Capillary changes with fenestrations in the contralateral soleus muscle of the rat following unilateral limb immobilization

doi:10.1007/s007760050070

Journal of Orthopaedic Science

Volume 4, Issue 1, January 1999, Pages 28-31

https://doi.org/10.1007/s007760050070 Get rights and content

Abstract

Using electron microscopy, we examined structural changes in the capillaries of the immobilized and contralateral soleus muscles in the rat after the unilateral limb had been immobilized for 4 weeks. Individual contralateral muscle fibers showed a normal structure, compared with the structure in the immobilized muscle fibers. Most capillaries in the contralateral muscle were of the continuous type. However, about 5% of the examined capillaries in these muscles in each rat had fenestrations. The non-nuclear portions of the endothelial cells in these capillaries were extremely thin and were perforated by several fenestrations that were bridged by a single-layered diaphragm. The fenestration of capillaries in the contralateral muscle may have been caused by some the unilateral limb immobilization.

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Citation Excerpt :
This finding suggests that the non-thermal effects of the pulsed US inhibited the development of disuse muscle atrophy in the US group partly. Previous reports showed that the capillary diameter and the number of capillaries were decreased in atrophied muscle because of an inactive and reduced metabolism (Desplanches et al. 1990; Kano et al. 2000; Oki et al. 1999). A decrease in the number of capillaries was also observed in this study because the ratio of the number of capillaries to muscle fiber was decreased significantly in the Im group compared with the control group.
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