Summary
Four male volunteers inhaled for 4 h 70 and 140 ppm trichloroethylene (TRI) at rest and also at rest combined with exercise. To estimate the amount retained in the body (dose), minute volume and concentration in exhaled air were determined. Concentrations of TRI, trichloroethanol (TCE) and trichloroacetic acid (TCA) were determined in blood. Exhaled air was analysed for TRI and TCE; urine for TCE and TCA.
During more than 60 h after exposure the concentration of TRI and TCE in blood and exhaled air were proportional to the dose, but the interindividual variation was large; workload increased the dose, but no influence was found on the distribution and metabolism. The total recovery was 67%; 10% as TRI by the lungs and in urine 39% as TCE and 18% as TCA.
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Monster, A.C., Boersma, G. & Duba, W.C. Pharmacokinetics of trichloroethylene in volunteers, influence of workload and exposure concentration. Int. Arch. Occup. Environ. Hlth 38, 87–102 (1976). https://doi.org/10.1007/BF00378619
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DOI: https://doi.org/10.1007/BF00378619