Elsevier

Biochemical Pharmacology

Volume 23, Issue 6, 15 March 1974, Pages 1033-1040
Biochemical Pharmacology

Biochemical basis of hereditary resistance to warfarin in the rat

https://doi.org/10.1016/0006-2952(74)90002-1Get rights and content

Abstract

The influence of warfarin on prothrombin formation and the regeneration of vitamin K from vitamin K-2,3-epoxide was examined in control and warfarin-resistant rats. The epoxide reductase from liver of resistant rats was inhibited by warfarin less than the reductase from control animals. The concentration of warfarin required to inhibit the reductase in vitro was similar in control and resistant rats to the concentration of warfarin in vivo during inhibition of prothrombin formation. These results are interpreted as evidence of the biochemical basis for hereditary resistance to warfarin in the rat.

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