Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia
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Cited by (106)
Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease
2023, Seminars in Cell and Developmental BiologyCitation Excerpt :At the cellular level, numerous studies have characterised the relative vulnerability of GABAergic neurons in human AD brain (see Table 4). For example, early work in human post-mortem brain tissue from AD patients found evidence for reduced density and size of PV-positive interneurons in the frontal and temporal cortex [121]. However, this view was challenged by later findings reporting no change in the density of PV-positive neurons in AD-patient brain [122,123].
The interplay of neurovasculature and adult hippocampal neurogenesis
2021, Neuroscience LettersCitation Excerpt :Moreover, it has been suggested that Aβ plaques can cause loss of hippocampal interneurons [37] and tau can accumulate in GABAergic interneurons [157], causing deficits in adult hippocampal neurogenesis. Interestingly, PVIs have been identified as one of the interneurons to be impaired in both human AD studies [6] and AD mouse models [43,45,79]. Neuronal loss [2,37], intrinsic electrical properties [79,139], hypersynchrony [100], and altered neural network activity [100,139] have been reported for PVIs in various regions of the brain.
Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease
2019, Brain ResearchCitation Excerpt :Early studies found unaffected PV-positive neuron numbers in the temporal, visual and prefrontal cortex (Ferrer et al., 1991, 1993a; Hof et al., 1991; Leuba et al., 1998). Again, brain regions that are mainly affected by Aβ- and tau-pathology like the entorhinal cortex and hippocampus consistently showed decreased PV-positive neuron numbers (Arai et al., 1987; Brady and Mufson, 1997; Fonseca et al., 1993; Inaguma et al., 1992; Mikkonen et al., 1999; Satoh et al., 1991; Solodkin et al., 1996; Takahashi et al., 2010). Interestingly, impairments in neuronal network function like altered hippocampal oscillations have been shown to be associated with deficits in PV-positive inhibitory neuron function in AD and mouse models of AD (Verret et al., 2012); Chaper 2).
Immunoreactivity of calcium binding protein secretagogin in the human hippocampus is restricted to pyramidal neurons
2007, Experimental GerontologyThe dentate gyrus in Alzheimer's disease
2007, Progress in Brain ResearchCitation Excerpt :The latter study is flawed by the fact that the total number of cases and immunoreactive cells is low. In other brain areas, a reduction is found, ranging between 20 and 72%, depending on brain region and layer (Arai et al., 1987; Solodkin et al., 1996; Mikkonen et al., 1999). Again, others differ when reporting no loss (Hof et al., 1991; Fonseca et al., 1993; Sampson et al., 1997; Leuba et al., 1998).
This work was supported by the research grant to H.A. from the Mental Health Foundation, U.K. and the Swiss National Science Foundation (3.147.0.85) to C.W.H.A. is a Visiting Research Fellow from the Psychiatric Research Institute of Tokyo, Tokyo 156, Japan.