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Hypofractionated stereotactic radiotherapy and continuous low-dose temozolomide in patients with recurrent or progressive malignant gliomas

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Abstract

To evaluate the efficacy of reirradiation and systemic chemotherapy as salvage treatment in patients with recurrent malignant glioma. Between May 2006 and December 2011, 54 patients with recurrent malignant glioma received hypofractionated stereotactic radiotherapy (HSRT) plus systemic therapy at University of Rome Sapienza, Sant’ Andrea Hospital. All patients had Karnofsky performance score ≥60 and were previously treated with standard conformal RT (60 Gy) with concomitant and adjuvant temozolomide (TMZ) up to 12 cycles. Thirty-eight patients had a GBM and 16 patients had a grade 3 glioma. The median time interval between primary RT and reirradiation was 15.5 months. At the time of recurrence all patients received HSRT (30 Gy in 6-Gy fractions) plus concomitant TMZ (75 mg/m2/day) followed by continuous TMZ at 50 mg/m2 everyday up to 1 year or until progression. Median overall survival after HSRT was 12.4 months, and the 12- and 24-month survival rates were 53 and 16 %, respectively. The median progression-free survival (PFS) was 6 months, and the 12- and 24-month PFS rates were 24 and 10 %, respectively. KPS >70 (P = 0.04) and grade 3 glioma were independent favourable prognostic factors for survival. In general chemoradiation regimen was well tolerated with relatively low treatment-related toxicity. HSRT plus concomitant TMZ followed by continuous dose-intense TMZ is a feasible treatment option associated with survival benefits and low risk of complications in selected patients with recurrent malignant glioma. The potential advantages of combined chemoradiation schedules in patients with recurrent malignant gliomas need to be explored in future studies.

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Acknowledgments

We thank Dr Alessandro Bozzao and Dr Andrea Romano, neuroradiologists at Sant’ Andrea Hospital for reviewing all MRI scans. We thank the nursing staff and radiographers of Radiation Oncology and Physics Departments at Sant’ Andrea for their valuable assistance during the study. Finally, we wish to thank all the patients who participated in this study.

Conflict of interest

The authors declare there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, Sant’ Andrea Hospital, University Sapienza, Rome, Italy

    Giuseppe Minniti, Claudia Scaringi, Vitaliana De Sanctis, Teresa Falco & Riccardo Maurizi Enrici

  2. Department of Neurological Sciences, IRCCS Neuromed, Pozzilli (IS), Italy

    Giuseppe Minniti, Gaetano Lanzetta & Vincenzo esposito

  3. Department of Pathology, Sant’ Andrea Hospital, University Sapienza, Rome, Italy

    Domenica Di Stefano

  4. Department of Radiotherapy Oncology, Sant’ Andrea Hospital, Via di Grottarossa 1035, 00189, Rome, Italy

    Giuseppe Minniti

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  1. Giuseppe Minniti
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Correspondence to Giuseppe Minniti.

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Minniti, G., Scaringi, C., De Sanctis, V. et al. Hypofractionated stereotactic radiotherapy and continuous low-dose temozolomide in patients with recurrent or progressive malignant gliomas. J Neurooncol 111, 187–194 (2013). https://doi.org/10.1007/s11060-012-0999-9

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