) Molecular cloning of lethal (2) giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J 4:1551–1557.

    PubMed  CAS  Google Scholar 

  • Pagliarini RA, Xu T (2003) A genetic screen in Drosophila for metastatic behaviour. Science 302:1227–1231.

    Article  PubMed  CAS  Google Scholar 

  • Pardal R, Clarke MF, Morrison SJ (2003) Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3:895–902.

    Article  PubMed  CAS  Google Scholar 

  • Peterson C, Carney GE, Taylor BJ, White K (2002) Reaper is required for neuroblast apoptosis during Drosophila development. Development 129:1467–1476.

    PubMed  CAS  Google Scholar 

  • Potter CJ, Turenchalk GS, Xu T (2000) Drosophila in cancer research; an expanding role. Trends Genet 16:33–39.

    Article  PubMed  CAS  Google Scholar 

  • Prokopenko SN, Chia W (2005) When timing is everything: role of cell cycle regulation in asymmetric division. Semin Cell Dev Biol 16:423–437.

    Article  PubMed  CAS  Google Scholar 

  • Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105–111.

    Article  PubMed  CAS  Google Scholar 

  • Rolls MM, Albertson R, Shih HP, Lee CY, Doe CQ (2003) Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol 163:1089–1098.

    Article  PubMed  CAS  Google Scholar 

  • Skeath JB, Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13:8–15.

    Article  PubMed  CAS  Google Scholar 

  • Sonoda J, Wharton RP (2001) Drosophila brain tumour is a translational repressor. Genes Dev 15:762–773.

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Chia W (2005) Drosophila neural progenitor polarity and asymmetric division. Biol Cell 97:63–74.

    Article  PubMed  CAS  Google Scholar 

  • Watson KL, Justice RW, Bryant PJ (1994) Drosophila in cancer research: the first fifty tumor suppressor genes. J Cell Sci Suppl 18:19–33.

    PubMed  CAS  Google Scholar 

  • Wodarz A, Huttner WB (2003) Asymmetric cell division during neurogenesis of Drosophila and vertebrates. Mech Dev 120:1297–1309.

    Article  PubMed  CAS  Google Scholar 

  • Woodhouse E, Hersperger E, Stetler-Stevenson WG, Liotta LA, Shearn A (1994) Increased type IV collagenase in Lgl-induced invasive tumors of Drosophila. Cell Growth Differ 5:151–159.

    PubMed  CAS  Google Scholar 

  • Woodhouse E, Hersperger E, Shearn A (1998) Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev Genes Evol 207:542–550.

    Article  PubMed  CAS  Google Scholar 

  • Woodhouse EC, Fisher A, Bandle RW et al. (2003) Drosophila screening model for metastasis: Semaphorin 5c is required for L(2) gl cancer phenotype. Proc Natl Acad Sci USA 100:11463–11468.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Caussinus, E., Hirth, F. (2007). Asymmetric Stem Cell Division in Development and Cancer. In: Macieira-Coelho, A. (eds) Asymmetric Cell Division. Progress in Molecular and Subcellular Biology, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69161-7_9

Download citation

Publish with us

Policies and ethics