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Alcoholic beverage consumption and risk of breast cancer in Spain

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The relation between alcoholic beverage consumption and risk of breast cancer was examined. We used data from a population-based, case-control study that included almost all incident cases occurring in five Spanish regions from February 1990 to July 1991. A total of 762 women between 18 and 75 years of age, with a histologically confirmed, first diagnosis of breast cancer, were compared with 988 control women. Alcoholic beverage intake was measured by an interviewer-administered, semiquantitative food-frequency questionnaire. We used ‘nondrinkers’ as the reference category and divided the remainder into four categories according to alcohol intake. The multiple logistic analyses included not only alcohol intake but also possible confounding factors such as total caloric intake, age, socioeconomic status, and reproductive and medical histories. Even at moderate levels of alcohol intake (less than 8 g/day), a 50 percent increase in risk of breast cancer was found. The trend across categories of intake was statistically significant for wine and distilled drinks, as well as total alcohol intake. Consumption of 20 g or more of alcohol per day was associated with a 70 percent elevation in breast cancer risk compared with that of nondrinkers (adjusted relative risk (RR)=1.7,95 percent confidence interval = 1.3–2.3). Although the magnitude of the RR observed in our study was modest, our findings provide further support for a positive association between alcohol consumption and risk of breast cancer.

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References

  1. Blot WJ. Alcohol and cancer. Cancer Res 1992; 52 (Suppl.): 2119s–23s.

  2. Williams RR, Horm JW. Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: Interview study from the Third National Cancer Survey. JNCI 1977; 58: 525–47.

    Google Scholar 

  3. Rosenberg L, Slone D, Shapiro S, et al. Breast cancer and alcoholic-beverage consumption. Lancet 1982; i: 267–70.

    Google Scholar 

  4. Lé MG, Hill C, Kramar A, Flamant R. Alcoholic beverage consumption and breast cancer in a French case-control study. Am J Epidemiol 1984; 120: 350–7.

    Google Scholar 

  5. Hiatt RA, Bawol RD. Alcoholic beverage consumption and breast cancer incidence. Am J Epidemiol 1984; 120: 676–83.

    Google Scholar 

  6. Talamini R, La Vecchia C, Decarli A, et al. Social factors, diet and breast cancer in a Northern Italian population. Br J Cancer 1984; 49: 723–9.

    Google Scholar 

  7. La Vecchia C, Decarli A, Franceschi S, Pampallona S, Tognoni G. Alcohol consumption and the risk of breast cancer in women. JNCI 1985; 75: 61–5.

    Google Scholar 

  8. O'Connell DL, Hulka BS, Chambless LE, Wilkinson WE, Deubner DC. Cigarette smoking, alcohol consumption, and breast cancer risk. JNCI 1987; 78: 229–34.

    Google Scholar 

  9. Schatzkin A, Jones Y, Hoover RN, et al. Alcohol consumption and breast cancer in the epidemiologic follow-up study of the first National Health and Nutrition Examination Survey. N Engl J Med 1987; 316: 1169–73.

    Google Scholar 

  10. Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Hennekens CH, Speizer FE. Moderate alcohol consumption and the risk of breast cancer. N Engl J Med 1987; 316: 1174–80.

    Google Scholar 

  11. Harvey EB, Schairer C, Brinton LA, Hoover RN, Fraumeni JFJr. Alcohol consumption and breast cancer. JNCI 1987; 78: 657–61.

    Google Scholar 

  12. Hiatt RA, Klatsky AL, Armstrong MA. Alcohol consumption and the risk of breast cancer in a prepaid health plan. Cancer Res 1988; 48: 2284–7.

    Google Scholar 

  13. Rohan TE, McMichael AJ. Alcohol consumption and risk of breast cancer. Int J Cancer 1988; 41: 695–9.

    Google Scholar 

  14. Young T. Breast cancer and alcohol consumption habits (Abstract). Am J Epidemiol 1988; 128: 913.

    Google Scholar 

  15. Garfinkel L, Boffetta P, Stellman SD. Alcohol and breast cancer: A cohort study. Prev Med 1988; 17: 686–93.

    Google Scholar 

  16. Toniolo P, Riboli E, Protta F, Charrel M, Cappa APM. Breast cancer and alcohol consumption: A case-control study in northern Italy. Cancer Res 1989; 49: 5203–6.

    Google Scholar 

  17. Kato I, Tominaga S, Terao C. Alcohol consumption and cancer of hormone-related organs in females. Jap J Clin Oncol 1989; 19: 202–7.

    Google Scholar 

  18. Ewertz M. Alcohol consumption and breast cancer risk in Denmark. Cancer Causes Control 1991; 2: 247–52.

    Google Scholar 

  19. Ferraroni M, Decarli A, Willett WC, Marubini E. Alcohol and breast cancer risk: A case-control study from Northern Italy. Int J Epidemiol 1991; 20: 859–64.

    Google Scholar 

  20. Longnecker MP, Berlin JA, Orza MJ, Chalmers TC. A meta-analysis of alcohol consumption in relation to the risk of breast cancer. JAMA 1988; 260: 652–6.

    Google Scholar 

  21. Howe G, Rohan T, Decarli A, et al. The association between alcohol and breast cancer risk: Evidence from the combined analysis of six dietary case-control studies. Int J Cancer 1991; 47: 707–10.

    Google Scholar 

  22. Byers T, Funch DP. Alcohol and breast cancer (Letter). Lancet 1982; i: 799–800.

    Google Scholar 

  23. Begg CB, Walker AM, Wessen B, Zelen M. Alcohol consumption and breast cancer (Letter). Lancet 1983; i: 293–4.

    Google Scholar 

  24. Webster LA, Layde PM, Wingo PA, Ory HW (The Cancer and Steroid Hormone Study Group). Alcohol consumption and risk of breast cancer. Lancet 1983; ii: 724–6.

    Google Scholar 

  25. Paganini-Hill A, Ross RK. Breast cancer and alcohol consumption. Lancet 1983; ii: 626–7.

    Google Scholar 

  26. Harris RE, Wynder EL. Breast cancer and alcohol consumption: A study in weak associations. JAMA 1988; 259: 2867–71.

    Google Scholar 

  27. Schatzkin A, Green S, Carter C, et al. Alcohol and breast cancer in the Framingham Heart Study (Abstract). Am J Epidemiol 1988; 128: 913.

    Google Scholar 

  28. Chu SY, Lee NC, Wingo PA, Webster LA. Alcohol consumption and the risk of breast cancer. Am J Epidemiol 1989; 130: 867–77.

    Google Scholar 

  29. Rosenberg L, Palmer JR, Miller DR, Clarke EA, Shapiro S. A case-control study of alcoholic beverage consumption and breast cancer. Am J Epidemiol 1990; 131: 6–14.

    Google Scholar 

  30. Martin-Moreno JM, Willett WC, Gorgojo L, et al. Dietary habits, nutrition and breast cancer in Spain: a population-based case-control study. In: Martin-Moreno JM. Nutritional epidemiology of breast cancer in Spain. Doctoral thesis, Harvard School of Public Health, Boston, MA, 1992: 66–114.

  31. Martin-Moreno JM, Boyle P, Gorgojo L, et al. Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol 1993 (in press).

  32. Varela G. Tablas de composicion de alimentos. Madrid: Instituto de Nutricion de C.S.I.C., 1980.

    Google Scholar 

  33. Jimenez A, Cervera P. Tabla de composicion de alimentos. Barcelona: Laboratorios Wander, 1988.

    Google Scholar 

  34. Andujar M, Morciras-Varela O, Gil F. Tablas de composicion de alimentos. Madrid: Instituto de Nutricion y Bromatologia (C.S.I.C.), 1990.

    Google Scholar 

  35. Aguilar M. Dietetica: Un Programa para la Nutricion, Version 2.0. Madrid: CONAYCITE, 1991.

    Google Scholar 

  36. Baker RJ, Clarke MRB, Nelder JA. The Generalised Linear Interactive Modelling (GLIM) System, Release 3.77. Oxford, UK: Numerical Algorithms Group, 1985.

    Google Scholar 

  37. Willett WC. Implications of total energy intake for epidemiologic studies of breast and colon cancer. Am J Clin Nutr 1987; 45: 354–60.

    Google Scholar 

  38. Willett WC, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124: 17–27.

    Google Scholar 

  39. Van't Veer P, Kok FJ, Hermus RJJ, Sturmans F. Alcohol dose, frequency and age at first exposure in relation to the risk of breast cancer. Int J Epidemiol 1989; 18: 511–7.

    Google Scholar 

  40. Gapstur SM, Potter JD, Sellers TA, Folsom AR. Increased risk of breast cancer with alcohol consumption in postmenopausal women. Am J Epidemiol 1992; 136: 1221–31.

    Google Scholar 

  41. Rohan TE, Cook MG. Alcohol consumption and risk of benign proliferative epithelial disorders of the breast in women. Int J Cancer 1989; 43: 631–6.

    Google Scholar 

  42. Wang DY, Fentiman IS. Epidemiology and endocrinology of benign breast disease. Breast Cancer Res Treat 1985; 6: 5–36.

    Google Scholar 

  43. London SJ, Connolly JL, Schnitt SJ, Colditz GA. A prospective study of benign breast disease and the risk of breast cancer. JAMA 1992; 267: 941–4.

    Google Scholar 

  44. Singletary KW, McNary MQ, Odoms AM, Nelshoppen J, Wallig MA. Ethanol consumption and DMBA-induced mammary carcinogenesis in rats. Nutr Cancer 1991; 16: 13–23.

    Google Scholar 

  45. Gavaler JS, Van Thiel DH. Reproductive consequences of alcohol abuse: males and females compared and contrasted. Mutat Res 1987; 186: 269–77.

    Google Scholar 

  46. McDermott EWM, O'Dwyer PJ, O'Higgins NJ. Dietary alcohol intake does not increase the incidence of experimentally induced mammary carcinoma. Eur J Surg Oncol 1992; 18: 251–4.

    Google Scholar 

  47. Hackney JF, Engelman RW, Good RA. Ethanol calories do not enhance breast cancer in isocalorically fed C3H/Ou mice. Nutr Cancer 1992; 18: 245–53.

    Google Scholar 

  48. William RR. Breast and thyroid cancer and malignant melanoma prompted by alcohol-induced pituitary secretion of prolactin TSH and MSH. Lancet 1976; i: 996–9.

    Google Scholar 

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This work was supported by Grant No. 89/0059 from the Spanish “Fondo de Investigacion Sanitaria.” Dr Martin-Moreno is indebted to the Italian “Fondazione per la Formazione Oncologica” for awarding him a “Paolo Baffi” Fellowship in 1991–1992, and to the Spanish “Fundacion Mapfre Medicina” for a research fellowship award in 1991. Dr Gorgojo is a postdoctoral fellow of the “Programa de Formación de Personal del Instituto de Salud Carlos III.”

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Martin-Moreno, J.M., Boyle, P., Gorgojo, L. et al. Alcoholic beverage consumption and risk of breast cancer in Spain. Cancer Causes Control 4, 345–353 (1993). https://doi.org/10.1007/BF00051337

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