Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments

doi:10.1016/0006-8993(92)90120-X

Brain Research

Volume 573, Issue 1, 21 February 1992, Pages 119-125

https://doi.org/10.1016/0006-8993(92)90120-X Get rights and content

Abstract

Chronic administration of cocaine (50 mg/kg/day for 7 days, s.c. via an osmotic minipump) produced tolerance to inhibition of [³H]dopamine uptake by cocaine in rat striatum but did not produce cross-tolerance to inhibition of [³H]dopamine uptake by nicotine. Chronic nicotinic treatment (6 mg/kg/day for 7 days, s.c. via an osmotic minipump), however, produced tolerance to the inhibition of [³H]dopamine uptake by nicotine and cross-tolerance to inhibition of uptake by cocaine in rat striatum. Nicotine did not inhibit uptake of [³H]dopamine in the nucleus accumbens of saline-treated animals. In this tissue, both cocaine and nicotine treatments produced tolerance to cocaine, as in striatum. Unlike the effects on [³H]dopamine uptake, chronic cocaine infusion did not have any effect on the ability of cocaine to inhibit [³H]sorotonin uptake in either brain region.

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Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments

Abstract

Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labeling of the dopamine uptake complex

J. Neurochem.

The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action

Eur. J. Pharmacol.

High affinity [3H]GBR 12783 binding to a specific site associated with the neuronal dopamine uptake complex in the central nervous system

Eur. J. Pharmacol.

Dissociation of the apparent relationship between nicotine tolerance and upregulation of nicotinic receptors

Brain Res. Bull.

Simultaneous analysis of families of sigmoidal dose-response curves: application to bioassay, and physiological dose-response curves

Am. J. Physiol.

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis

Life Sci.

Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in rat nucleus accumbens but not in striatum

Brain Research

Nicotine indirectly inhibits [3H]dopamine uptake at concentrations that do not directly inhibit [3H]dopamine release in rat striatum

J. Neurochem.

Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex

Brain Research

Characterization of binding of [3H]GBR 12935 (1-[2-diphenylmethoxyethyl]-4-(3-phenylpropyl)piperazine) to membranes and to solubilized membrane extracts from terminal field regions of mesolimbic, mesocortical and nigrostriatal dopamine pathways

Neuropharmacology

Characterization of sodium-dependent [3H]GBR 12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex

J. Neurochem.

Behavioral and neurochemical effects of acute and daily cocaine administrations in rats

J. Pharmacol. Exp. Ther.

Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens

Synapse

Biochemical and pharmacological characterization of [³H]GBR 12935 binding in vitro to rat striatal membranes: labeling of the dopamine uptake complex

High affinity [³H]GBR 12783 binding to a specific site associated with the neuronal dopamine uptake complex in the central nervous system

Daily cocaine treatment produces a persistent reduction of [³H]dopamine uptake in rat nucleus accumbens but not in striatum

Nicotine indirectly inhibits [³H]dopamine uptake at concentrations that do not directly inhibit [³H]dopamine release in rat striatum

Characterization of binding of [³H]GBR 12935 (1-[2-diphenylmethoxyethyl]-4-(3-phenylpropyl)piperazine) to membranes and to solubilized membrane extracts from terminal field regions of mesolimbic, mesocortical and nigrostriatal dopamine pathways

Characterization of sodium-dependent [³H]GBR 12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex