Elsevier

Biological Psychiatry

Volume 30, Issue 11, 1 December 1991, Pages 1131-1138
Biological Psychiatry

Reduced natural killer cell cytotoxicity in depression but not in schizophrenia

https://doi.org/10.1016/0006-3223(91)90183-MGet rights and content

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  • Cited by (48)

    • Increased metabolic variability is associated with newly diagnosed depression: A nationwide cohort study

      2021, Journal of Affective Disorders
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      A prior study showed that weight fluctuation eventually decreased natural killer (NK) cell cytotoxicity and immunologic function (Shade et al., 2004). Decreased NK cell activity was also suggested as a biomarker for depression (Caldwell et al., 1991). Fourth, cholesterol metabolism can impact cellular membrane function.

    • Expression of inflammatory markers in a genetic rodent model of depression

      2015, Behavioural Brain Research
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      Lytic activity of natural killer cells, an essential component of the innate immune system and crucial to host defense against viral and bacterial infection, is significantly lower in FSL rats when compared to its control [12]. Noteworthy, reduced natural cytotoxicity has been seen in patients with major depression [13,14]. FSL rats are more susceptible to the induction of anaphylactic shock [15], and have deficiencies in antigen-specific antibody responses [16].

    • Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

      2013, Progress in Neuro-Psychopharmacology and Biological Psychiatry
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      The fact may point to a possible role of M1 macrophage activation in depression. However, as natural killer cell activities were found to be decreased repeatedly in depression (Caldwell et al., 1991; Evans et al., 1992; Irwin et al., 1990, 1992), the overall role of cell-mediated immunity in depression remains to be elucidated. Next, involvement of excitotoxicity in oxidative/nitrosative stress would be inspected.

    • Impaired monocyte activation in schizophrenia

      2012, Psychiatry Research
      Citation Excerpt :

      Functional aspects of the monocytic immune response in schizophrenia have rarely been studied, although functional deficits of innate immunity have been observed repeatedly. Early psychoneuroimmunological studies pointed to a reduced activity of natural killer (NK) cells – part of the innate immune response – in unmedicated (Urch et al., 1988; Abdeljaber et al., 1994; Vasil'eva et al., 2002) and medicated (Sasaki et al., 1994) schizophrenia patients, although the results are partly conflicting and may depend on several factors, including the type of antipsychotic medication (Caldwell et al., 1991; Yovel et al., 2000). Antipsychotic treatment was found to enhance NK cell function (Urch et al., 1988).

    • The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder

      2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry
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