Elsevier

Biological Psychiatry

Volume 28, Issue 6, 15 September 1990, Pages 488-494
Biological Psychiatry

Computerized EEG in Schizophrenic patients

https://doi.org/10.1016/0006-3223(90)90482-HGet rights and content

Abstract

We undertook a study of electroencephalograms (EEGs) in 30 right-handed, untreated patients (27.3 ± 10.0 years; hebephrenic, 16; paranoid, 12; residual, 2) who fulfilled ICD-9 criteria for schizophrenia and compared them with sex- and age-matched controls by using the percentage of power in six EEG frequency bands calculated as a fraction of total power. T-statistic significance probability mapping (t-SPM) showed that, compared with normal controls, schizophrenics had more slow activity (delta, theta, and alpha 1) in the parieto-occipital regions, and more fast activity (beta 1) in the occipital regions. In contrast, alpha 2 activity decreased strikingly in the occipital regions and this decreased activity extended over much of the head. These findings were thought to indicate both cerebral hypofunction and excitability in acute untreated schizophrenia.

References (62)

  • J.L. Cadet et al.

    Behavioral and biochemical effects of intranigral injection of phospholipase-A2

    Biol Psychiatry

    (1989)
  • J. Chang et al.

    Phospholipase A2: Function and pharmacological regulation

    Biochem Pharmacol

    (1987)
  • L. Demisch et al.

    Incorporation of 14C-arachidonic acid into platelet phospholipids of untreated patients with schizophreniform or schizophrenic disorders

    Psychiatry Res

    (1987)
  • A.N. Erin et al.

    Stabilization of synaptic membranes by α-tocopherol against the damaging action of phospholipases. Possible mechanism of biological action of vitamin E.

    Brain Res

    (1986)
  • J.E. Fletcher et al.

    Effects of beta-bungarotoxin and naja naja atra snake venom phospholipase A2 on acetylcholine release and choline uptake in synaptosomes

    Toxicon

    (1986)
  • W.F. Gattaz et al.

    HLA antigens and schizophrenia: A pool of two studies

    Psychiatry Res

    (1981)
  • W.F. Gattaz et al.

    Increased plasma phospholipase-A2 activity in schizophrenic patients: Reduction after neuroleptic therapy

    Biol Psychiatry

    (1987)
  • M.S. Keshavan et al.

    In vivo 31P nuclear magnetic resonance (NMR) spectroscopy of the frontal lobe metabolism in neuroleptic-naive first episode psychoses: Preliminary studies (Abstract)

    Schizophr Res

    (1989)
  • A.Y. Sun

    Involvement of phospholipase A2 in norepinephrine release from synaptosomes isolated from rat cerebral cortex

    Neurochem Int

    (1985)
  • K. Taniguchi et al.

    Effects of various drugs on superoxide generation, arachidonic acid release and phospholipase A2 in polymorphonuclear leukocytes

    Jpn J Pharmacol

    (1988)
  • H. Van den Bosch

    Intracellular phospholipases A

    Biochim Biophys Acta

    (1980)
  • R. Abrams et al.

    Differential EEG patterns in affective disorder and schizophrenia

    Arch Gen Psychiatry

    (1979)
  • H. Berger

    Über das Electrenkephalogramm des Menschen. X II

    Arch Psychiatr Nervenkr

    (1937)
  • M.S. Buchsbaum et al.

    Cerebral glucography with positron topography: Use in normal subjects and in patients with schizophrenia

    Arch Gen Psychiatry

    (1982)
  • R.W. Coger et al.

    Electroencephalographic similarities between chronic alcoholics and chronic non-paranoid schizophrenics

    Arch Gen Psychiatry

    (1979)
  • W.J. Dixon et al.

    BMDP statistical software

    (1981)
  • P. Etevenon et al.

    Differences in EEG asymmetry between patients with schizophrenia and normals assessed by Fourier analysis

  • P. Etevenon et al.

    Schizophrenia assessed by computerized EEG

    Adv Biol Psychiatry

    (1981)
  • G.W. Fenton et al.

    EEG spectral analysis in schizophrenia

    Br J Psychiatry

    (1980)
  • P. Flor-Henry

    Lateralized temporal-limbic dysfunction and psychopathology

    Ann NY Acad Sci

    (1976)
  • P. Flor-Henry et al.

    Neurophysiological studies of schizophrenia, mania and depression

  • Cited by (95)

    • Cellular and circuit models of increased resting-state network gamma activity in schizophrenia

      2016, Neuroscience
      Citation Excerpt :

      For example, in a large (n = 100/group) clinical study, SCZ patients demonstrated increased 24–33-Hz activity (Itil et al., 1972) which was stable over three months (Itil et al., 1974). However, three did report elevations in high beta (20–30 Hz) power, interpreted as reflecting “cortical noise” (Kissler et al., 2000; Krishnan et al., 2005; Brockhaus-Dumke et al., 2008), although another did not (Miyauchi et al., 1990). A larger EEG study observed increased 20–50-Hz power in SCZ subjects and their relatives (Venables et al., 2009) and another group found broad-band increases of baseline activity at all frequencies (Winterer et al., 2004), although a similar MEG study employing source-space projections found opposite results (Rutter et al., 2009).

    • What does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder

      2016, International Journal of Psychophysiology
      Citation Excerpt :

      Later, several authors stated that EEG was not noise and that selectively synchronized alpha oscillations in the mammalian and human brain are part of the fundamental functional signaling of the central nervous system (Başar, 1980; Lehmann, 1989; Nunez et al., 2001). Decrease of spontaneous alpha activity is one of the common EEG parameters reported in Alzheimer's disease, bipolar disorder and schizophrenia (Itil et al., 1972, 1974; Iacono, 1982; Miyauchi et al., 1990; Sponheim et al., 1994, 2000; Alfimova and Uvarova, 2008, see Fig. 1 for a graphical summary). Since the cause and pathology behind these three diseases differ considerably, the generalization of this finding needs further exploration.

    View all citing articles on Scopus
    View full text