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Meat intake and risk of non-Hodgkin lymphoma

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Abstract

We conducted a population-based, case–control study to test the hypothesis that consumption of meat and meat-related mutagens increases the risk of non-Hodgkin lymphoma (NHL), and whether the associations are modified by N-acetyltransferase (NAT) 1 and 2. Participants (336 cases and 460 controls) completed a 117-item food frequency questionnaire. The risk of NHL was associated with a higher intake of red meat (OR = 1.5; CI, 1.1–2.2), total fat (OR = 1.4; CI, 1.0–2.1), and oleic acid (OR = 1.5; CI, 1.0–2.2). NHL risk was also associated with a higher intake of very well-done pork (OR = 2.5; 95 % CI, 1.4–4.3) and the meat-related mutagen MeIQx (OR = 1.6; 95 % CI, 1.1–2.3). Analyses of the major NHL histologic subtypes showed a positive association between diffuse large B cell lymphoma (DLBCL) and higher intake of red meat (OR = 2.1; 95 % CI, 1.1–3.9) and the association was largely due to meat-related mutagens as a positive association was observed for higher intakes of both MeIQx (OR = 2.4; 95 % CI, 1.2–4.6) and DiMeIQx (OR = 1.9; 95 % CI, 1.0–3.5). Although the OR for follicular lymphoma (FL) was also increased with a higher red meat intake (OR = 1.9; 95 % CI, 1.1–3.3), the association appeared to be due to increased oleic acid (OR = 1.7; 95 % CI: 0.9–3.1). We found no evidence that polymorphisms in NAT1 or NAT2 modify the association between NHL and meat-related mutagens. Our results provide further evidence that red meat consumption is associated with an increase in NHL risk, and new evidence that the specific components of meat, namely fat and meat-related mutagens, may be impacting NHL subtype risk differently.

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Acknowledgments

This research was supported by research grant 99B083 from the American Institute for Cancer Research and in part by grants CA94770 and CA100555 from the National Cancer Institute. The authors thank Mr. Martin Bast of the Nebraska Lymphoma Study Group for coordinating the case identification and for obtaining the physician consents of the study cases.

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Authors and Affiliations

  1. Department of Health Studies, University of Chicago, 5841 South Maryland Avenue, N101B, Chicago, IL, 60637, USA

    Briseis Aschebrook-Kilfoy, Nicholas J. Ollberding & Brian C.-H. Chiu

  2. Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA

    Carol Kolar & Terence A. Lawson

  3. Division of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA

    Sonali M. Smith

  4. Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA

    Dennis D. Weisenburger

  5. University of Chicago Comprehensive Cancer Center, Chicago, IL, USA

    Brian C.-H. Chiu

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  1. Briseis Aschebrook-Kilfoy
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  3. Carol Kolar
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Correspondence to Briseis Aschebrook-Kilfoy.

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Aschebrook-Kilfoy, B., Ollberding, N.J., Kolar, C. et al. Meat intake and risk of non-Hodgkin lymphoma. Cancer Causes Control 23, 1681–1692 (2012). https://doi.org/10.1007/s10552-012-0047-2

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  • DOI: https://doi.org/10.1007/s10552-012-0047-2

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