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Meat intake, meat mutagens and risk of lung cancer in Uruguayan men

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Abstract

Objective

To determine the role of meat consumption and related mutagens in the etiology of lung cancer, we conducted a case–control study among Uruguayan males in the time period 1996–2004.

Methods

The study included 846 cases and 846 controls, frequency matched on age and residence. Both series were drawn from the four major public hospitals in Montevideo, Uruguay. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) of lung cancer by quartiles of meat intake and mutagens.

Results

The highest vs. the lowest quartile of intake of total meat (OR = 2.04, 95% CI 1.42–2.92), red meat (OR = 2.33, 95% CI 1.63–3.32), and processed meat (OR = 1.79, 95% CI 1.22–2.65) was associated with increased risk of lung cancer, while intake of total white meat, poultry and fish was not. Heterocyclic amines (IQ, MeIQx, PhIP), nitrosamines and benzo[a]pyrene were directly associated with the risk of lung cancer (OR for PhIP 2.16, 95% CI 1.48–3.15). Moreover, both red meat and meat mutagens displayed higher risks among former smokers compared with current smokers.

Conclusions

This study suggests that red and processed meat and meat mutagens may play a role in the etiology of lung cancer.

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Acknowledgments

Grant sponsor: International Agency for Research on Cancer, Lyon, France.

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Authors and Affiliations

  1. Grupo de Epidemiología, Departamento de Anatomía Patológica, Facultad de Medicina, Hospital de Clínicas, Avenida Brasil 3080 department 402, 11300, Montevideo, Uruguay

    Eduardo De Stefani, Hugo Deneo-Pellegrini, Gisele Acosta & María Mendilaharsu

  2. International Agency for Research on Cancer, Lyon, France

    Paolo Boffetta, Paul Brennan & Gilles Ferro

  3. Departamento de Epidemiología y Métodos Científicos, Facultad de Medicina, Centro Latinoamericano de Economía Humana (CLAEH), Maldonado, Uruguay

    Alvaro L. Ronco

  4. Department of Biostatistics & Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

    Dagfinn Aune

Authors
  1. Eduardo De Stefani
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  2. Paolo Boffetta
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  3. Hugo Deneo-Pellegrini
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  4. Alvaro L. Ronco
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  5. Dagfinn Aune
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  6. Gisele Acosta
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  7. Paul Brennan
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  8. María Mendilaharsu
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  9. Gilles Ferro
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Corresponding author

Correspondence to Eduardo De Stefani.

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De Stefani, E., Boffetta, P., Deneo-Pellegrini, H. et al. Meat intake, meat mutagens and risk of lung cancer in Uruguayan men. Cancer Causes Control 20, 1635–1643 (2009). https://doi.org/10.1007/s10552-009-9411-2

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  • DOI: https://doi.org/10.1007/s10552-009-9411-2

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