Biochemical and Biophysical Research Communications
Astrocytes possess prostaglandin F2α receptors coupled to phospholipase C
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Cited by (31)
FP prostanoid receptor
2007, xPharm: The Comprehensive Pharmacology ReferenceLatanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinase
2006, Experimental Eye ResearchCitation Excerpt :As mentioned earlier, latanoprost is a PGF2α derivative and has the high affinity of binding to FP receptor (Sharif et al., 2002, 2003). Evidence is mounting that PGF2α and FP receptor system has an anti-apoptotic ability in the cortical neurons as well as kidney cells, cardiomyocytes, and hen granulose cells (Cazevieille et al., 1994; Manchanda et al., 2001; Morissette et al., 2003; Nishimura et al., 2004) probably through the phosphoinositide-mediated intracellular calcium mobilization (Kitanaka et al., 1991; Chen et al., 1997; Griffin et al., 1998; Kelly et al., 2003; Ansari et al., 2004). PGF2α is known to activate the p44/p42 MAPK pathway in bovine (Ansari et al., 2004) and cat iris sphincter muscle cells (Husain and Jafri, 2002).
Hydrogen peroxide-induced thymidine incorporation into cultured rat astrocytes
2006, Journal of Pharmacological SciencesGFAP phosphorylation studied in digitonin-permeabilized astrocytes: Standardization of conditions
2000, Brain ResearchCitation Excerpt :This process allows access to intracellular phosphorylating systems and preserves compartments and biochemical processes within the cell and is particularly applicable to the study of insoluble cytoskeletal proteins. Other aspects of protein phosphorylation have been investigated in digitonin-permeabilized neural cells, for example in adrenal chromaffin cells to study tyrosine hydroxylase phosphorylation [4, 9, 27]and in astrocytes where digitonin-permeabilization has been used to investigate intracellular pools of Ca2+[22, 23], internal stores of metabolites [14, 33]and phosphoinositide hydrolysis [17, 28]. Since the efficiency of permeabilization varies in different cell types [31]we first investigated conditions for permeabilizing astrocytes with digitonin.
Digitonin-permeabilization of astrocytes in culture monitored by trypan blue exclusion and loss of S100B by ELISA
2000, Brain Research ProtocolsLocalization of the prostaglandin F<inf>2</inf> alpha receptor in rat tissues
1997, Prostaglandins Leukotrienes and Essential Fatty Acids