Lysosome-associated membrane proteins: Characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells☆
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2019, Fish and Shellfish ImmunologyCitation Excerpt :Lysosomes require many special proteins to maintain their role in cells. The lysosomal membrane contains up to 100 LMPs, of which about 25 have been studied and all of these may be critical to the biosynthesis and function of lysosomes [57,58]. Lysosomal metabolic pathways were involved in cell apoptosis.
Construction and evaluation of DNA vaccine encoding Hantavirus glycoprotein N-terminal fused with lysosome-associated membrane protein
2015, VaccineCitation Excerpt :DNA vaccines show more promises [19]; however, conventional DNA constructs encode endogenous antigens forming the peptide/major histocompatibility complex (MHC) I complexes, and only initiate CD8+ cytotoxic T-cell (CTL) activation [20]. Lysosomal-associated membrane protein 1 (LAMP1) [21,22], as an intrinsic element of lysosome, was desired for antigens directed to vesicular lysosomal/endosomal sites, where MHC II presentation occurred [20]. After antigens being processed by MHC II pathway, CD4+ T cells, which are critical for cellular, humoral and long-term immune responses, can be effectively primed [23–28].
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2013, Progress in Histochemistry and CytochemistryCitation Excerpt :However, the overlapping of ED1 and ED2 reaction has never been formally proven using the double immunohistochemical staining. In addition, being rich in lysosomes, these cells are positive for lysosome-associated membrane protein 1 (LAMP-1) (Fig. 3c) (Chen et al., 1985). It is known that the large majority of thymocytes (95−98%) in the thymus die through apoptosis being incapable to pass through the process of positive selection (Scollay et al., 1984).
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This research was supported by Public Health Service Grant RO1 GM31168.
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J.W.C. is the recipient of Medical Scientist Training Program Grant 5 T32 GM07309.