Abstract
Female C57/BL/6 × DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of lymphocytes/monocytes and of neutrophils was observed with an almost complete regeneration in the exposure-free period. A reticulocytosis during and also after the exposure indicated a compensatory reaction in the erythroid cell system. Bone marrow pluripotent stem cells (CFU-S) were not affected up to 7.5 weeks. Erythroid committed cells (BFU-E and CFU-E) did react, with a reduction of CFU-E numbers at 7.5 and 11.5 weeks. A slight reduction of CFU-C numbers at 7.5 weeks indicated, in accordance with the peripheral blood data, a disturbance of the granulocytic cell series as well.
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Study supported by the BMFT (Bundesministerium für Forschung und Technologie), Bonn
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Seidel, H.J., Weber, L. & Barthel, E. Hematological toxicity of tetrachloroethylene in mice. Arch Toxicol 66, 228–230 (1992). https://doi.org/10.1007/BF01974021
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DOI: https://doi.org/10.1007/BF01974021