Elsevier

Contraception

Volume 37, Issue 6, June 1988, Pages 607-619
Contraception

Long-term effects of MPA on human progeny: Intellectual development

https://doi.org/10.1016/0010-7824(88)90007-8Get rights and content

Abstract

Tests of verbal and spatial ability were done on 450 boyg and 537 girls in their late teens of whom 73 and 97, respectively, had been exposed in utero to MPA. Exposed boys achieved higher raw scores than controls on verbal and spatial tests but the differences were explained by their more favorable demographic and social characteristics. Exposed girls did not differ from controls.

Although, mothers of exposed boys reported that their offspring talked and walked later than controls, our results support the hypothesis that intrauterine exposure to MPA at contraceptive doses has no long-term effect on intellectual development.

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  • In an in-vitro model using human fetal membranes, 17-α hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening

    2017, American Journal of Obstetrics and Gynecology
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    Studies with primary human chorion cells, in a mouse inflammatory-mediated parturition model, and our previously published data suggest MPA may be more promising than 17OHP-C for the prevention of preterm birth.57,75-78 Clinicians have hesitated in utilizing MPA for the prevention of spontaneous preterm birth because of potential androgenic fetal effects, but published studies have been contradictory, and some long-term studies of first-trimester human fetal exposure have even been reassuring.79-84 However, clinical trials of MPA, all performed decades ago, failed to demonstrate efficacy in preventing spontaneous preterm births in at-risk pregnancies.85-89

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Supported by grant no. 84043 from the World Health Organization and no. 569 from Family Health International.

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