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Role of Oral Pre-exposure Prophylaxis (PrEP) in Current and Future HIV Prevention Strategies

  • Behavioral-Bio-Medical Interface (JL Brown and RJ DiClemente, Section Editors)
  • Published:
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Abstract

Treatment as prevention is expected to have a major role in reducing HIV incidence, but other prevention interventions will also be required to bring the epidemic under control, particularly among key populations. One or more forms of pre-exposure prophylaxis (PrEP) will likely play a critical role. Oral PrEP with emtricitabine-tenofovir (Truvada®) is currently available in the US and some other countries, but uptake has been slow. We review the concerns that have contributed to this slow uptake and discuss current and future research in this critical area of HIV prevention research.

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Acknowledgments

The authors wish to thank Keith Rawlings and Gilead Sciences for providing Table 1 data and the members of the DAIDS/NIAID PrEP Working Group for their contributions to the original development of Table 2. Special thanks to Lester Freeman (HJF-DAIDS Contractor) for his excellent assistance in preparing and submitting the manuscript.

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Conflict of Interest

David N. Burns, Cynthia Grossman, Jim Turpin, Vanessa Elharrar, and Fulvia Veronese declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5601 Fishers Lane, MSC 9831, Bethesda, MD, 20892, USA

    David N. Burns, Jim Turpin, Vanessa Elharrar & Fulvia Veronese

  2. Division of AIDS Research, National Institute of Mental Health, National Institutes of Health, 5601 Fishers Lane, Room 9G19, MSC 9831, Bethesda, MD, 20892, USA

    Cynthia Grossman

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Burns, D.N., Grossman, C., Turpin, J. et al. Role of Oral Pre-exposure Prophylaxis (PrEP) in Current and Future HIV Prevention Strategies. Curr HIV/AIDS Rep 11, 393–403 (2014). https://doi.org/10.1007/s11904-014-0234-8

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