Skip to main content
SpringerLink
Log in

Estimation of individual uptake of trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene from biological parameters

  • Published:
International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

Summary

The results of single exposure studies with exposure to trichloroethylene, TRI, (Monster et al., 1976), to 1,1,1-trichloroethane, MC, (Monster et al., 1979b) and to tetrachloroethylene, PERC, (Monster et al., 1979c) were used to study the precision in estimating the individual uptake from measured biological parameters after exposure. With simple linear and multiple linear regression analysis the individual uptake of TRI, MC and PERC was estimated from the concentrations of solvents and metabolites in biological media (blood, urine, exhaled air) at 2 h and at 20 h after exposure. The best results are obtained by estimation from the concentrations in blood, particularly of the solvents themselves. Including results of simultaneously measured concentrations in exhaled air or urine did not improve the estimate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Monster, A.C., Boersma, G.: Simultaneous determination of trichloroethylene and metabolites in blood and exhaled air by gas chromatography. Int. Arch. Occup. Environ. Health 35, 155–163 (1975)

    Google Scholar 

  • Monster, A.C., Boersma, G., Duba, W.C.: Pharmacokinetics of trichloroethylene in volunteers; influence of wick load and exposure concentration. Int. Arch. Occup. Environ. Health 38, 87–102 (1976)

    Google Scholar 

  • Monster, A.C., Boersma, G., Duba, W.C.: Kinetics of trichloroethylene in repeated exposure of volunteers. Int. Arch. Occup. Environ. Health 42, 283–292 (1979a)

    Google Scholar 

  • Monster, A.C., Boersma, G., Steenweg, H.: Kinetics of 1,1,1-trichloroethane in volunteers; influence of exposure concentration and work load. Int. Arch. Occup. Environ. Health 42, 293–301 (1979b)

    Google Scholar 

  • Monster, A.C., Boersma, G., Steenweg, H.: Kinetics of tetrachloroethylene in volunteers; influence of exposure concentration and work load. Int. Arch. Occup. Environ. Health 42, 303–309 (1979c)

    Google Scholar 

  • Nie, N.H., Hull, C.H., Jenkins, J.G., Steinbrenner, K., Bent, D.H.: Statistical Package for the Social Sciences. 2nd edition, pp. 320–342. New York: Mc Graw Hill 1975

    Google Scholar 

  • Stewart, R.D., Hake, C.L., Peterson, J.E.: Use of breath analysis to monitor trichloroethylene exposure. Arch. Environ. Health 29, 6–13 (1974)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Coronel Laboratory, Institute of Occupational and Environmental Health, Faculty of Medicine, University of Amsterdam, Eerste Constantijn Huygensstraat 20, Amsterdam, The Netherlands

    A. C. Monster M. D.

  2. Statistical department of the Jan Swammerdam Institute, Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands

    J. M. Houtkooper

Authors
  1. A. C. Monster M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. M. Houtkooper
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Monster, A.C., Houtkooper, J.M. Estimation of individual uptake of trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene from biological parameters. Int. Arch Occup Environ Heath 42, 319–323 (1979). https://doi.org/10.1007/BF00377786

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00377786

Key words

Search

Navigation