Abstract
After treatment for 3 weeks with aristolochic acid (AA) in daily doses of 5.0 mg/kg mice were kept under observation for approximately 1 year. During this period papillomatous changes occurred in the forestomach. At a later stage, squamous cell carcinomas were observed in all the animals. In one case, an adenocarcinoma was found in the glandular stomach. In addition, malignant lymphomas were found, as well as adenomas of the kidneys, carcinomas of the lungs, and haemangiomas of the uteri.
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References
Mengs U (1983) On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Arch Toxicol 52: 209–220
Mengs U, Lang W, Poch IA (1982) The carcinogenic action of aristolochic acid in rats. Arch Toxicol 51: 107–119
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This is a short report on the experiments conducted. All results are available from the author on request
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Mengs, U. Tumour induction in mice following exposure to aristolochic acid. Arch Toxicol 61, 504–505 (1988). https://doi.org/10.1007/BF00293699
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DOI: https://doi.org/10.1007/BF00293699