Skip to main content
SpringerLink
Log in

Alcohol drinking and risk of localized versus advanced and sporadic versus familial prostate cancer in Sweden

  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Background: It is unknown whether the association of alcohol consumption with prostate cancer risk varies between localized and advanced cases, or between sporadic and familial cases.

Methods: We assessed recent alcohol drinking in a population-based case–control study of Swedish men, including 1499 cases and 1130 controls. Drinking status and average volume, frequency, and type of alcohol consumed were evaluated. Unconditional logistic regression was performed to estimate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for associations between alcohol consumption and prostate cancer risk.

Results: Prostate cancer cases were more likely than controls to be current or former, rather than never, drinkers. However, there was no association between recent total alcohol, beer, wine, and liquor consumption and risk of overall prostate cancer, nor advanced, sporadic, or familial prostate cancer. The OR for risk of overall disease among men who drank more than 135 g of total alcohol per week versus non-drinkers was 1.2 (95% CI: 0.9, 1.5), p trend =0.12. There was a marginal positive association between alcohol intake and risk of localized disease.

Conclusions: We detected no association between recent alcohol consumption and risk of advanced, sporadic, or familial prostate cancer, and a borderline positive association with localized disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

OR:

odds ratio

CI:

confidence interval

PSA:

prostate-specific antigen

References

  1. LK Dennis (2000) ArticleTitleMeta-analysis for combining relative risks of alcohol consumption and prostate cancer Prostate 42 IssueID1 56–66 Occurrence Handle10.1002/(SICI)1097-0045(20000101)42:1<56::AID-PROS7>3.0.CO;2-P Occurrence Handle1:STN:280:DC%2BD3c%2FkslWhsw%3D%3D Occurrence Handle10579799

    Article  CAS  PubMed  Google Scholar 

  2. RA Breslow DL Weed (1998) ArticleTitleReview of epidemiologic studies of alcohol and prostate cancer: 1971–1996 Nutr Cancer 30 IssueID1 1–13 Occurrence Handle1:STN:280:DyaK1c7mvVenuw%3D%3D Occurrence Handle9507506

    CAS  PubMed  Google Scholar 

  3. H Yu RE Harris EL Wynder (1998) ArticleTitleCase-control study of prostate cancer and socioeconomic factors Prostate 13 IssueID4 317–325

    Google Scholar 

  4. Hirayama T (1992) Life-style and cancer: from epidemiological evidence to public behavior change to mortality reduction of target cancers. J Natl Cancer Inst Monogr (12): 65–74

  5. AW Hsing RT Wang FL Gu et al. (1994) ArticleTitleVasectomy and prostate cancer risk in China Cancer Epidemiol Biomarkers Prev 3 IssueID4 285–288 Occurrence Handle1:STN:280:ByuA3sbnvF0%3D Occurrence Handle8061575

    CAS  PubMed  Google Scholar 

  6. E Stefani ParticleDe L Fierro E Barrios A Ronco (1995) ArticleTitleTobacco, alcohol, diet and risk of prostate cancer Tumori 81 IssueID5 315–320 Occurrence Handle1:STN:280:BymA1MjlsFY%3D Occurrence Handle8804446

    CAS  PubMed  Google Scholar 

  7. RB Hayes LM Brown JB Schoenberg et al. (1996) ArticleTitleAlcohol use and prostate cancer risk in US blacks and whites Am J Epidemiol 143 IssueID7 692–697 Occurrence Handle1:STN:280:BymB28fkvFY%3D Occurrence Handle8651231

    CAS  PubMed  Google Scholar 

  8. SD Putnam JR Cerhan AS Parker et al. (2000) ArticleTitleLifestyle and anthropometric risk factors for prostate cancer in a cohort of Iowa men Ann Epidemiol 10 IssueID6 361–369 Occurrence Handle10.1016/S1047-2797(00)00057-0 Occurrence Handle1:STN:280:DC%2BD3cvntVWqsA%3D%3D Occurrence Handle10964002

    Article  CAS  PubMed  Google Scholar 

  9. CR Sharpe J Siemiatycki (2001) ArticleTitleCase–control study of alcohol consumption and prostate cancer risk in Montreal, Canada Cancer Causes Control 12 IssueID7 589–598 Occurrence Handle10.1023/A:1011289108040 Occurrence Handle1:STN:280:DC%2BD3Mrgt1Wquw%3D%3D Occurrence Handle11552706

    Article  CAS  PubMed  Google Scholar 

  10. HD Sesso RS Paffenbarger SuffixJr IM Lee (2001) ArticleTitleAlcohol consumption and risk of prostate cancer: The Harvard Alumni Health Study Int J Epidemiol 30 IssueID4 749–755 Occurrence Handle10.1093/ije/30.4.749 Occurrence Handle1:STN:280:DC%2BD3MrhtlCqsQ%3D%3D Occurrence Handle11511598

    Article  CAS  PubMed  Google Scholar 

  11. RA Breslow L Wideroff BI Graubard et al. (1999) ArticleTitleAlcohol and prostate cancer in the NHANES I epidemiologic follow-up study First National Health and Nutrition Examination Survey of the United States. Ann Epidemiol 9 IssueID4 254–261 Occurrence Handle1:STN:280:DyaK1M3mtlOhtA%3D%3D

    CAS  Google Scholar 

  12. EA Platz MF Leitzmann EB Rimm WC Willett E Giovannucci (2004) ArticleTitleAlcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study Am J Epidemiol 159 IssueID5 444–453 Occurrence Handle10.1093/aje/kwh062 Occurrence Handle14977640

    Article  PubMed  Google Scholar 

  13. PA Kupelian EA Klein JS Witte VA Kupelian JH Suh (1997) ArticleTitleFamilial prostate cancer: a different disease J Urol 158 IssueID6 2197–2201 Occurrence Handle1:STN:280:DyaK1c%2FjtFKksw%3D%3D Occurrence Handle9366343

    CAS  PubMed  Google Scholar 

  14. AE Norrish CU McRae RJ Cohen RT Jackson (1999) ArticleTitleA population-based study of clinical and pathological prognostic characteristics of men with familial and sporadic prostate cancer BJU Int 84 IssueID3 311–315 Occurrence Handle10.1046/j.1464-410x.1999.00168.x Occurrence Handle1:STN:280:DyaK1MzpvFSmtA%3D%3D Occurrence Handle10468728

    Article  CAS  PubMed  Google Scholar 

  15. E Giovannucci EB Rimm Y Liu et al. (2003) ArticleTitleBody mass index and risk of prostate cancer in U.S. health professionals J Natl Cancer Inst 95 IssueID16 1240–1244 Occurrence Handle12928350

    PubMed  Google Scholar 

  16. K Wu JW Erdman SuffixJr. SJ Schwartz et al. (2004) ArticleTitlePlasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study Cancer Epidemiol Biomarkers Prev 13 IssueID2 260–269 Occurrence Handle1:CAS:528:DC%2BD2cXhtleis70%3D Occurrence Handle14973107

    CAS  PubMed  Google Scholar 

  17. BA Jonsson HO Adami M Hagglund et al. (2004) ArticleTitle160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer Int J Cancer 109 IssueID3 348–352 Occurrence Handle10.1002/ijc.11629 Occurrence Handle1:CAS:528:DC%2BD2cXhvVOgt7k%3D Occurrence Handle14961571

    Article  CAS  PubMed  Google Scholar 

  18. JT Dwyer (1997) ArticleTitleHuman studies on the effects of fatty acids on cancer: summary, gaps, and future research Am J Clin Nutr 66 IssueID6 Suppl 1581S–1586S Occurrence Handle1:CAS:528:DyaK2sXnslSku7c%3D Occurrence Handle9394718

    CAS  PubMed  Google Scholar 

  19. AW Hsing AP Chokkalingam YT Gao et al. (2002) ArticleTitleAllium vegetables and risk of prostate cancer: a population-based study J Natl Cancer Inst 94 IssueID21 1648–1651 Occurrence Handle1:CAS:528:DC%2BD38XosFOgsbs%3D Occurrence Handle12419792

    CAS  PubMed  Google Scholar 

  20. H Li MJ Stampfer EL Giovannucci et al. (2004) ArticleTitleA prospective study of plasma selenium levels and prostate cancer risk J Natl Cancer Inst 96 IssueID9 696–703 Occurrence Handle1:CAS:528:DC%2BD2cXjvVSjur8%3D Occurrence Handle15126606

    CAS  PubMed  Google Scholar 

  21. DM. Parkin (2001) ArticleTitleGlobal cancer statistics in the year 2000 Lancet Oncol 2 IssueID9 533–543 Occurrence Handle10.1016/S1470-2045(01)00486-7 Occurrence Handle1:STN:280:DC%2BD387ntlCrtw%3D%3D Occurrence Handle11905707

    Article  CAS  PubMed  Google Scholar 

  22. InstitutionalAuthorNameSwedish Cancer Register (2000) Cancer Incidence in Sweden 1998 Centre for Epidemiology Stockholm

    Google Scholar 

  23. LH Sobin C Wittekind (Eds) (2002) TNM Classification of Malignant Tumours EditionNumber6 John Wiley & Sons, Inc New York

    Google Scholar 

  24. G Maldonado S Greenland (1993) ArticleTitleSimulation study of confounder-selection strategies Am J Epidemiol 138 IssueID11 923–936 Occurrence Handle1:STN:280:ByuD2sfpsFw%3D Occurrence Handle8256780

    CAS  PubMed  Google Scholar 

  25. InstitutionalAuthorNameIARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1998) Alcohol Drinking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans IARC Press Lyon France

    Google Scholar 

  26. G Poschl F Stickel XD Wang HK Seitz (2004) ArticleTitleAlcohol and␣cancer: genetic and nutritional aspects Proc Nutr Soc 63 IssueID1 65–71 Occurrence Handle10.1079/PNS2003323 Occurrence Handle15070439

    Article  PubMed  Google Scholar 

  27. W Bounds KW Betzing RM Stewart RF Holcombe (1994) ArticleTitleSocial drinking and the immune response: impairment of lymphokine-activated killer activity Am J Med Sci 307 IssueID6 391–395 Occurrence Handle1:STN:280:ByuB2MnltFU%3D Occurrence Handle8198143

    CAS  PubMed  Google Scholar 

  28. LE Diaz A Montero M Gonzalez-Gross AI Vallejo J Romeo A Marcos (2002) ArticleTitleInfluence of alcohol consumption on immunological status: a review Eur J Clin Nutr 56 IssueIDSuppl 3 S50–S53 Occurrence Handle10.1038/sj.ejcn.1601486 Occurrence Handle1:CAS:528:DC%2BD38Xmt1Wns7s%3D

    Article  CAS  Google Scholar 

  29. GG Gordon K Altman AL Southren E Rubin CS Lieber (1976) ArticleTitleEffect of alcohol (ethanol) administration on sex-hormone metabolism in normal men N Engl J Med 295 IssueID15 793–797 Occurrence Handle1:CAS:528:DyaE28Xlslams7s%3D Occurrence Handle958274

    CAS  PubMed  Google Scholar 

  30. JH Mendelson NK Mello J Ellingboe (1977) ArticleTitleEffects of acute alcohol intake on pituitary-gonadal hormones in normal human males J Pharmacol Exp Ther 202 IssueID3 676–682 Occurrence Handle1:CAS:528:DyaE2sXls1amtrY%3D Occurrence Handle894528

    CAS  PubMed  Google Scholar 

  31. PH Gann (2002) ArticleTitleAndrogenic hormones and prostate cancer risk: status and prospects IARC Sci Publ 156 283–288 Occurrence Handle1:STN:280:DC%2BD38jit1Cmtw%3D%3D Occurrence Handle12484188

    CAS  PubMed  Google Scholar 

  32. KW Chung (1990) ArticleTitleEffects of chronic ethanol intake on aromatization of androgens and concentration of estrogen and androgen receptors in rat liver Toxicology 62 IssueID3 285–295 Occurrence Handle10.1016/0300-483X(90)90052-I Occurrence Handle1:CAS:528:DyaK3cXls1OhtL0%3D Occurrence Handle2389244

    Article  CAS  PubMed  Google Scholar 

  33. GP Risbridger JJ Bianco SJ Ellem SJ McPherson (2003) ArticleTitleOestrogens and prostate cancer Endocr Relat Cancer 10 IssueID2 187–191 Occurrence Handle10.1677/erc.0.0100187 Occurrence Handle1:CAS:528:DC%2BD3sXmsFCrsro%3D Occurrence Handle12790781

    Article  CAS  PubMed  Google Scholar 

  34. RR Monson JL Lyon (1975) ArticleTitleProportional mortality among alcoholics Cancer 36 IssueID3 1077–1079 Occurrence Handle1:STN:280:CSmD2c7kslM%3D Occurrence Handle1182660

    CAS  PubMed  Google Scholar 

  35. HO Adami JK McLaughlin AW Hsing et al. (1992) ArticleTitleAlcoholism and cancer risk: a population-based cohort study Cancer Causes Control 3 IssueID5 419–425 Occurrence Handle10.1007/BF00051354 Occurrence Handle1:STN:280:By2A1MbmsVU%3D Occurrence Handle1525322

    Article  CAS  PubMed  Google Scholar 

  36. H Tonnesen H Moller JR Andersen E Jensen K Juel (1994) ArticleTitleCancer morbidity in alcohol abusers Br J Cancer 69 IssueID2 327–332 Occurrence Handle1:STN:280:ByuC38flt1w%3D Occurrence Handle8297729

    CAS  PubMed  Google Scholar 

  37. AH Wu AS Whittemore LN Kolonel et al. (1995) ArticleTitleSerum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada Cancer Epidemiol Biomarkers Prev 4 IssueID7 735–741 Occurrence Handle1:CAS:528:DyaK2MXpslWnt74%3D Occurrence Handle8672990

    CAS  PubMed  Google Scholar 

  38. SD Putnam JR Cerhan AS Parker et al. (2000) ArticleTitleLifestyle and anthropometric risk factors for prostate cancer in a cohort of Iowa men Ann Epidemiol 10 IssueID6 361–369 Occurrence Handle10.1016/S1047-2797(00)00057-0 Occurrence Handle1:STN:280:DC%2BD3cvntVWqsA%3D%3D Occurrence Handle10964002

    Article  CAS  PubMed  Google Scholar 

  39. DM Parkin SL Whelan J Ferlay L Teppo DB Thomas (Eds) (2003) Cancer Incidence in Five Continents IARC Press Lyon, France

    Google Scholar 

  40. H Theobald SE Johansson P Engfeldt (2003) ArticleTitleInfluence of different types of alcoholic beverages on self-reported health status Alcohol Alcohol 38 IssueID6 583–588 Occurrence Handle14633646

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden

    Ellen T. Chang, Maria Hedelin, Hans-Olov Adami & Katarina A. Bälter

  2. Department of Radiation Sciences/Oncology, Umeå University, Umeå, Sweden

    Henrik Grönberg

Authors
  1. Ellen T. Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Hedelin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans-Olov Adami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Henrik Grönberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Katarina A. Bälter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ellen T. Chang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, E.T., Hedelin, M., Adami, HO. et al. Alcohol drinking and risk of localized versus advanced and sporadic versus familial prostate cancer in Sweden. Cancer Causes Control 16, 275–284 (2005). https://doi.org/10.1007/s10552-004-3364-2

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-004-3364-2

Keywords

Search

Navigation