The inheritance of left ventricular structure and function assessed by imaging and Doppler echocardiography☆
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Cited by (64)
Intrafamilial aggregation and heritability of tissue Doppler indexes of left ventricular diastolic function in a group of African descent
2016, Journal of the American Society of HypertensionCitation Excerpt :However, the factors that determine cardiac diastolic function have not been completely elucidated. Several studies have demonstrated heritability or intrafamilial aggregation of various aspects of left ventricular (LV) diastolic function identified from transmitral blood flow velocity measurements.12–18 However, contemporary evaluation of LV DD also includes E/velocity of myocardial tissue lengthening at the mitral annulus (Ea or eʹ) (E/eʹ), an index of filling pressures used to identify moderate-to-severe DD and which is independently associated with the development of heart failure with a preserved EF.19,20
Family history of cardiovascular disease and offspring echocardiographic left ventricular structure and function: The Asklepios study
2013, Journal of the American Society of EchocardiographyCitation Excerpt :This is in agreement with Jin et al.,2 who demonstrated moderate heritability for LV mass (multivariate-adjusted heritability of 23%). Bielen et al.5 showed a significant genetic contribution to myocardial wall thickness but no influence of heritability on LV internal diameters, for which environmental effects were shown. Overall, small to moderate heritability has been shown for LV structure.
Is a shorter atrioventricular septal length an intermediate phenotype in the spectrum of nonsyndromic atrioventricular septal defects?
2012, Journal of the American Society of EchocardiographyCitation Excerpt :Applying these cutoffs to the entire study population, this would include 5.7% of parents and 4.5% of siblings, all of whom were from case families. The heritability of the echocardiographic measurements of selected cardiac structures has been previously examined.35-44 For example, heritability has been estimated to be 0.96 for aortic root measurements, 0.72 for sinotubular junction measurements, and 0.57 for aortic valve annular measurements in first-degree relatives of children with left ventricular outflow tract obstructive malformations.44
The role of genetic research in sport
2011, Science and SportsCitation Excerpt :One of the main directions was the functioning of the circulatory and respiratory systems. Research on male twins showed that, except for left ventricular internal diameter, all heart structures were significantly influenced by genetic factors, with heritability levels ranging from 29 to 68% [21]. Other cardiac structures and functions (i.e. heart rate, peak aortic flow velocity, stroke distance and minute distance (understood as the distance that can be run in one minute) also showed a significant genetic effect, which ranged from about 50 to 60% [3].
Hypertension and Valvular Heart Disease
2008, Diastology: Clinical Approach to Diastolic Heart FailureGenetic influence on left ventricular structure and function: A Korean twin and family study
2015, Twin Research and Human Genetics
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Supported by grants from the Belgian National Research Council (NFWO) and the National Lottery of Belgium.