Relationships between brain ct scan findings and cortisol in psychotic and nonpsychotic depressed patients

doi:10.1016/0006-3223(89)90081-4

Biological Psychiatry

Volume 26, Issue 6, October 1989, Pages 565-575

https://doi.org/10.1016/0006-3223(89)90081-4 Get rights and content

Abstract

In this report, data are presented on pre- and postdexamethasone cortisol levels, neuropsychological testing, and computed tomography (CT) scan findings in 30 depressed patients (15 psychotic and 15 nonpsychotic). Particularly significant findings were observed when data from the unipolar subgroup (n = 22) were analyzed separately. Unipolar psychotic depressed patients had significantly larger (p < 0.05) anterior pole and cella media ventricle-to-brain ratios (VBRs) and significantly greater (p < 0.05) left and right inferior parietal brain “atrophy” than nonpsychotic depressed patients. Higher rates of Dexamethasone Suppression Test (DST) nonsuppression were observed in psychotic depressed patients and in patients with larger cella VBRs. Inferior parietal brain atrophv and large VBRs were also associated with greater cognitive impairment on psychometric testing. Implications of these findings are discussed.

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^☆: Supported in part by NIMH Grant MH-38671, a grant from the Poitras Charitable Foundation, and by a grant from the Ruth Rothstein Greif Fund.

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Relationships between brain ct scan findings and cortisol in psychotic and nonpsychotic depressed patients☆

Abstract

Biol Psychiatry

Neurobiol Aging

Brain Res

Lancet

Psychiatry Res

Lancet

Psychiatry Res

J Psychiatr Res

Life Sci

Psychiatry Res

J Psychiatr Res

Biol Psychiatry

Psychiatry Res

Diagnostic and Statistical Manual of Mental Disorders

The Dexamethasone Suppression Test: An overview of its current status in psychiatry

Am J Psychiatry

Changes in size of normal lateral ventricles during aging determined by computerized tomography

Neurology

Postnatal development of aminergic projections to frontal cortex: Effects of cortical lesions

J Neurosci Res

Urinary MHPG in subgroups of depressed patients and normal controls

Neuropsychobiology

Steroids and apparant cerebral atrophy on computed tomography scans

J Comput Assist Tomogr

Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans

Science

A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility

Arch Gen Psychiatry

The Dexamethasone Suppression Test in the clinical setting

Am J Psychiatry

Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: Measurement by the standardized Luria-Nebraska Neuropsychological Battery

Arch Gen Psychiatry

Effects of the noradrenaline neurotoxin DSP4 on monoamine neurons and their transmitter turnover in rat CNS

J Neurol Transm

A rating scale for depression

J Neurol Neurosurg Psychiatry