The rise in the incidence and mortality from melanoma of the skin is slowing down in younger age groups in the United States. In many White populations, including that of the US, melanoma incidence and mortality rates increase according to proximity of residence to the Equator. Variations with age in this gradient do not seem to have been examined. We examined how the influence of latitude on melanoma rates varied with age. Estimates of age-specific trends by time and by latitude for natural logarithm (Ln) melanoma incidence-rates from the Surveillance, Epidemiology and End Results (SEER) programs, and Ln melanoma mortality rates from the US Vital Statistics were derived from fitted regression equations. Unexpectedly, a decline from old age to youth in the influence of latitude was found for both incidence and mortality from melanoma of the skin in males, and for mortality in females. Further, these changes in the relationship to latitude with age correlated with the changes in time trends with age. The link with exposure suggests that the time trends in melanoma are driven by variations in damage to melanocytes in early life that increases sensitivity to sunlight. This has implications for the general understanding of melanoma etiology and for health education.
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References
VanDerEsch EP, Muir CS, Neetoux J, et al. Temporal change in díagnostic criteria as a cause of the increase of malignant melanoma over time is unlikely. Int J Cancer 1991; 47: 483–90.
Gordon T, Crittenden M, Haenszel W. Cancer mortality trends in the United States, 1930–1955. In: End results and mortality trends in cancer. NCI Monogr 1961; 60: 133–298.
Lee JAH, Petersen GR, Stevens RG, Vesanen K. The influence of age, year of birth, and date on mortality from malignant melanoma in the populations of England and Wales, Canada, and the White population of the United States. Am J Epidemiol 1979; 110: 734–9.
Muir CS, Nectoux J. Time trends: malignant melanoma of the skin. In: Magnus K, ed. Trends in Cancer Incidence. Washington: Hemisphere Publishing Corporation, 1982; 365–85.
Green A, Sorahan T, Pope D, et al. Moles in Australian and British school children. Lancet 1988; 2: 1497.
Holman CD, Armstrong BK. Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: an analysis separating histogenetic types. JNCI 1984; 73: 75–82.
Mack TM, Floderus B. Malignant melanoma risk by nativity, place of residence at diagnosis, and age at migration. Cancer Causes Control 1991; 2: 401–11.
Holman CDJ, James IR, Gattey PH, Armstrong BK. An analysis of trends in mortality from malignant melanoma of the skin in Australia. Int J Cancer 1980; 26: 703–9.
Venzon DJ, Moolgavkar SH. Cohort analysis of malignant melanoma in five countries. Am J Epidemiol 1984; 119: 62–70.
Thom M, Bergstrom R, Adami HO, Ringborg U. Trends in the incidence of malignant melanoma in Sweden, by anatomic site, 1960–1984. Am J Epidemiol 1990; 132: 1066–77.
Scotto J, Pitcher H, Lee JAH. Indications of decreasing trends in skin melanoma risks among Whites in the United States. Int J Cancer 1991; 49: 490–7.
Roush GC, McKay L, Holford TR. A reversal in the long-term increase in deaths attributable to malignant melanoma. Cancer 1992; 69: 1714–20.
Crombie IK. Variation of melanoma incidence with latitude in North America and Europe. Br J Cancer 1979; 40: 774–81.
Swerdlow AJ. Incidence of malignant melanoma of the skin in England and Wales and its relationship to sunshine. BMJ 1979; 2: 1324–7.
Magnus K. The Nordic profile of skin cancer incidence. A comparative epidemiological study of the three main types of skin cancer. Int J Cancer 1991; 47: 12–9.
Ries LAG, hankey BF, Miller BA, Hartman AM, Edwards BK. Cancer Statisties Review 1973–88. Bethesda, MD: National Cancer Institute, 1991; NIH Pub. No.91–2789.
Lee JAH. Epidemiology of malignant melanoma. In: Kirkham N, Cotton DWK, Lallenand R, et al, eds. Melanoma. London: Springer-Verlag Publishing, 1991: 1–9.
Karagas MR, Thomas DB, Roth GJ, Johnson LK, Weiss NS. The effects of changes in health care delivery on the reported incidence of cutaneous melanoma in western Washington State. Am J Epidemiol 1992; 133: 58–62.
Koh HK, Clapp RW, Barnett JM, et al. Systematic under-reporting of cutaneous malignant melanoma in Massachusetts. J Am Acad Dermatol 1991; 24: 545–50.
Polissar L. The effect of migration on comparison of disease rates in geographic studies in the United States. Am J Epidemiol 1980; 111: 175–82.
Lindegard B. Mortality and fatality of cutaneous malignant melanoma in Sweden, 1982–1986. Biomed Pharmacother 1990; 44: 495–501.
Gong G, Whittlemore AS, West D, Moore DH. Cutaneous melanoma at Lawrence Livermore National Laboratory: Comparison with rates in two San Francisco Bay area counties. Cancer Causes Control 1991; 3: 191–7.
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Dr Lee is at the School of Public Health, University of Washington, Seattle, WA, USA. Dr Scotto is with the Division of Biostatistics & Epidemiology, Georgetown University, Washington, DC, USA. Address correspondence to Dr Lee, Department of Epidemiology SC 36, School of Public Health, University of Washington, Seattle, WA 98195, USA.
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Lee, J.A.H., Scotto, J. Melanoma: linked temporal and latitude changes in the United States. Cancer Causes Control 4, 413–418 (1993). https://doi.org/10.1007/BF00050859
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DOI: https://doi.org/10.1007/BF00050859