Research reportProstaglandin E2 protects cultured cortical neurons against receptor-mediated glutamate cytotoxicity
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2018, Journal of Psychiatric ResearchCitation Excerpt :However, PGE2, one of pro-inflammatory mediators, was showed to be elevated in the plasma or platelets of SCZ patients (Das and Khan, 1998; Garcia-Alvarez et al., 2017; Martinez-Gras et al., 2011) due to increased COX-2 expression and activity (Das and Khan, 1998). Since PGE2 exhibits opposite effects as a neurotoxican (Kawano et al., 2006) and a neuroprotectant (Akaike et al., 1994) when activating different receptors, the changes of PG pathway (including PGE2) induced by schizophrenia needs to be further studied. TXA2 signaling could modulate vasoconstriction and platelet aggregation, as well as neurotransmission altered in schizophrenia via the stimulation of TX receptors (Mitsumori et al., 2011; Ross, 2003), such as dopaminergic and serotonergic systems (Di Pietro and Seamans, 2007), and glutamatergic and γ-aminobutyric acid (GABA) signal transduction (Mitsumori et al., 2011).
Prostaglandin E<inf>2</inf> induces apoptosis in cultured rat microglia
2014, Brain ResearchRapid and simultaneous quantitation of prostanoids by UPLC-MS/MS in rat brain
2014, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesInflammation and the two-hit hypothesis of schizophrenia
2014, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Prostaglandin signaling is regulated by complex mechanisms: members of the signaling family can have synergistic or antagonistic responses to the same signal, depending on temporal and cellular context, creating both pro- and anti-inflammatory responses (for review, see Hata and Breyer, 2004; Ricciotti and FitzGerald, 2011). Additionally, they affect glutamate stimulation, neuroprotection, and cell death (Akaike et al., 1994; Cazevieille et al., 1994; Hata and Breyer, 2004; McCullough et al., 2004; Ahmad et al., 2005; Carlson et al., 2009). While there is much more yet to be understood, it is clear that prostaglandin dysregulation interacts with inflammatory components of the immune system and contributes to membrane composition abnormalities in schizophrenia.
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