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A meta-analysis to determine the effect of pharmacological and non-pharmacological treatments on fibromyalgia symptoms comprising OMERACT-10 response criteria

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Abstract

Fibromyalgia is characterized by widespread pain, sleep problems, fatigue, functional impairment, psychological distress, and cognitive dysfunction. The objective of this meta-analysis is to synthesize the available data on the effectiveness of pharmacological and non-pharmacological interventions across all domains included in the Outcome Measures in Rheumatology Clinical Trials (OMERACT-10) fibromyalgia response definitions, and to examine response based on these definitions. We searched Cochrane, PubMed, Scopus, and the reference lists of articles for randomized controlled trials of any drug formulation or non-pharmacological intervention used for fibromyalgia treatment. We extracted efficacy data regarding pain, sleep, physical function, fatigue, anxiety, depression, and cognition. The available data were insufficient to draw definite conclusions regarding response. Indirect evidence indicates that it may be expected with the use of serotonin noradrenaline reuptake inhibitors (SNRIs), noradrenaline reuptake inhibitors (NRIs), and multidisciplinary treatment.

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Acknowledgments

The authors would like to thank Anastasios Boutsiadis for his support and assistance in the statistical analysis.

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Authors and Affiliations

  1. Pain Relief and Palliative Care Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

    Despoina Papadopoulou, Ioanna Siafaka & Athina Vadalouca

  2. National and Kapodistrian University of Athens, Athens, Greece

    Argyro Fassoulaki

  3. Institute for Continuing Medical Education of Ioannina, Ioannina, Greece

    Christos Tsoulas

Authors
  1. Despoina Papadopoulou
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  2. Argyro Fassoulaki
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  3. Christos Tsoulas
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  4. Ioanna Siafaka
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  5. Athina Vadalouca
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Correspondence to Despoina Papadopoulou.

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Papadopoulou, D., Fassoulaki, A., Tsoulas, C. et al. A meta-analysis to determine the effect of pharmacological and non-pharmacological treatments on fibromyalgia symptoms comprising OMERACT-10 response criteria. Clin Rheumatol 35, 573–586 (2016). https://doi.org/10.1007/s10067-015-3144-2

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  • DOI: https://doi.org/10.1007/s10067-015-3144-2

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