ArticleVitamin C status in chronic schizophrenia☆
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2019, Pharmacological ResearchCitation Excerpt :Relatively high doses of AA, for example, may exert a DA antagonist action, whereas low doses can potentiate amphetamine reward [17]. Moreover, the notion of a link between schizophrenia and DA itself remains tenuous and is well beyond any further speculation of a possible link to AA [25,161,162]. Neuromodulation of DA neurotransmission may better support suggestions of AA applications for autism [163], dyskinesia [164,165], catalepsy [166], and obstructive sleep apnea [167].
Implications for reactive oxygen species in schizophrenia pathogenesis
2016, Schizophrenia ResearchAntioxidants as potential therapeutics for neuropsychiatric disorders
2013, Progress in Neuro-Psychopharmacology and Biological PsychiatryFree radicals, antioxidant defense systems, and schizophrenia
2013, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :The levels of uric acid, albumin, and bilirubin have been reported to be significantly lower in the first-episode schizophrenic patients, and the lower antioxidant levels were independent of smoking status (Reddy et al., 2003; Yao et al., 1998c, 2000), which implicated the impaired antioxidant defense as an early pathophysiological change in schizophrenia and this change was not a sequela of drug effects, chronic disease, or smoking. In addition, serum levels of α-tocopherol (McCreadie et al., 1995) and plasma levels of ascorbic acid (Suboticanec et al., 1990) have also been reported to be decreased in schizophrenic patients. Recently, a novel oxidative stress marker thioredoxin (TRX), a small ubiquitous protein containing a redox-active disulfide/dithiol, has been investigated in first-episode and chronic patients with schizophrenia (Zhang et al., 2009).
Meta-analysis of oxidative stress in schizophrenia
2013, Biological Psychiatry
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This research was supported in part by Scientific Council of Croatia, and Foundation for Nutritional Advancement, Washington.