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Cited by (49)
Diagnostic Pathology: Hepatobiliary and Pancreas
2017, Diagnostic Pathology: Hepatobiliary and PancreasArsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes
2012, International ImmunopharmacologyCitation Excerpt :We now demonstrate that arsenite decreases the activity of promoters controlled by PXR/RXRα (Fig. 1A) and RAR/RXRα (Fig. 1B). Crosstalk between PXR/RXRα and other transcription factors may explain the many phenotypes of arsenite toxicity [3–8,17]. PXR/RXRα interacts with the inflammatory pathway NFκB and suppresses the inflammatory response [19,20].
Arsenic concentration in selected soils around Abeokuta, southwestern Nigeria
2007, Trace Metals and other Contaminants in the EnvironmentCitation Excerpt :According to Centeno et al. (2002), epidemiological and clinical studies reported in the medical literature have confirmed the role of As in the introduction of cancers of the skin, which include keratosis, squamous cell carcinoma and basal cell carcinoma. Apart from these skin lesions, other internal lesions that have been epidemiologically linked with As exposure include angiosarcoma of the liver, lung cancer and bladder cancer (Tsai et al., 1999), gastrointestinal manifestations which include noncirrhotic portal hypertension (Nevens et al., 1990), liver angiosarcoma (Neshiwat et al., 1993) and hepatic or splenic enlargement and hepatocellular carcinoma (Centeno et al., 2002). Arsenic (As) is widely distributed in nature and is one of the several elements that are generally toxic to biological species (Levinson, 1974).
Hepatoportal sclerosis and liver angiosarcoma: An infrequent association with a possible common etiology
2005, Gastroenterologia y HepatologiaMalignant primary tumours of the liver other than hepatocellular carcinoma
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2005, Transplantation of the Liver