Corticotropin releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells
Referencess (27)
- et al.
Cloning and structures of the human corticotrophin releasing factor-binding protein gene (CRHBP)
Genomics
(1993) Stress, corticotropin-releasing factor and behavior
Perspect. Behav. Med.
(1985)Central effects of CRF on metabolism and energy balance
Neurosci. Behav. Rev.
(1990)- et al.
Isolation of the human plasma corticotrophin-releasing factor-binding protein
J. Endocrinol.
(1989) - et al.
Corticotropin-releasing factor-binding protein: a putative peripheral and central modulator of the CRF family of neuropeptides
Ann. NY Acad. Sci.
(1993) - et al.
Corticotropin-releasing factor-binding protein in human brain: identification and characterization in Alzheimer's disease
- et al.
Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumathoid arthritis and osteoarthritis
J. Immunol.
(1993) - et al.
Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis
J. Clin. Invest.
(1992) - et al.
Simultaneous preparation of four cell type enriched glial cultures from rat cerebral cortex
J. Tiss. Cult. Methods
(1991) - et al.
Structure-related effects of CRF and CRF-derived peptides: dissociation of behavioral, endocrine and autonomic activity
Neuroendocinology
(1993)
Corticotropin-releasing factor (CRF): Central effects on mean arterial pressure and heart rate in rats
Endocrinology
Characterization of ameboid microglia isolated from developing mammalian brain
J. Neurosci.
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
Nature
Cited by (44)
Increased protein and mRNA expression of corticotropin-releasing factor (CRF), decreased CRF receptors and CRF binding protein in specific postmortem brain areas of teenage suicide subjects
2019, PsychoneuroendocrinologyCitation Excerpt :More broadly, the potential role for CRF-BP is for buffering and inhibiting or enhancing the effects of CRF family of peptides binding to CRF-R1 or CRF-R2 receptors. Neurons and glia of all CRF-related pathways in the brain express membranal CRF-BP, sometimes co-localized with CRF or CRF receptors (Behan et al., 1995b). Multiple roles for CRF-BP have been suggested.
Evidence for the role of corticotropin-releasing factor in major depressive disorder
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The effect is almost assuredly different depending on the tissue (Seasholtz et al., 2002), and CRFBP is highly expressed in brain, plasma, heart, lungs, intestines and placenta (Boorse and Denver, 2006; Potter et al., 1992; Vitoratos et al., 2006). Neurons and glia of all CRF related pathways in the brain express membranal CRFBP, sometimes directly colocalized with CRF or CRF receptors (Behan et al., 1995b; Potter et al., 1992). Following CRF receptor binding, which results in G protein phosphorylation and dissociation of α subunits (from βγ) to stimulate 2nd messenger cascades (see below), G protein related kinases (GRKs) rapidly desensitize the receptor via phosphorylation of serines and threonines in the third intracellular loop or C-terminus (Dautzenberg et al., 2002; Kelly et al., 2008; Kohout and Lefkowitz, 2003; Krasel et al., 2005; Moore et al., 2007).
Pituitary CRH-binding protein and stress in female mice
2015, Physiology and BehaviorCitation Excerpt :In contrast, the stress-mediated increases in pituitary CRH-BP protein levels in female mice were readily detected using the cross-linking assays. This result is consistent with previous studies showing increased CRH-BP protein in media from astrocyte or mixed neuronal cultures or total cellular protein from fetal amygdalar cultures after 12–24 h treatment with CRH or forskolin [29,30,54]. While pituitary CRH-BP mRNA levels returned to baseline by 4 h after restraint stress, female CRH-BP protein levels were significantly increased by 4 h and remained elevated at 6 h.
Evidence for TNFα action on excitatory and inhibitory neurotransmission in the central amygdala: A brain site influenced by stress
2013, Brain, Behavior, and Immunity