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On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid

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Abstract

The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.

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  1. Department of Pathology and Toxicology, Dr. Madaus & Co., Ostmerheimer Strasse 198, D-5000, Köln 91, Federal Republic of Germany

    U. Mengs

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Mengs, U. On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Arch Toxicol 52, 209–220 (1983). https://doi.org/10.1007/BF00333900

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  • DOI: https://doi.org/10.1007/BF00333900

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