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Personal and Occupational Exposure to Organic Solvents and Risk of Non-Hodgkin’s Lymphoma (NHL) in Women (United States)

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Abstract

Objectives: The authors assessed whether home and occupational exposure to organic solvents is associated with risk of NHL in women.

Methods: A population-based, incidence case-control study was conducted in upstate New York, involving 376 NHL cases and 463 population controls selected from the Medicare beneficiary files and State driver’s license records. Exposure information was obtained by telephone interview. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using an unconditional logistic regression model, adjusting for a number of risk factors for NHL.

Results: Overall, history of exposure to organic solvents was not associated with the risk of NHL. A statistically significant increase in risk associated with occupational exposure was observed only for the subjects whose first exposure occurred before 1970 (OR=1.87, 95% CI 1.03–3.40). When occupational and home exposures to paint thinners/turpentine were combined and analyzed together, the risk of NHL associated with any exposure, compared to no exposure at either job or home, was a statistically significantly increased (OR=1.46, 95% CI: 1.05–2.03). This observation was more pronounced for B-cell lymphoma and for low-grade lymphoma with ORs of 1.52 (95 CI: 1.08–2.14) and 2.20 (95% CI; 1.42–3.41), respectively.

Conclusions: The results of this case-control study do support of a major role of organic solvents in the development of NHL among women currently living in the US. However, relatively intensive exposure in past occupations and use of paint thinners/turpentine may deserve further investigation.

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Authors and Affiliations

  1. Department of Environmental Medicine, New York University of School of Medicine, New York, NY, USA

    Ikuko Kato, Karen L. Koenig, Hiroko Watanabe-Meserve, Miriam Moseson & Roy E. Shore

  2. Karmanos Cancer Institute/Department of Pathology, Wayne State University, Detroit, MI, USA

    Ikuko Kato

  3. Bureau of Chronic Disease Epidemiology and Surveillance, New York State Department of Health, Albany, NY, USA

    Mark S. Baptiste & Patricia P. Lillquist

  4. Department of Pathology, New York University Medical Center, New York, NY, USA

    Glauco Frizzera

  5. Department of Pathology, Weill Medical College of Cornell University, New York, NY, USA

    Glauco Frizzera

  6. Department of Pathology, Alta Bates Summit Medical Center, Berkeley, CA, USA

    Jerome S. Burke

  7. Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA

    Ikuko Kato

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  1. Ikuko Kato
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Correspondence to Ikuko Kato.

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Kato, I., Koenig, K.L., Watanabe-Meserve, H. et al. Personal and Occupational Exposure to Organic Solvents and Risk of Non-Hodgkin’s Lymphoma (NHL) in Women (United States). Cancer Causes Control 16, 1215–1224 (2005). https://doi.org/10.1007/s10552-005-0385-4

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