Responses of monkey midbrain dopamine neurons during delayed alternation performance
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2020, Cell ReportsCitation Excerpt :DA neurons with cell bodies in the ventral tegmental area (VTA-DA) and substantia nigra (SNc-DA) project to the striatum, PFC, and other forebrain regions. These neurons, which are thought to provide the major source of DA to their forebrain targets, are known to respond transiently to unexpected rewards and reward-predicting cues (Bayer and Glimcher, 2005; Cohen et al., 2012; Ellwood et al., 2017; Ljungberg et al., 1991; Parker et al., 2016; Roesch et al., 2007; Schultz, 1986, 1998; Schultz et al., 1993). This signal has been interpreted as a reward prediction error, which is thought to support reinforcement learning (Chang et al., 2016; Parker et al., 2016; Steinberg et al., 2013).
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2019, Progress in NeurobiologyCitation Excerpt :We found as expected that repeated cue-reward pairing was associated with transfer of the dopamine response from the reward to the cue in the course of several sessions. The cue and reward responses are consistent with the activation of midbrain dopamine cells observed in primates and rats (Cohen et al., 2012; Ljungberg et al., 1991, 1992; Pan et al., 2005; Schultz, 1986). The time course of the average dopamine response following the cue was relatively prolonged, consistent with many previous studies that have found similarly prolonged elevation in the level of dopamine between cue and reward in a number of different paradigms (Flagel et al., 2011; Howe et al., 2013; Patriarchi et al., 2018; Phillips et al., 2003; Roitman et al., 2004).
Dopamine and Cognitive Control in Prefrontal Cortex
2019, Trends in Cognitive SciencesCitation Excerpt :The phasic discharges lead to a sudden and brief release of dopamine that is ideally suited to explain the gating mechanism discussed in the previous section. However, during the delay, for instance between a conditioned stimulus and reward delivery, dopamine neurons are not active [153,154]. If dopamine neurons are silent during delays, how can the concentration of dopamine in PFC change to influence working-memory processes seconds after perceiving a stimulus?
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2017, Decision Neuroscience: An Integrative PerspectivePontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning
2016, Cell ReportsCitation Excerpt :The roles of VTA non-DA efferents in appetitive reward learning remain poorly understood. During appetitive Pavlovian learning, midbrain DA neurons exhibit phasic burst firing activity to unconditioned appetitive stimuli (Ljungberg et al., 1991). After being repeatedly paired with unconditioned appetitive stimuli, the neutral stimuli become predictive of reward and are able to elicit DA burst activity (Ljungberg et al., 1991; Mirenowicz and Schultz, 1996; Schultz and Romo, 1990).
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Present address: Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
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Present address: Laboratoire de Neurosciences Fonctionelles, U3, CNRS, Marseille, France.