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Biotransformation of aloenin, a bitter glucoside constituent ofAloe arborescens, by rats

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Summary

Aloenin has been established to be 4-methoxy-6-(2-β-D-glucopyranosyloxy-4-hydroxy-6-methylphenyl)-2-pyrone; it shows an inhibitory activity for gastric juice secretion. Rats metabolized it to 4-methoxy-6-(2,4-dihydroxy-6-methylphenyl)-2-pyrone, 2,5-dimethyl-7-hydroxychromone and glucose, which were excreted in the feces and the urine. The distribution of the radioactivity originating from14C-labeled aloenin was studied. The tracer found in the kidney and the liver reached 60% of the amount administered 24 h after feeding and decreased rapidly in the next 24 h.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Hiroshima University, Higashisenda-machi, Naka-ku, 730, Hiroshima, (Japan)

    T. Hirata, S. Sakano & T. Suga

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  1. T. Hirata
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  2. S. Sakano
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  3. T. Suga
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Hirata, T., Sakano, S. & Suga, T. Biotransformation of aloenin, a bitter glucoside constituent ofAloe arborescens, by rats. Experientia 37, 1252–1253 (1981). https://doi.org/10.1007/BF01948341

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