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Clinical efficacy of Gossypium herbaceum L. seeds in perceived insufficient milk (PIM) supply: A randomized single-blind placebo-controlled study

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Abstract

To evaluate the efficacy of Gossypium herbaceum L. in perceived insufficient milk (PIM) supply. In this single-blind, placebo-controlled, randomized clinical trial, test group (n = 30), received kernel of Gossypium herbaceum, 10 g (powder filled in the capsules) orally in three divided doses for 1 month, whereas the placebo group (n = 15), received wheat flour. The primary outcome measures were reduction in volume of supplementary feeds, and weight gain of the baby. The secondary outcome measures were improvement in subjective satisfaction of the mothers regarding the well being and happiness of babies, feeling fullness in the breast, contra lateral ejection of the milk, and mother’s observation in increase of breast milk. These parameters were rated on a graded scale ranging from 1 to 5 (1 denoting unsatisfactory and 5 representing highly satisfactory). The data was analyzed by using Student’s t test, Chi-square or Fisher exact test to find the significance (P < 0.05) of the study parameters. In the test group, 21(70 %), 7(23.33 %) and 2(6.67 %) mothers had complete relactation, partial relactation and no response correspondingly, whereas in the control group 4(26.67 %) mothers had complete relactation, and 11(73.33 %) mothers had no response. The volume of supplementary feeds to the infant in the test group was significantly reduced to 40 ± 75.88 ml after treatment from the baseline of the test group (291.66 ± 70.50 ml; P < 0.001) and placebo (226.66 ± 149.84 ml; P < 0.008). The secondary outcome measures of the test group were significant statistically. This herb is efficacious, safe and cost effective in augmenting lactation in PIM supply.

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Authors and Affiliations

  1. Department of Amraze Niswan wa Ilmul Qabalat (Obstetrics and Gynecology), National Institute of Unani Medicine, Kottigepalya Magadi Main Road, Bangalore, 560091, Karnataka, India

    S. Manjula & Arshiya Sultana

  2. Department of Ilmus Saidla (Pharmacy), National Institute of Unani Medicine, Bangalore, Karnataka, India

    Khaleequr Rahman

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  1. S. Manjula
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  2. Arshiya Sultana
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  3. Khaleequr Rahman
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Correspondence to Arshiya Sultana.

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Manjula, S., Sultana, A. & Rahman, K. Clinical efficacy of Gossypium herbaceum L. seeds in perceived insufficient milk (PIM) supply: A randomized single-blind placebo-controlled study. Orient Pharm Exp Med 14, 77–85 (2014). https://doi.org/10.1007/s13596-013-0121-7

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