Summary
Three chlorinated hydrocarbons, proposed or already in use as industrial subsitutes for the hydrocarbon trichloroethylene, were tested for in vitro transforming potential in a Fischer rat embryo cell system (F1706), which previously has been shown to be sensitive to transformation by chemical carcinogens. Trichloroethylene and the three substitutes (1,1,1 trichloroethane, tetrachloroethylene and methylene chloride) all were found to induce transformation, the three substitutes being equal or more efficient transforming agents.
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References
DHEW Publication No. (NIH) 76-802. 1976. Carcinogenesis Technical Report No. 2 on the Bioassay of TCE.
Freeman, A. E., H. J. Igel, and P. J. Price. 1975. Carcinogenesis in vitro. I. In vitro transformation of rat embryo cells: Correlation with the known tumorigenic activities of chemicals in rodents. In Vitro 11: 107–116.
Macpherson, I. 1973. Soft agar techniques. In: P. F. Kruse, Jr., and M. K. Patterson, Jr. (Eds.),Tissue Culture Methods and Applications, Academic Press, New York, pp. 276–280.
Schaeffer, W. I., and K. Friend. 1976. Efficient detection of soft agar grown colonies using a tetrazolium salt. Cancer Lett. 1: 259–262.
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This work was supported by Contract N01-CP-43240 within The Virus Cancer Program of the National Cancer Institute.
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Price, P.J., Hassett, C.M. & Mansfield, J.I. Transforming activities of trichloroethylene and proposed industrial alternatives. In Vitro 14, 290–293 (1978). https://doi.org/10.1007/BF02616038
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DOI: https://doi.org/10.1007/BF02616038