APV, an N-methyl-d-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats
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Cited by (85)
Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats
2022, Neurobiology of DiseaseCitation Excerpt :This is in agreement with previous studies that, despite variations in dosage, administration method, and the behavior of rats during recording, studies have consistently illustrated the attenuating effect of NMDA antagonists on mPFC and hippocampal theta power.( Kiss et al., 2013; Kittelberger et al., 2012; Lazarewicz et al., 2010; Leung and Desborough, 1988; Puma et al., 1996; Saunders et al., 2012) and HFO power.( Hudson et al., 2020; Ye et al., 2018).
Is hippocampal theta frequency related to individual and sex differences in anxiety-like behaviour? An analysis in male and female Long-Evans rats
2019, Behavioural Brain ResearchCitation Excerpt :However, there are a number of additional intrinsic and neuromodulatory inputs to the hippocampus that modulate theta properties. For example, pharmacological manipulations of cholinergic, serotonergic, dopaminergic, and glutamatergic transmission have all been shown to alter theta activity in rats [3,9,21,38,39]. However, many of these manipulations affect both the power and frequency of theta, in contrast to the frequency-selective effect elicited by anxiolytics.
Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats
2017, Journal of Psychiatric ResearchCitation Excerpt :No change was observed in the average spectral power of hippocampal theta-band after KET administration. Regarding theta-band oscillations and KET administration, contradictory results are found in the literature, since reductions (Leung and Desborough, 1988; Dimpfel and Spüler, 1990; Lazarewicz et al., 2010; Kittelberger et al., 2012) and increases (Mattia and Moreton, 1986; Páleníček et al., 2011) were observed. These conflicting results are probably due to differences in the experimental protocols used in these studies, i.e. dose, animal species, time and routes of administration.
The research was supported by grants from the Natural Sciences and Engineering Research Council and the Medical Research Council.
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We thank the comments of Dr. C.H. Vanderwold and the excellent typing of Bev Hughes.