Detection and measurement by high-performance liquid chromatography of malondialdehyde crosslinks in DNA
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Cited by (40)
What is the DNA repair defect underlying Fanconi anemia?
2015, Current Opinion in Cell BiologyCitation Excerpt :Acetaldehyde is a byproduct of ethanol oxidation and an intermediate of carbohydrate metabolism [95], and it forms ICLs, mainly by reacting with guanines (Figure 3b) [96–98]. Other reactive aldehydes including 4-hydroxynonenal (4-HNE), acrolein, malondialdehyde and crotonaldehyde are produced through lipid peroxidation [88], and most of these agents are able to form ICLs [98–102]. Despite evidence that reactive aldehydes induce ICLs in the test tube, for many years there was no evidence to suggest they underlie the etiology of FA.
The differences between ICL repair during and outside of S phase
2013, Trends in Biochemical SciencesCitation Excerpt :Interstrand crosslinks (ICLs) are cytotoxic DNA lesions that are induced in DNA from exogenous sources and may also arise endogenously. It has been suggested that malondialdehyde, a product of lipid peroxidation, can generate adducts in DNA that become rearranged to form ICLs endogenously [1,2]. ICLs are covalent linkages between the opposing stands of the DNA helix and are particularly deleterious to cells because they block the processes of transcription, replication, and other DNA transactions that require unwinding of the DNA helix.
A novel link to base excision repair?
2010, Trends in Biochemical SciencesReactions of lipid-derived malondialdehyde with collagen
1999, Journal of Biological ChemistryEffects of ageing on nuclear DNA integrity and metabolism in mussel cells (Mytilus edulis L.)
1999, International Journal of Biochemistry and Cell BiologyThe alkaline single cell gel electrophoresis: A new test for assessing DNA single strand breaks in Neurospora crassa
1998, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis