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Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma

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A hospital-based case-control study of pancreatic cancer was conducted in Athens in 1991–92. One hundred and eighty-one patients operated on for cancer of the exocrine pancreas in eight teaching hospitals formed the case series, whereas hospital patient controls and hospital visitor controls formed two independent comparison series. Cases and controls were matched by hospital, gender, and age in 1:1:1 ratio, and every matched triplet was interviewed in person by the same researcher. Results indicate that tobacco smoking increased the risk of pancreatic cancer, whereas neither coffee drinking nor consumption of alcoholic beverages were associated with the disease. Diabetes mellitus, cholelithiasis, and pancreatitis were associated positively with risk of pancreatic cancer, whereas allergic asthma was inversely (but not significantly) related to the disease. There was a suggestion that earlier age at menarche was associated with increased risk of pancreatic cancer and that parous women were at lower risk. No consistent associations were noted with respect to gastrectomy, other medical conditions or operations, birth order, height, weight, broad occupational groups, or other reproductive variables. The two comparison series were remarkably similar with respect to the whole spectrum of the study variables.

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References

  1. Tomatis L, ed. Cancer: Causes, Occurrence and Control. Lyon, France: International Agency for Research on Cancer, 1990; IARC Sci. Pub. No. 100.

    Google Scholar 

  2. Katsouyanni K, Kogevinas M, Dontas N, Maisonneuve P, Boyle P, Trichopoulos D. Mortality from Malignant Neoplasms in Greece 1960–1985 (in Greek). Athens, Greece: Greek Cancer Society, 1990: 1–125.

    Google Scholar 

  3. Boyle P, Hsieh C-c, Maisonneuve P, et al. Epidemiology of pancreas cancer (1988). Int J Pancreatol 1989; 5: 327–46.

    Google Scholar 

  4. International Agency for Research on Cancer. Tobacco Smoking. Lyon, France: IARC, 1986; IARC Monogr Eval Carcinog Risks Humans, Vol. 38.

    Google Scholar 

  5. Breslow NE, Day NE, eds. Statistical Methods in Cancer Research, Vol. 1. The Analysis of Case-control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.

    Google Scholar 

  6. SAS Institute, Inc. SAS User's Guide. Cary, NC: SAS Institute, Inc., 1990.

    Google Scholar 

  7. Hsieh C-c, Tzonou A, Zavitsanos X, Kaklamani E, Lan S-j, Trichopoulos D. Age at first establishment of chronic hepatitis B virus infection and hepatocellular carcinoma risk. A birth order study. Am J Epidemiol 1992; 136: 1115–21.

    Google Scholar 

  8. International Agency for Research on Cancer. Alcohol Drinking. Lyon, France: IARC, 1988. IARC Monogr Eval Carcinog Risks Humans, Vol. 44.

    Google Scholar 

  9. Falk RT, Pickle LW, Fontham ET, Correa P, Fraumeni JFJr. Life-style risk factors for pancreatic cancer in Louisiana: A case-control study. Am J Epidemiol 1988; 128: 324–36.

    Google Scholar 

  10. Cuzick J, Babiker AG. Pancreatic cancer, alcohol, diabetes mellitus and gall-bladder disease. Int J Cancer 1989; 43: 415–21.

    Google Scholar 

  11. Olsen GW, Mandel JS, Gibson RW, Wattenberg LW, Schuman LM. A case-control study of pancreatic cancer and cigarettes, alcohol, coffee and diet. Am J Public Hlth 1989; 79: 1016–9.

    Google Scholar 

  12. Hirayama T. Epidemiology of pancreatic cancer in Japan. Jpn J Clin Oncol 1989; 19: 208–15.

    Google Scholar 

  13. Farrow DC, Davis S. Risk of pancreatic cancer in relation to medical history and the use of tobacco, alcohol and coffee. Int J Cancer 1990; 45: 816–20.

    Google Scholar 

  14. Ghadirian P, Simard A, Baillargeon J. Tobacco, alcohol, and coffee and cancer of the pancreas. A populationbased, case-control study in Quebec, Canada. Cancer 1991; 67: 2664–70.

    Google Scholar 

  15. Howe GR, Jain M, Burch JD, Miller AB. Cigarette smoking and cancer of the pancreas. Evidence from a population-based case-control study in Toronto, Canada. Int J Cancer 1991; 47: 323–8.

    Google Scholar 

  16. Lyon JL, Mahoney AW, French TK, Moser RJr. Coffee consumption and the risk of cancer of the exocrine pancreas: a case-control study in a low-risk population. Epidemiology 1992; 3: 164–70.

    Google Scholar 

  17. Manousos O, Papadimitriou C, Trichopoulos D, Polychronopoulou A, Koutselinis A, Zavitsanos X. Epidemiologic characteristics and trace elements in pancreatic cancer in Greece. Cancer Detect Prev 1981; 4: 439–42.

    Google Scholar 

  18. Clavel F, Benhamou E, Auquier A, Tarayre M, Flamant R. Coffee, alcohol, smoking and cancer of the pancreas: a case-control study. Int J Cancer 1989; 43: 17–21.

    Google Scholar 

  19. Jain M, Howe GR, St Louis P, Millar AB. Coffee and alcohol as determinants of risk of pancreas cancer: A case-control study from Toronto. Int J Cancer 1991; 47: 384–9.

    Google Scholar 

  20. International Agency for Research on Cancer. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon, France: IARC, 1991; IARC Monogr Eval Carcinog Risks Humans, Vol. 51.

    Google Scholar 

  21. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, Runia S, Boyle P. Life-time consumption of alcoholic beverages, tea and coffee and exocrine carcinoma of the pancreas: A population-based case-control study in the Netherlands. Int J Cancer 1992; 50: 514–22.

    Google Scholar 

  22. MacMahon B, Yen S, Trichopoulos D, Warren K, Nardi G. Coffee and cancer of the pancreas. N Engl J Med 1981; 304: 630–3.

    Google Scholar 

  23. Bueno de Mesquita HB, Moerman CJ, Runia S, Maisonneuve P. Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas? Int J Cancer 1990; 46: 435–44.

    Google Scholar 

  24. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, Walker AM. Anthropometric and reproductive variables, and exocrine carcinoma of the pancreas: A population-based case-control study in the Netherlands. Int J Cancer 1992; 52: 24–9.

    Google Scholar 

  25. Howe GR, Jain M, Miller AB. Dietary factors and risk of pancreatic cancer: Results of a Canadian populationbased case-control study. Int J Cancer 1990; 45: 604–8.

    Google Scholar 

  26. Ghadirian P, Simard A, Baillargeon J, Maisonneuve P, Boyle P. Nutritional factors and pancreatic cancer in the francophone community in Montréal, Canada. Int J Cancer 1991; 47: 1–6.

    Google Scholar 

  27. Trichopoulos D, Tzonou A, Katsouyanni K, Trichopoulou A. Diet and cancer:methodological complexities and case-control studies in Greece. In: Mettlin CJ, Aoki K, eds. Recent Progress in Research on Nutrition and Cancer. New York, Wiley-Liss 1990: 45–53.

    Google Scholar 

  28. Mack TM, Yu MC, Hanisch R, Henderson BE. Pancreas cancer and smoking, beverage consumption and past medical history. JNCI 1986; 76: 49–60.

    Google Scholar 

  29. Mack TM. Pancreas. In: Schottenfeld D, Fraumeni JFJr, eds. Cancer Epidemiology and Prevention. Philadelphia: Saunders, 1982: 638–67.

    Google Scholar 

  30. Howatson AG, Carter DC. Pancreatic carcinogenesis—enhancement by cholecystokinin in the hamster-nitrosamine model. Brit J Cancer 1985; 51: 107–14.

    Google Scholar 

  31. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, Walker AM. Aspects of medical history and exocrine carcinoma of the pancreas. A population-based casecontrol study in the Netherlands. Int J Cancer 1992; 52: 17–23.

    Google Scholar 

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This study was supported by a grant to Harvard University from the Leon Lemos Foundation.

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Kalapothaki, V., Tzonou, A., Hsieh, Cc. et al. Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma. Cancer Causes Control 4, 375–382 (1993). https://doi.org/10.1007/BF00051341

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  • DOI: https://doi.org/10.1007/BF00051341

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