Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells
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2022, Translational ResearchCitation Excerpt :According to recent studies, MCP-1 appears to play a major role in the formation of intimal hyperplasia and restenosis because it aids in monocyte, macrophage, and smooth muscle cell (SMC) proliferation, migration and regulates the functional switch of SMCs from the contractile to the synthetic phenotype.15,16 Upon exposure to inflammatory stimuli, endothelial cells, smooth muscle cells, and fibroblasts can express MCP-1.17,18 MCP-1 binds to chemokine receptor type 2 (CCR2).19
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2014, Molecular and Cellular EndocrinologyCitation Excerpt :The level of CCL2 is correlated with accumulation of tumor-associated macrophages in the primary breast cancer, and is a significant indicator of early relapse (Ueno et al., 2000; Saji et al., 2001). In solid tumors CCL2 can be produced by both cancer and stromal cells, including monocytes, fibroblasts, and endothelial cells (Strieter et al., 1989; Lazennec and Richmond, 2010), and its expression in each compartment is dynamically regulated by crosstalk between the tumor and the niche. For example, increased expression of CCL2 is detected in bone marrow MSCs following stimulation by leukemia cells resulting in enhanced cancer-promoting capacity of MSCs (de Vasconcellos et al., 2011).
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2013, Cancer LettersCitation Excerpt :In addition, CAFs synthesize increased amount of growth factors such as hepatocyte growth factors (HGF), insulin-like growth factors (IGF), nerve growth factors (NGF), Wnt1, epidermal growth factor (EGF) and fibroblasts growth factors 2 (FGF2) inducing proliferative signals within adjacent epithelial cells [155]. CAFs are also able to modulate the immune response due to the secretion of the pro-inflammatory cytokines interleukin-1,6,8 and TNFα as well as the chemokine monocyte chemotactic protein 1 (MCP1/CCL2) [151,156–159]. The origin of activated fibroblasts are not completely clarified.
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