Elsevier

Brain Research

Volume 463, Issue 1, 25 October 1988, Pages 148-152
Brain Research

APV, an N-methyl-d-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats

https://doi.org/10.1016/0006-8993(88)90538-0Get rights and content

Abstract

2-Aminophosphonovaleric acid (APV), an N-methyl-d-aspartate (NMDA) receptor antagonist, was infused into the lateral ventricles of behaving rats. A 10 or 20 μg dose of APV attenuated the hippocampal θ rhythm and the θ phase-shift at the apical dendrites of hippocampal CA1 region. A selective suppression of the atropine-sensitive θ rhythm was suggested.

References (18)

There are more references available in the full text version of this article.

Cited by (85)

  • Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats

    2022, Neurobiology of Disease
    Citation Excerpt :

    This is in agreement with previous studies that, despite variations in dosage, administration method, and the behavior of rats during recording, studies have consistently illustrated the attenuating effect of NMDA antagonists on mPFC and hippocampal theta power.( Kiss et al., 2013; Kittelberger et al., 2012; Lazarewicz et al., 2010; Leung and Desborough, 1988; Puma et al., 1996; Saunders et al., 2012) and HFO power.( Hudson et al., 2020; Ye et al., 2018).

  • Is hippocampal theta frequency related to individual and sex differences in anxiety-like behaviour? An analysis in male and female Long-Evans rats

    2019, Behavioural Brain Research
    Citation Excerpt :

    However, there are a number of additional intrinsic and neuromodulatory inputs to the hippocampus that modulate theta properties. For example, pharmacological manipulations of cholinergic, serotonergic, dopaminergic, and glutamatergic transmission have all been shown to alter theta activity in rats [3,9,21,38,39]. However, many of these manipulations affect both the power and frequency of theta, in contrast to the frequency-selective effect elicited by anxiolytics.

  • Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats

    2017, Journal of Psychiatric Research
    Citation Excerpt :

    No change was observed in the average spectral power of hippocampal theta-band after KET administration. Regarding theta-band oscillations and KET administration, contradictory results are found in the literature, since reductions (Leung and Desborough, 1988; Dimpfel and Spüler, 1990; Lazarewicz et al., 2010; Kittelberger et al., 2012) and increases (Mattia and Moreton, 1986; Páleníček et al., 2011) were observed. These conflicting results are probably due to differences in the experimental protocols used in these studies, i.e. dose, animal species, time and routes of administration.

View all citing articles on Scopus

The research was supported by grants from the Natural Sciences and Engineering Research Council and the Medical Research Council.

*

We thank the comments of Dr. C.H. Vanderwold and the excellent typing of Bev Hughes.

View full text